Three‐Component Reactions of Quinoxalin‐2(1H)‐ones: Recent Advances

Abstract

The multicomponent reactions of quinoxalin‐2(1H)‐ones has attracted considerable interest due to their significant biological and chemical activities. The very recent advances (from 2021 to the beginning of 2023) on the radical three‐component cascade reaction of quinoxalin‐2(1H)‐one derivatives at the C3 position were summarized in this mini‐review. According to the kind of radical types involved, some representative examples and detailed reaction mechanism have been categorized and discussed.The red front was covered by Figure 1.

Recyclable V2O5/g-C3N4 Heterojunction-Catalyzed Visible-Light-Promoted C3–H Trifluoromethylation of Quinoxalin-2-(1H)-ones

“…The trifluoromethyl (CF 3 ) group has attracted widespread attention in pharmaceuticals and drug candidates given its special chemical properties that can dramatically alter the bioavailability, lipophilicity, and metabolic activity . Quinoxalin-2-(1 H )-ones are widely recognized as privileged nitrogen-containing scaffolds given their significant biological and pharmaceutical properties in drug discovery . In particular, 3-trifluoromethylated quinoxalinones have attracted long-lasting interest due to their unique physiochemical and interesting pharmacological activities .…”

Photoinduced Dehydrogenative Amination of Quinoxalin-2(1H)-ones with Air as an Oxidant

“…More notably, 3-functionalized quinoxalinones exhibit remarkable pharmacological and biological characteristics. Several efficient methods that focus on C3–H selective functionalization have been utilized for the creation of varied 3-functionalized quinoxalinones like arylation, acylation, alkoxylation, amination, alkylation, phosphonation, sulfenylation, and trifluoromethylation reactions. Among the diverse functionalized quinoxalinones, 3-aminoquinoxalin-1­(1 H )-ones have gained attention due to their therapeutic applications.…”

Photocatalyzed Acylation of Azauracil Derivatives with Aldehydes

“…In recent years, the functionalization of N-heterocycles has become a crucial focus in modern drug discovery and development endeavors . By utilizing methods to functionalize N-heterocycles, researchers can greatly expand the structural variety of these compounds, leading to the discovery of novel bioactive molecules through innovative synthetic routes . The emerging field of photocatalysis has revolutionized the efficient formation of chemical bonds using clean solar energy .…”