Three-Component Solvent-Free Synthesis of 3, 4-Dihydropyrimidones and Thiones by Iron-Phosphonate Nanoparticle

Shekh, Asma; Goodajdar, Bijan Mombeni; Asghariganjeh, Mohamad Reza

doi:10.1080/10406638.2021.1948875

Cited by 3 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method offers a few advantages, including a reusable catalyst, easy setup, and rapid reaction rates. [ 137 ]…”

Section: Application Of Nanocatalyst In Biginelli Reactionmentioning

confidence: 99%

“…No [136] 10. Aromatic aldehydes, ethyl acetoacetate, and urea/thiourea Fe-NMPA Solvent-free conditions 92-96 [137] 11.…”

Section: Smentioning

confidence: 99%

“…This method offers a few advantages, including a reusable catalyst, easy setup, and rapid reaction rates. [137] Tahmasbi and researchers in 2022 have accomplished the production of DHPMs using a solid acid nanocatalyst (nano-γ-Fe 2 O 3 -SO 3 H). The intrinsic activity of nanoγ-Fe 2 O 3 -SO 3 H catalyst was examined through a suitable and environmentally sustainable analysis, to produce a one-pot synthesis of DHPMs using the Biginelli reaction.…”

Section: Acidic-supported Mnp-supported Catalystsmentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

Shakya

Kurmi

Patel

2023

Applied Organom Chemis

View full text Add to dashboard Cite

The discovery of a new class of heterocyclic compounds by Pietro Biginelli in 1891 was regarded as a watershed point in the history of chemistry. Biginelli is a well‐known organic chemistry technique for generating dihydropyrimidones/thiones, which are important biological compounds. The chemistry of the Biginelli motifs has been studied in drug development because of the extensive use of multiple Biginelli adducts in various domains. The current review focuses on the magnetic reusable iron nanocatalysts, imparting their catalytic role in the Biginelli reaction, which can be impregnated with ionic liquids, Lewis's acids, metal (monometallic or bimetallic), or hybrid polymers as catalyst support. Our ongoing interest in developing environmentally friendly synthetic methodologies prompted us to investigate the utility of magnetically reusable catalysts where workup provides an eco‐friendly approach in comparison with traditional methods to provide a clear understanding of pathways leading to the formation of Biginelli adducts.

show abstract

“…This method offers a few advantages, including a reusable catalyst, easy setup, and rapid reaction rates. [ 137 ]…”

Section: Application Of Nanocatalyst In Biginelli Reactionmentioning

confidence: 99%

“…No [136] 10. Aromatic aldehydes, ethyl acetoacetate, and urea/thiourea Fe-NMPA Solvent-free conditions 92-96 [137] 11.…”

Section: Smentioning

confidence: 99%

Section: Acidic-supported Mnp-supported Catalystsmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

Shakya

Kurmi

Patel

2023

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Recent advances in the synthesis of dihydropyrimidinones via biginelli reaction

Mushtaq,

Munawar,

Parveen

et al. 2024

J IRAN CHEM SOC

View full text Add to dashboard Cite

Catalyst-free Approach to Dihydropyrimidones Using Glycerol/Ethyl Lactate as a Recyclable and Biodegradable Promoting Medium

Kushwaha,

Singh,

Baranwal

et al. 2024

LOC

View full text Add to dashboard Cite

Abstract:: A variety of dihydropyrimidone compounds were synthesised using an effective one-pot, multicomponent, environmentally friendly reaction of aromatic aldehydes, urea/thiourea, ethyl acetoacetate, and glycerol/ethyl lactate. To the best of our knowledge, this is the first catalyst-free strategy for the synthesis of this key scaffold with medicinal chemistry applications. Other significant aspects of the current approach consist of the employment of glycerol/ethyl lactate as a biodegradable and environmentally friendly reaction medium-cum-promoter, the use of easily available substrates, moderate reaction conditions, ease of use, a wide substrate scope, a short reaction time, easy workup, and excellent yields, and atom efficiency, which make the disclosed procedure an excellent alternative to existing methods.

show abstract

Three-Component Solvent-Free Synthesis of 3, 4-Dihydropyrimidones and Thiones by Iron-Phosphonate Nanoparticle

Cited by 3 publications

References 44 publications

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

Recent advances in the synthesis of dihydropyrimidinones via biginelli reaction

Catalyst-free Approach to Dihydropyrimidones Using Glycerol/Ethyl Lactate as a Recyclable and Biodegradable Promoting Medium

Contact Info

Product

Resources

About