Three-component solvent-free diastereoselective formation of oxo-thiazolidinylthiazoles under microwave irradiation

Abstract

The one-pot diastereoselective cyclisation of 4,4′-bis(2″-aminothiazol-4″-yl)bibenzyl to 4,4′-bis[2″-(2″′-aryl-5″′-methyl/carboxymethyl-4″′-thiazolidinon-3″′-yl)thiazol-4″-yl]bibenzyls, in high yields (85-96%) under the influence of microwave radiation, is described.

Novel one-pot Facile Synthesis of Thiopyranopyrazole Using [H mim]HSO4 Catalyst

“…Pollution free synthesis of organic compounds in presence of either non toxic solvents or in absence of solvent is an important challenge. [1][2][3] One-pot sequential multi-step reactions are of increasing academic, economical and ecological interest because they address fundamental principles of synthetic efficiency and reaction design, so called multicomponent reactions (MCRs). It has an outstanding status in modern organic synthesis and medicinal chemistry because they are one-pot processes bringing together two or more than two components and exhibit high atom economy and high selectivity.…”

[bmim]OH promoted hydroalkynylation of nitrile and intramolecular hydroamination of the carbon–carbon multiple bond: an efficient and eco-compatible strategy for the synthesis of indolizinones

“…ILs are reported to have displayed significant roles as catalysts, reaction media and reagents and are easy to recover and reuse. [13][14][15] Buoyed from the above facts and to circumvent the abovementioned drawbacks, as well as a part of our ongoing endeavour for the construction of simple, efficient, versatile synthetic methodologies for biodynamic heterocyclic scaffolds, [16][17][18][19][20][21][22] we have developed an eco-compatible, facile and atom economical methodology using 2-cyanopyridine and phenylacetylene as reactants, [bmim]OH as an alternative reaction medium and promoter, and microwave activation as an alternative energy source to furnish indolizinones in 72-98% yield (Scheme 1).…”

A novel anthranilic acid based multi-component strategy for expeditious synthesis of 4(3H)-quinazolinone N-nucleosides

“…[12][13][14][15] The objective of the present work is to enhance drug-discovery in the form of the development of a general green synthesis of 2-substituted-4(3H)-quinazolinone N-nucleosides, a novel potent HIV-1 reverse transcriptase inhibitor scaffold from readily available materials. Prompted by the above mentioned reports and in pursuing our work on new solvent-free cyclization procedures, [16][17][18][19][20] we devised an original and novel montmorillonite K-10 claycatalysed MW-activated synthesis of 2-aryl-3-(β-D-ribofuranosyl)-3H-quinazolin-4-ones 5 from a substituted/ unsubstituted anthranilic acid 3, ribosylamine 2 and a substituted/ unsubstituted benzoic acid 4 in a one-pot reaction.(Scheme1). Montmorillonite K-10 clay MW, 6-10 min.…”