Three Cases of Granulomatous Arachnoiditis After Myelography

Ward, W. Timothy; Matheson, M.; Gonski, Alexander

doi:10.5694/j.1326-5377.1976.tb130220.x

Cited by 12 publications

(10 citation statements)

References 4 publications

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“…Recognized risk factors include spinal surgery (an important cause of failed back syndrome in approximately 16% of cases), a variety of myelographic agents, viral and bacterial meningitis, tuberculosis, syphilis, intrathecal haemorrhage, intradural or epidural injections of steroid, antibiotics and anaesthetic agents and lumbar punctures 3 . Oily myelographic media provoke an inflammatory process and become encysted followed by granuloma formation and fibrosis 4 …”

Section: Discussionmentioning

confidence: 99%

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Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: Magnetic resonance features

Shah

Patkar

Parmar

et al. 2001

Australasian Radiology

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The reported incidence of clinically significant arachnoiditis following oil-based contrast media myelography is approximately 1%. The incidence of arachnoiditis in the dorsal spine is even more rare. Acquired arachnoid cyst formation can occur with arachnoiditis of various aetiologies. A case is presented of a patient with chronic backache, radiculopathy, weakness and muscle wasting, who had undergone myelography with oil-based contrast media about 28 years ago. There was no history of spinal surgery, spinal canal stenosis, disc disease or trauma, all of which are known to increase the risk of arachnoiditis. Magnetic resonance imaging features are presented in this case of arachnoiditis with arachnoid cyst formation, and cord tethering.

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Section: Discussionmentioning

confidence: 99%

“…may also contribute to arachnoiditis. Most patients undergoing myelography usually have some of these associations 1,4 . Laitt et al used MRI in 109 patients who had undergone Myodil myelography previously.…”

Section: Discussionmentioning

confidence: 99%

Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: Magnetic resonance features

Shah

Patkar

Parmar

et al. 2001

Australasian Radiology

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“…15 In 1976, Ward et al showed in an autopsy study the general pattern of pathological changes following encystment of the dye, namely, a chronic inflammatory process with fibrosis and granuloma formation. 4 A study by Valentine demonstrated Myodil floating in the ventricular system producing ependymitis. 16 This was also demonstrated in the present case, where CSF sterile cultures confirmed that ependymitis was not bacterial inflammation but was a result of Myodil.…”

Section: Discussionmentioning

confidence: 99%

“…3 Arachnoiditis was reported where contrast media had not been removed. 3,4 Following its introduction, Pantopaque was reported to produce complications ranging from a mild transient systemic reaction to severe, occasionally fatal, meningeal reactions. 5 Iodized oil also was used extensively in Japan in imaging studies of the CNS prior to the 1980s.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous meningitis as a late complication of iodized oil myelography

et al. 2004

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The present report is an autopsy case of an 83 year old man with severe kyphoscoliosis and granulomatous meningitis as a late complication of iodized oil myelography. He suffered from mild cognitive impairment and died of pneumonia. At autopsy, the brain showed yellow-brown granular material on its surface, mainly in the Sylvian fissure. Microscopically, granulation tissue was seen around areas of ossification encasing the foreign material. Iodized oil apparently changed into two types of foreign bodies: eosinophilic membranous lipodystrophy-like features and homogenous yellow crystals of various sizes. The pathology was identical to foreign-body granulomatous meningitis, caused by iodized oil myelography, and caused cognitive impairment in this patient.

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“…There are numerous case reports implicating Pantopaque in the production of arachnoiditis (Erickson, 1979, Greig andWignall, 1966). Cases have been reported even when the material is removed after the myelographic investigation (Ward et al, 1976). In spite of these reports, the relationship between the use of iophendylate and the development of arachnoiditis remains uncertain.…”

Section: Causes Of Arachnoiditismentioning

confidence: 99%

Spinal Arachnoiditis

Esses

Morley

1983

Can. j. neurol. sci.

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SUMMARY:A review of the literature points to the many causes of arachnoiditis and the failure of treatment to arrest or reverse its effects. The true incidence cannot be determined, although it is probably lower than might at first appear from the published articles. In the radiological literature the diagnosis seems to derive from an examination of the films alone, often without reference to the clinical findings or appearance at operation. While attempts at treatment are usually unsuccessful, some iatrogenic cases can be prevented by the avoidance of intrathecal steroid injections or unduly rough or repeated surgical exploration of the lumbar vertebral canal.

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Three Cases of Granulomatous Arachnoiditis After Myelography

Cited by 12 publications

References 4 publications

Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: Magnetic resonance features

Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: Magnetic resonance features

Granulomatous meningitis as a late complication of iodized oil myelography

Spinal Arachnoiditis

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