Three cases of near-tetraploid acute myeloid leukemias originating in pluripotent myeloid progenitors

Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases

“…4 Near-tetraploid blast cells are characterized by their large size on bone marrow smears, [2][3][4] but individual chromosomal abnormalities are often difficult to analyze because of their 'fuzzy appearance'. 1,4 In order to collect more information on these rarely occurring AML, immunophenotypic and clinical databases of members of the EGIL group were searched to identify morphologically and immunophenotypically well-defined NT-AML patients. As this study was not initiated from comprehensive cytogenetic databases, the results do not provide any indication on the incidence of NT-AML.…”

“…However, it allowed to retrospectively retrieve information on 25 cases of NT-AML, diagnosed between 1989 and 2003 in eight European countries. 4,5 This group of NT-AML comprised nine females and 16 males with a median age of 64 years (range 19-81 years) ( Table 1). Seventeen patients presented with de novo NT-AML but two of them (no.…”

Rare coincidence of hypertriploid chromosome number and aberrant coexpression of the lymphoid-associated antigen CD5 in acute myeloid Leukaemia FAB M0

“…All patients reported in these series have a short overall survival, and two died soon after a low-dose chemotherapy. 8 Yeh et al 9 reported on a 43-year-old woman with AML M0 and a near-tetraploid chromosome number. Like the other patients, is woman died in neutropaenic phase after the induction therapy.…”

A more precise diagnosis of AML M0, a part of which exhibits a near-tetraploid karyotype

“…Both patients died of pancytopenia after induction treatments on the 24th and 52nd day of therapy, respectively. Recently we have shown 3 that at least six of 17 patients with near-tetraploid AML were classified as AML M0, often with erythroid and/or megakaryocytic dysplasia pointing to their origin in myeloid pluripotent progenitors. Near-tetraploid karyotype is easily morphologically recognized by the large blast size.…”

“…Near-tetraploid karyotype is easily morphologically recognized by the large blast size. 2,3 Thus, AML M0 in a proportion of cases may be a subtype of near-tetraploid AML and in a further proportion a subtype of AML with a complex karyotype in the morphologic, immunologic, and cytogenetic (MIC) classification.…”