Three‐Component Acylation/Peroxidation of Alkenes through Visible‐Light Photocatalysis

Abstract

A three‐component acylation/peroxidation of alkenes through visible‐light photocatalysis was described. The acyl radical was generated by a hydrogen atom transfer process and enabled the radical addition and peroxidation. Various indole‐3‐carbaldehyde and styrene derivatives were subjected to the current visible light photochemical conditions, delivering β‐peroxy‐ketones in moderate to good isolated yields.

Recent advances in three-component radical acylative difunctionalization of unsaturated carbon–carbon bonds

“…Indole-3-carbaldehyde was employed in Zhu's system, leading to diversified β-peroxy-indole-ketones (Scheme 5E). 27 TBHP could produce tBuO • via homolysis of O-O bonds under thermal conditions. The Li group 28 and Lu group 29 developed a catalytic amount of base-promoted epoxy acylation of olefins (Scheme 5F and G).…”