Pyogenic granuloma is a benign tumor that involves the skin and mucosa. It often occurs during pregnancy and the most frequent symptoms are nasal bleeding. The author encountered a case of pyogenic granuloma of the nasal cavity which was resected via the midfacial degloving approach. A 31-year-old woman, 2 months after delivery of a baby, presented with spontaneous left-sided epistaxis and swelling of the bridge of the nose that had started 1 month previously. Physical examination demonstrated a white and dark-red mass that filled her left nasal cavity. The histological findings showed pyogenic granuloma. We determined to resect the mass because it remained 2 months after delivery without spontaneous regression. We chose the midfacial degloving approach to gain access to regions of the midface without external incisions. The entire successful resection was possible with this approach, and there has not been any recurrence for 1 year postoperatively. The cosmetic results were excellent and the patient was satisfied. No significant complications were seen. The midfacial degloving technique can be considered as a valuable procedure with low morbidity and excellent cosmetic outcome. It may be a viable procedure for pyogenic granuloma of the nasal cavity.