Three cases of Lipschütz vulval ulceration

Alés-Fernández, Martina; Rodríguez‐Pichardo, A.; García-Bravo, Begoñá; Ferrandiz‐Pulido, L.; Camacho-Martínez, FM

doi:10.1258/ijsa.2010.010044

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The age of the patients was either in the second or third decade except in cases reported in the Archel et al 6 study (17 months), the Alés-Fernández et al 7 study (2 months), and in the Vieira-Baptista et al 8 study (79 years). None of the patients had provided their sexual history prior to the onset of genital ulcers except for the patients in the studies by Chanal et al, 9 Martín et al, 10 Brinca et al, 11 and Halvorsen et al 12 No patient history suggestive of trauma or child sexual abuse was identified.…”

Section: Resultsmentioning

confidence: 99%

Lipschütz Ulcers: A Literature Review Based on 79 Cases

Govindan

2016

EMJ Repro Health

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Lipschütz ulcers (LU) are acute genital ulcers that occur in women. These ulcers are painful and cause enormous emotional stress to the affected person. It is also of the utmost important for the treating physician to differentiate LU from sexually transmitted ulcers like syphilis, herpes genitalis, and chancroid. The aetiology of LU is not known but recent studies have proposed that it is associated with viral infections, such as the Epstein–Barr virus (EBV) and the cytomegalovirus (CMV), as well as other bacterial infections, such as mycoplasma. Using the PubMed database, articles published between the years of 2003 and 2015 were collected. A total of 20 studies (N=79) fulfilled the inclusion criteria and were selected for analysis. All the published articles were reviewed and relevant data extracted. The age range of patients included in these studies was 17 months to 79 years old. The causative organism was unknown in 50 patients (63%), EBV in 13 patients (16%), Mycoplasma pneumoniae in 4 patients (5%), CMV infections in 4 patients (5%), Mycoplasma fermentans in 3 patients (3.7%), mumps in 1 patient (1.2%), paratyphoid fever in 1 patient (1.2%), parvovirus B19 in 1 patient (1.2%), co-infection of influenza B and adenovirus in 1 patient (1.2%), and co-infection of EBV and CMV in 1 patient (1.2%). Even though viral and bacterial infections had been linked with LU in many of the patients included in these studies, the aetiology remains unknown. Hence, more research is warranted to ascertain the aetiological factors of LU.

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Section: Resultsmentioning

confidence: 99%

Lipschütz Ulcers: A Literature Review Based on 79 Cases

Govindan

2016

EMJ Repro Health

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“…Based on retrospective hospital‐based studies of women with acute genital ulcers, it is reported to vary at 4–35%, depending on the diagnostic criteria used, given that no consensus actually exists for the disease diagnosis. Most of the subsequent reports focus on the first type of ulcer described by Lipschütz displaying deep ulceration with excruciating pain of acute febrile onset, which rarely recurs . Only a few reports described the afebrile, painless and recurrent nature of the second type of ulcer which was clearly pointed out by Lipschütz .…”

Section: Brief Review Of Literaturementioning

confidence: 99%

“…Most of the subsequent reports focus on the first type of ulcer described by Lipsch€ utz displaying deep ulceration with excruciating pain of acute febrile onset, which rarely recurs. [6][7][8][9] Only a few reports described the afebrile, painless and recurrent nature of the second type of ulcer which was clearly pointed out by Lipsch€ utz. 10,11 Some retrospective studies no longer distinguished between the two kinds of ulcers mentioned by Lipsch€ utz.…”

Section: Brief Review Of Literaturementioning

confidence: 99%

“…After the first description of ulcus acutum vulvae by Lipschütz, the disease is also named as Lipschütz disease, non‐sexually related acute genital ulcers, Lipschütz genital or vulvar ulceration, Lipschütz ulcer and EBV vulvar ulceration, among others. As infectious origin is confirmed in only 30% of the reported cases, the disease remains a diagnosis by exclusion (diagnosis per exclusionem).…”

Section: Nomenclature and Diagnosismentioning

confidence: 99%

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Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Chen

Plewig

2019

Acad Dermatol Venereol

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Since its first description as ulcus vulvae acutum by Benjamin Lipschütz in 1912, the etiopathogenesis of this peculiar genital ulcer remains incompletely understood. In his original description, two different types of genital ulcers were observed and proposed, which were not precisely defined and distinguished in most subsequent reports. The first type is characterized by acute excruciating genital ulcers of first‐time onset with self‐limited non‐recurrent course in association with gravely symptomatic systemic infections, in which a primary Epstein–Barr virus (EBV) infection is later identified to be probably the most common aetiology. The second type of ulcer usually refers to little painful ulcers of unknown etiopathogenesis in the absence of fever or chills and with a slow torpid progression and recurrent nature. Differentiation from idiopathic aphthous ulcers is unclear. The changes of the cervicovaginal microbiota and microbiome in diseased state deserve further clarification. Acute genital ulcers associated with primary EBV infection in women have drawn attention since 1970s, while the corresponding penile ulcers in men were already known in 1950s. First presented in 1973, juvenile gangrenous vasculitis of the scrotum with an acute painful scrotal ulcer preceded by symptomatic pharyngeal infections can be considered as the male counterpart of ulcus vulvae acutum, and the future clinical survey should include primary EBV infection.

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Lipschütz’s acute vulvar ulcer: a systematic review

et al. 2020

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In previously healthy subjects, vulvar ulcers are mostly caused by sexually transmitted microorganisms. Lipschütz's acute vulvar ulceration, first reported in 1912, is a non-sexually acquired condition characterized by sudden onset of a few genital ulcers. We systematically review presentation, underlying causes and disease duration of Lipschütz's ulceration.Comprehensive source of Excerpta Medica, National Library of Medicine and Web of Science databases was performed. Reports including cases of apparently previously healthy females affected by Lipschütz's ulceration were selected a predefined database was used to extract data on demographics, history, clinical and microbiological findings, and treatment.The search disclosed 158 cases. Almost 90% of cases were ≤20 years of age and sexually inactive. Lesions were usually one to about three, painful, ≥10 mm large, well-delimited, with a fibrinous and necrotic center and a symmetric distribution. Voiding disorders and enlarged inguinal lymph nodes were observed in a large subset of cases. Canker sores were noted in 10% of patients. Lipschütz's vulvar ulceration occurred concomitantly with an infectious disease in 139 cases. Infectious mononucleosis syndrome (N=40) was the most frequently detected well-defined infection, followed by mycoplasma species infections (N=11). The disease resolved after ≤3 weeks. CONCLUSIONS: Lipschütz's ulceration mainly affects both sexually inactive and, less frequently, sexually active subjects ≤20 years of age, presents with ≤3 vulvar ulcers, resolves without recurrences within 3 weeks and is temporarily associated with an infection, most frequently a flu-like illness or an infectious mononucleosis syndrome.

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Three cases of Lipschütz vulval ulceration

Cited by 4 publications

References 5 publications

Lipschütz Ulcers: A Literature Review Based on 79 Cases

Lipschütz Ulcers: A Literature Review Based on 79 Cases

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Lipschütz’s acute vulvar ulcer: a systematic review

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