Three cases of recalcitrant cutaneous warts treated with quadrivalent human papillomavirus (HPV) vaccine: the HPV type may not determine the outcome

Hayashi, Atsuhiro; Matsumoto, Kazuya; Mitsuishi, Tsuyoshi

doi:10.1111/bjd.18645

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…To evaluate the treatment efficacy, the commonly employed system involved classifying the response as complete if there was a total clearance of lesions and partial if there was more than a 50% reduction in the number of lesions [ 9 , 10 , 11 ]. An illustrative instance is the case series described by Hayashi et al in 2020, wherein the administration of the qHPV vaccine resulted in the complete resolution of multiple warts in two individuals at disparate ends of the age spectrum, namely 70 years old and 9 years old [ 12 ]. This observation was particularly noteworthy because it demonstrated the effectiveness of cross-linked immunity, as evidenced by the patients’ HPV genotyping indicating the presence of HPV 57 and 27, neither directly targeted by the qHPV vaccine [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…An illustrative instance is the case series described by Hayashi et al in 2020, wherein the administration of the qHPV vaccine resulted in the complete resolution of multiple warts in two individuals at disparate ends of the age spectrum, namely 70 years old and 9 years old [ 12 ]. This observation was particularly noteworthy because it demonstrated the effectiveness of cross-linked immunity, as evidenced by the patients’ HPV genotyping indicating the presence of HPV 57 and 27, neither directly targeted by the qHPV vaccine [ 12 ]. Waldman et al demonstrated more modest outcomes when assessing the qHPV vaccine as a therapeutic approach for cutaneous, extragenital warts in a cohort of 16 patients, two of whom were immunosuppressed.…”

Section: Resultsmentioning

confidence: 99%

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Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Șandru,

Radu,

Petca

et al. 2024

Vaccines

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Human papillomavirus (HPV) encompasses a diverse array of viruses, comprising approximately 200 serotypes that affect humans. While the majority of HPV strains are associated with benign skin or mucous membrane growths, a subset is implicated in severe health conditions, such as cervical, anal, vulvar, and vaginal cancers. Despite the established effectiveness of HPV vaccines in preventing cervical and anal carcinomas in particular, their therapeutic potential in addressing cutaneous diseases linked to diverse HPV strains remains an intriguing area of investigation. This narrative review critically examines the existing literature to assess the viability of HPV immunization as a therapeutic intervention for prevalent cutaneous conditions. These include genital and extragenital cutaneous warts, epidermodysplasia verruciformis, and keratinocyte carcinomas. The findings suggest a promising dual role for HPV vaccines in preventing and treating dermatologic conditions while emphasizing future research directions, including the immunization perspective against β-HPVs. Moreover, the presence of conflicting study outcomes underscores the imperative for larger-scale, randomized trials with well-matched control groups to validate the efficacy of HPV immunization in the dermatologic context. This review contributes valuable insights into the evolving landscape of HPV-vaccine applications in the field of dermatology.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Șandru,

Radu,

Petca

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

Therapeutic Role of HPV Vaccination on Benign HPV-induced Epithelial Proliferations in Immunocompetent and Immunocompromised Patients: Case Study and Review of the Literature

Matucci-Cerinic,

Herzum,

Ciccarese

et al. 2024

Open Forum Infectious Diseases

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Human papillomavirus (HPV) vaccination represents a milestone in primary prevention of sexually transmitted infections. However, little is known about its possible effects on already established HPV infections. We report the case of a 9-year-old immunosuppressed girl with refractory warts, successfully treated with the nonavalent-HPV vaccine and review the literature about the therapeutic effects of HPV vaccination on benign HPV-induced epithelial proliferations in immunocompetent and immunosuppressed patients. In the literature, promising results were shown on cutaneous warts after HPV vaccination, especially in children and young adults, also in immunosuppressed patients, whereas controverse results were found on anogenital warts. These findings suggest a critical need for randomized clinical trials to assess the efficacy of HPV vaccination in the treatment of benign HPV-induced epithelial proliferations.

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Three cases of recalcitrant cutaneous warts treated with quadrivalent human papillomavirus (HPV) vaccine: the HPV type may not determine the outcome

Cited by 2 publications

References 7 publications

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Therapeutic Role of HPV Vaccination on Benign HPV-induced Epithelial Proliferations in Immunocompetent and Immunocompromised Patients: Case Study and Review of the Literature

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