Three different faces of TACI mutations

Çekiç, Şükrü; Çiçek, Fatih; Karalı, Yasin; Görükmez, Orhan; Eren, Erdal; Kılıç, Sara Şebnem

doi:10.1111/sji.12879

Cited by 1 publication

(1 citation statement)

References 12 publications

(13 reference statements)

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“…Notably, the expression of the TNFRSF13B, IFNLR1, TNFRSF12A, and IL12B genes was notably upregulated in BVDV-1-infected PBMCs, which was supported by qRT-PCR validation. TNFRSF13B and TNFRSF12A, which are members of the TNF-like receptor family, regulate immune cell survival and apoptosis and control B-cell antibody responses and immunoglobulin production [52]. Sazzini found that TNFRSF13B might also be associated with innate immunity, expanding beyond adaptive immunity roles [53].…”

Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomics and Proteomics Analysis Reveals Immune Response Process in Bovine Viral Diarrhea Virus-1-Infected Peripheral Blood Mononuclear Cells

Zhang,

Wang

et al. 2023

Veterinary Sciences

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Bovine viral diarrhea virus (BVDV) causes bovine viral diarrhea-mucosal disease, inflicting substantial economic losses upon the global cattle industry. Peripheral blood mononuclear cells (PBMCs) are the central hub for immune responses during host-virus infection and have been recognized as crucial targets for BVDV infection. In order to elucidate the dynamics of host-BVDV-1 interaction, this study harnessed RNA-seq and iTRAQ methods to acquire an extensive dataset of transcriptomics and proteomics data from samples of BVDV-1-infected PBMCs at the 12-h post-infection mark. When compared to mock-infected PBMCs, we identified 344 differentially expressed genes (DEGs: a total of 234 genes with downregulated expression and 110 genes with upregulated expression) and 446 differentially expressed proteins (DEPs: a total of 224 proteins with downregulated expression and 222 proteins with upregulated expression). Selected DEGs and DEPs were validated through quantitative reverse transcriptase-polymerase chain reaction and parallel reaction monitoring. Gene ontology annotation and KEGG enrichment analysis underscored the significant enrichment of DEGs and DEPs in various immunity-related signaling pathways, including antigen processing and presentation, complement and coagulation cascades, cytokine-cytokine receptor interaction, and the NOD-like receptor signaling pathway, among others. Further analysis unveiled that those DEGs and DEPs with downregulated expression were predominantly associated with pathways such as complement and coagulation cascades, the interleukin-17 signaling pathway, cytokine-cytokine receptor interaction, the PI3K-Akt signaling pathway, the tumor necrosis factor signaling pathway, and the NOD-like receptor signaling pathway. Conversely, upregulated DEGs and DEPs were chiefly linked to metabolic pathways, oxidative phosphorylation, complement and coagulation cascades, and the RIG-I-like receptor signaling pathway. These altered genes and proteins shed light on the intense host-virus conflict within the immune realm. Our transcriptomics and proteomics data constitute a significant foundation for delving further into the interaction mechanism between BVDV and its host.

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Section: Discussionmentioning

confidence: 99%