Three Cases of Previous Smokers with Rheumatoid Arthritis Who Did Not Respond to Tumor Necrosis Factor Inhibitors Were Treated Successfully with an Anti-Interleukin-6 Receptor Antibody

Iwata, Yukiyoshi

doi:10.1155/2015/806725

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Clinical studies have shown that smoking can interact with certain medications affecting their absorption, distribution, metabolism, and/or elimination 54 . For example, it has been suggested that patients with RA who smoke require higher doses of disease modifying antirheumatic drugs (DMARD) as the potency of antirheumatic agents may be reduced 55–57 . However, it remains unclear if these findings are a consequence of indirect or direct chemical interactions with joint tissues and cells.…”

Section: Discussionmentioning

confidence: 99%

“…54 For example, it has been suggested that patients with RA who smoke require higher doses of disease modifying antirheumatic drugs (DMARD) as the potency of antirheumatic agents may be reduced. [55][56][57] However, it remains unclear if these findings are a consequence of indirect or direct chemical interactions with joint tissues and cells. Additionally, CSE has been shown to impair the ability of OA-affected chondrocytes in vitro to respond to hyaluronic acid treatment.…”

Section: Importance Of Studying Cigarette Smoke's Impact On Oa and St...mentioning

confidence: 99%

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Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

DiNicola,

Martinez,

Walker

et al. 2024

Journal Orthopaedic Research

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Established risk factors for osteoarthritis (OA) include obesity, joint injury, age, race, and genetics. However, the relationship between cigarette smoking and OA has yet to be established. In the present study, we have employed the use of cigarette smoke extract (CSE), the water‐soluble vapor phase of cigarette smoke, with porcine cartilage explants to investigate the effects of cigarette smoking on cartilage catabolism at the tissue level. Articular cartilage explants were first exposed to 2.5%, 5%, and 10% CSE to assess its effects on cartilage homeostasis. Following, the effects of CSE on OA‐like inflammation was observed by culturing explants with a combined treatment of IL‐1β and TNF‐α and 10% CSE (CSE + OA). Cartilage explants were assessed for changes in viability, biochemical composition, extracellular matrix (ECM) integrity, and equilibrium mechanical properties (aggregate modulus and hydraulic permeability). CSE alone leads to both a time‐ and dose‐dependent decrease in chondrocyte viability but does not significantly affect sGAG content, percent sGAG loss, or the ECM integrity of cartilage explants. When IL‐1β and TNF‐α were combined with 10% CSE, this led to a synergistic effect with more significant losses in viability, significantly more sGAG loss, and significantly higher production of ROS than OA‐like inflammation only. Cartilage explant equilibrium mechanical properties were unaffected. Within the timeframe of this study, CSE alone does not cause OA but when combined with OA‐like inflammation leads to worsened articular cartilage degeneration as measured by chondrocyte viability, sGAG loss, proteoglycan staining, and ROS production.

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Section: Discussionmentioning

confidence: 99%

Section: Importance Of Studying Cigarette Smoke's Impact On Oa and St...mentioning

confidence: 99%

Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

DiNicola,

Martinez,

Walker

et al. 2024

Journal Orthopaedic Research

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Impact of secondhand smoking on disease activity in women with rheumatoid arthritis

Hammam

Gheita

2017

Clin Rheumatol

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Smoking is an established risk factor for the development and severity of rheumatoid arthritis (RA) with prominent production of cytokines. The aim of the work was to study the possible effect of secondhand exposure on disease activity in non-smoking female RA patients. This cross-sectional study include 100 women with RA attending the rheumatology outpatient clinic and were grouped according to the non-smoking status into those not exposed to smoking and those considered secondhand smokers (SHS). Disease activity score in 28 joints (DAS28) was calculated and the patients' global assessment (PGA) score were assessed. The mean age of the patients was 45.2 ± 12.1 years and disease duration was 8.3 ± 6 years. Their DAS28 score was 4.3 ± 0.93 with a PGA score of 1.47 ± 1.36. Forty-seven of the patients were SHS and 53 were non-exposed. The secondhand smokers were significantly younger (41.6 ± 11.7 years) than the non-smokers (48.3 ± 11.6 years) (p = 0.005), and the DAS28 was significantly higher (4.6 ± 0.84 versus 4.1 ± 0.97; p = 0.02) compared to non-smokers. The disease duration and medications received were comparable. There is evidence pointing to the important role of secondhand smoking on disease activity in RA female patients. Studying the effect of secondhand smoking in view of the cytokine milieu could help confirm the relation to the disease pathogenesis. Taking into consideration the risk of cardiovascular disease and interplay with other potential factors should be well thought of. It is essential to draw patients' attention to the expected hazardous effect of passive smoking.

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Evaluation of biological‒disease‒modifying antirheumatic drugs in a refractory rheumatoid arthritis patient who was on hemodialysis

Ono¹,

Tomoaki²,

Fukumitsu

et al. 2021

Nihon Toseki Igakkai Zasshi

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Three Cases of Previous Smokers with Rheumatoid Arthritis Who Did Not Respond to Tumor Necrosis Factor Inhibitors Were Treated Successfully with an Anti-Interleukin-6 Receptor Antibody

Cited by 3 publications

References 28 publications

Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

Impact of secondhand smoking on disease activity in women with rheumatoid arthritis

Evaluation of biological‒disease‒modifying antirheumatic drugs in a refractory rheumatoid arthritis patient who was on hemodialysis

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