Three Cases of Lichen Nitidus Associated with Various Cutaneous Diseases

Abstract

Lichen nitidus (LN) is an uncommon, usually asymptomatic cutaneous eruption characterized by the presence of multiple, small, flesh-colored papules. The epidemiologic and pathophysiologic characteristics of LN have not yet been defined. Furthermore, LN has rarely been described in association with other cutaneous diseases. We herein report 3 cases of LN associated with various cutaneous diseases, including lichen striatus, oral lichen planus, and psoriasis vulgaris.

Pediatric lichen nitidus: A single‐center experience

“…LN has been associated with other skin diseases, including lichen planus, lichen spinulosus, atopic dermatitis, lichen striatus, psoriasis, segmental vitiligo, and erythema nodosum . LN has been previously considered by some to be a clinical variant of lichen planus because both dermatoses are very similar clinically and some patients have both skin diseases . Although LN and lichen planus have similar ultrastructural findings, immunofluorescent studies suggest certain differences .…”

“…Generalized LN was specified in 41% of patients, which is a higher than expected incidence. 1,5,13,14 This difference might be due to the inclusion of biopsy-proven cases since arguably, skin biopsy 2,17,18 Although LN and lichen planus have similar ultrastructural findings, immunofluorescent studies suggest certain differences. 16 As noted previously, seven of 17 had comorbid skin conditions.…”

“…Reported disease associations have included Down syndrome, Russell‐Silver syndrome, Niemann‐Pick disease, and neurofibromatosis type 1, though no evidence for any causal link has been shown . Often LN is relatively asymptomatic; however, some cases have itch, at times severe . The present study aims to describe biopsy‐proven LN in a tertiary health center over a 10‐year period.…”

“…Initially described by Pinkus in 1907, lichen nitidus (LN) is a dermatologic condition which presents with multiple shiny, skin‐colored, pinhead‐sized, dome‐shaped papules, generally localized in the genital area, upper limbs, and trunk, rarely involving the palms, soles, or fingernails. Skin lesions may disappear at one region and then appear at another region.…”

“…9,11 Often LN is relatively asymptomatic; however, some cases have itch, at times severe. [1][2][3] The present study aims to describe biopsy-proven LN in a tertiary health center over a 10-year period. Table 1 shows the demographic and clinical characteristics of the pediatric patients who were diagnosed with LN histopathologically.…”