Three Cases of Homozygous <i>β</i><i>δ</i>-Thalassaemia (or Microcythaemia) with High Haemoglobin F in a Sicilian Family

Hematological and Hemoglobin Synthesis Studies in a Family with Hδβ -Thalassemia Trait

“…The imbalanced globin chain production, when studied, is less important than in /5-thalassemia [14]. In this family, hemato logical and clinical findings, as well as defective synthesis of non-a-chains, are more severe than in the previous described cases [4,14,22,24,27] and clearly differ ent from heterozygous HPFH [10,17,19,25,28].…”

“…¿/5-Thalassemia has been mostly encoun tered in Mediterranean [4,24,26,27] and African populations [22], with only a few instances from other racial groups [14]. This report describes a heterozygous form of the disease first suspected in a 9-year-old French girl of Basque Spanish and Italian parentage.…”

Homozygous Delta-Beta-Thalassaemia in a Spanish Woman

“…The first case was described by Brancati and Baglioni [1] in an Italian pa tient. Thereafter, the syndrome was also found in 3 new Italian patients [4], 3 Arabic patients [3] and a Greek patient [5]. Our paper deals with a further case in a Spanish woman, with haematological, biochemical and clinical studies and with a family study of 37 members.…”

Spanish Delta-Beta_-Thalassemia: Hematological Studies and Composition of the Gamma-Chains in Ten Homozygous Patients

“…<5/?-Thalassemia has been reported in patients from different ethnic back grounds, but has mainly been described in persons of Mediterranean origin [1][2][3][4][5][6][7][8][9][10]. The homozygous condition often mani fests itself as a thalassemia intermedia characterized by having only Hb F.…”