Three Cases of Recurrent Malignant Astrocytoma and Review of Clinical Experience

Mh, Seegenschmiedt; Ul, Karlsson; Black, Perry; Lw, Brady

doi:10.1097/00000421-199512000-00011

Cited by 7 publications

(8 citation statements)

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“…Further studies in a tumour model (mammary adenocarcinomas implanted in thighs of C3H mice) verified that a 1.0 GHz system could be employed in a living animal model to provide localised hyperthermia in deep-seated tumours [2]. In humans, interstitial MW hyperthermia was found to effectively heat tumours, provide local control and significantly boost the effectiveness of both radiation therapy and chemotherapy in randomised trials [14,[25][26][27][28][29][30][31][32]. It is important to note that no improvement in response was observed if the hyperthermia temperature goal of 42.5 C for 45-60 min was not reached [33].…”

Section: Background On Mw Heatingmentioning

confidence: 92%

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan¹,

Brace

2016

International Journal of Hyperthermia

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The use of microwaves (MW) for thermal cancer treatment began in the late 1970s. At first, hyperthermia was induced by using single antennas applied interstitially. This was followed by arrays of multiple interstitial antennas driven synchronously at 915 or 2450 MHz. This early work focused on hyperthermia as an adjuvant therapy, but more recently has evolved into a thermally ablative monotherapy. Increased power required to thermally ablate tissues required additional developments such as internally cooled antennas. Larger tumours have also been ablated with MW antenna arrays activated synchronously or non-synchronously. Numerical modelling has provided clinical treatment planning guidance and device design insight throughout this history. MW thermal therapy systems, treatment planning, navigation and image guidance continue to evolve to provide better tools and options for clinicians and patients in order to provide targeting optimisation with the goal of improved treatment for the patient and durable cancer eradication. This paper reviews the history and related technological developments, including antenna design, of MW heating for both hyperthermia and ablation.

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Section: Background On Mw Heatingmentioning

confidence: 92%

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan¹,

Brace

2016

International Journal of Hyperthermia

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“…These had improved performance in arrays when compared to a helical array. There are other more recent MW antenna designs that have been reported [14,46,[53][54][55][56][57] and a retrospective article is available comparing various designs [58].…”

Section: Mw Antenna Design Evolutionmentioning

confidence: 99%

“…Accordingly, tissue temperatures achieved were between 42 and 50 C [7]. Interstitial hyperthermia for localised cancer was found to effectively heat tumours and provide local control [7][8][9][10][11][12][13][14] and significantly boost the effectiveness of both radiation therapy and chemotherapy in randomised trials [7,15,16]. No difference was seen in radiation with or without heat for complete response if the hyperthermia treatment did not meet its temperature goals of 42.5 C for 45 to 60 min in the entire tumour [17].…”

Section: Introductionmentioning

confidence: 99%

Interstitial microwave transition from hyperthermia to ablation: Historical perspectives and current trends in thermal therapy

Ryan¹,

Turner

Hamilton

2010

International Journal of Hyperthermia

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This work reviews the transition from hyperthermia to ablation for cancer treatment with interstitial microwave (MW) antennas. Early work utilising MW energy for thermal treatment of cancer tissue began in the late 1970s using single antennas applied interstitially or the use of multiple interstitial antennas driven with the same phase and equal power at 915 or 2450 MHz. The original antenna designs utilised monopole or dipole configurations. Early work in thermal therapy in the hyperthermia field eventually led to utilisation of these antennas and methods for MW ablation of tumours. Efforts to boost the radiated MW power levels while decreasing antenna shaft temperatures led to incorporation of internally cooled antennas for ablation. To address larger tumours, MW treatment utilised arrays that were simultaneously activated by either non-synchronous or synchronous phase operation, benefiting both hyperthermia and ablation strategies. Numerical modelling was used to provide treatment planning guidance for hyperthermia treatments and is expected to provide a similar benefit for ablation therapy. Although this is primarily a review paper, some new data are included. These new data show that three antennas with 2.5 cm spacing at 45 W/channel and 10 min resulted in a volume of 89.8 cm(3) when operated synchronously, but only 53.4 cm(3) non-synchronously. Efficiency was 1.1 (synchronous) versus 0.7 (non-synchronous). MW systems, treatment planning, and image guidance continue to evolve to provide better tools and options for clinicians and patients in order to provide better approach and targeting optimisation with the goal of improved treatment for the patient.

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“…Chemotherapy increases the fraction of patients who survive for 18 months but has only minor eects on the median survival. Other treatment options such as interstitial radiotherapy, stereotactic radiosurgery, hyperthermia, or gene therapy have thus far failed to oer signi®cant enhancement of survival times but have yielded better results in selected cases (Bamberg and Hess 1992;Karlsson et al 1992;Seegenschmiedt et al 1995;Shrieve et al 1995;Sobol et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy in the treatment of recurrent glioblastoma multiforme: ifosfamide versus temozolomide

Paulsen¹,

Hoffmann²,

Becker³

et al. 1999

Journal of Cancer Research and Clinical Oncology

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Three Cases of Recurrent Malignant Astrocytoma and Review of Clinical Experience

Cited by 7 publications

References 0 publications

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Interstitial microwave transition from hyperthermia to ablation: Historical perspectives and current trends in thermal therapy

Chemotherapy in the treatment of recurrent glioblastoma multiforme: ifosfamide versus temozolomide

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