Three Cases of Postlactational Breast Tumour of a Peculiar Type

Hogeman, K E; Ostberg, G

doi:10.1111/j.1699-0463.1968.tb00489.x

Cited by 27 publications

(8 citation statements)

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“…Breast hamartomas are composed of a random mix of glandular epithelial, fibrous, and fatty tissue. Hogeman and Osbterg were the first to describe the lesion back in 1968 [1] , while the actual term “hamartoma” was created in 1971 by Arrigoni et al In 1994, a case series done by Charpin et al concluded that breast hamartomas account for approximately 4.8% of all benign breast lesions [2] . The exact pathogenesis for breast hamartoma development remains a mystery.…”

Section: Discussionmentioning

confidence: 99%

Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity

Amir

Sheikh

2016

International Journal of Surgery Case Reports

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HighlightsMammary hamartoma is a rare benign lesion accounting for approximately 4.8% of all benign breast masses.There are several variants depending on the composition of glandular and fibroadipose elements including adenolipoma, fibroadenolipoma, and myoid hamartoma.Histologically the lesions show a haphazard admixture of benign mammary glandular tissue, fat, and fibrous strands present in varying proportions.Breast hamartomas are rarely associated with malignancies.Excision of hamartoma is considered curative; though recurrence is seen in 8% of cases.

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Section: Discussionmentioning

confidence: 99%

Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity

Amir

Sheikh

2016

International Journal of Surgery Case Reports

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“…HMGA2 rearrangements are seen in many mesenchymal tumours, 45 and are not specific of breast hamartomas. Cases arising during pregnancy and hormonal receptor expression by the stromal component may suggest a hormonal influence 2,13,16,35 …”

Section: Discussionmentioning

confidence: 99%

“…A hamartoma is a benign tumour made of a mixture of components normally found in the organ where it develops. 1 Breast hamartomas were first described by Hogeman and Ostberg in 1968, 2 and the term was first used by Arrigoni et al in 1971. 3 In the latest version of the World Health Organisation (WHO) classification of breast tumours they are included in the same chapter as fibroadenomas and phyllodes tumours, as they bear some resemblance with them.…”

Section: Introductionmentioning

confidence: 99%

Breast hamartoma: reassessment of an under‐recognised breast lesion

Alran

Chamming’s²,

Auriol-Leizagoyen³

et al. 2021

Histopathology

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Breast hamartoma: reassessment of an under-recognised breast lesionAims: Breast hamartomas are an under-recognised lesion because they lack a distinctive microscopic appearance. Microscopic diagnosis can often conclude 'no significant lesion' or 'normal breast tissue', leading to repeated biopsies and diagnostic delay. We describe the histological, immunohistochemical and radiological features of breast hamartomas with the aim of identifying specific signs to facilitate their diagnosis and to differentiate them from normal breast and fibroepithelial lesions. Methods and results: Forty-seven breast hamartomas were reassessed (histological diagnosis and imaging features). An immunohistochemical study [oestrogen receptor (ER), progesterone receptor (PR), CD34, high-mobility group A2 (HMGA2)] was performed. On breast imaging, hamartomas most often presented as probably benign solid masses with circumscribed margins and variable densities. Histologically, breast hamartomas resembled normal breast, although their stromal component was predominant, separating randomly scattered epithelial elements with areas of pure collagenous stroma. Pseudoangiomatous stromal hyperplasia (PASH) was present in 93.6% of cases and CD34 antibody highlighted intralobular, perilobular and interlobular distribution of CD34-positive fibroblasts. By comparison, CD34 was mainly expressed in the intralobular normal breast tissue stroma. Hamartoma stromal cells expressed HMGA2, ER and PR in 79%, 66% and 76.3% of our cases, respectively, compared to 7.7%, 23% and 19% in normal breast tissue, respectively (P < 0.0001; P = 0.0005; P < 0.0001). Conclusions: After ascertaining that core needle biopsy is effectively intralesional, breast hamartomas can be diagnosed with confidence by taking into account the presence of stromal changes, PASH, interlobular distribution of CD34-positive fibroblasts, HMGA2 and hormonal receptor stromal expression.

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“…The first description of mammary hamartoma had been written by Hogeman and Ostberg in their report in 1968 (7). Mammary hamartoma is circumscribed lesion composed of disorganized overgrowth of normal breast tissues, and showing various composition of ductal and lobular epithelium and stromal elements.…”

Section: Discussionmentioning

confidence: 99%

Ductal carcinoma in situ of the breast arising in encapsulated mammary hamartoma ; A case report

Komaki¹,

Funagayama

Tomokazu

et al. 2020

J. Med. Invest.

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Mammary hamartoma is benign lesion and relatively rare. 17 cases of breast cancer associated with a hamartoma had been previously documented in the literature. We describe herein a case of noninvasive ductal carcinoma of the breast arising in hamartoma in a woman of 60's. The discordance of images of the mass between mammogram and ultrasonogram can lead us to detect the carcinoma within the hamartoma in our case.

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Three Cases of Postlactational Breast Tumour of a Peculiar Type

Cited by 27 publications

References 1 publication

Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity

Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity

Breast hamartoma: reassessment of an under‐recognised breast lesion

Ductal carcinoma in situ of the breast arising in encapsulated mammary hamartoma ; A case report

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