Three Cases of COVID-19 Disease With Colonic Manifestations

Sattar, Yasar; Connerney, Michael; Rauf, Hiba; Saini, Mannat; Ullah, Waqas; Mamtani, Sahil; Syed, Umer; Luddington, Stephen; Walfish, Aaron

doi:10.14309/ajg.0000000000000692

Cited by 43 publications

(31 citation statements)

References 7 publications

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“…Carvalho et al 16 described a case of SARS-CoV-2 gastrointestinal infection causing acute hemorrhagic colitis with endoscopic findings of coloproctopathy but normal histologic findings. Sattar et al 17 reported three cases of COVID-19 with colonic findings, including colitis and air in the bowel wall.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19

Ibrahim

Karuppasamy

Parambil

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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The COVID-19 pandemic has recently spread worldwide, presenting primarily in the form of pneumonia or other respiratory disease. In addition, gastrointestinal manifestations have increasingly been reported as one of the extrapulmonary features of the virus. We report two cases of SARS-CoV-2 infection complicated by paralytic ileus. The first patient was a 33-year-old man who was hospitalized with severe COVID-19 pneumonia requiring ventilator support and intensive care. He developed large bowel dilatation and perforation of the mid-transverse colon, and underwent laparotomy and colonic resection. Histopathology of the resected bowel specimen showed acute inflammation, necrosis, and hemorrhage, supporting a role for COVID-19-induced micro-thrombosis leading to perforation. The second patient was a 33-year-old man who had severe COVID-19 pneumonia, renal failure, and acute pancreatitis. His hospital course was complicated with paralytic ileus, and he improved with conservative management. Both cases were observed to have elevated liver transaminases, which is consistent with other studies. Several authors have postulated that the angiotensin-converting enzyme 2 receptors, the host receptors for COVID-19, that are present on enterocytes in both the small and large bowel might mediate viral entry and resultant inflammation. This is a potential mechanism of paralytic ileus in cases of severe COVID-19 infection. Recognizing paralytic ileus as a possible complication necessitates timely diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19

Ibrahim

Karuppasamy

Parambil

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…They took the lozenges several times each day, up to doses between 115 to 184 mg Zn/day for 10 to 14 days, and all of these patients recovered. In another case report, three COVID-19 patients 38-74 years of age with additional gut manifestations received zinc sulphate (220 mg Zn daily for 5 days), together with hydroxychloroquine and azithromycine [27]. The latter patients recovered.…”

Section: Zincmentioning

confidence: 99%

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

et al. 2020

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Objectives: The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19. Methods: We conducted an online search for articles published in the period 2010–2020 on zinc, selenium, and vitamin D, and corona and related virus infections. Results: There were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19. Conclusion: We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.

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“…A summary of findings are shown in Table 1. Ten studies of 23 patients (2 of which are pediatric cases) demonstrate thickening of various regions of the small and large bowel wall [17,18,28,[33][34][35][36][37][38][39]. Hyperemia and mesenteric thickening have also been observed in tandem with bowel wall thickening.…”

Section: Abnormal Abdominal Imaging Findingsmentioning

confidence: 99%

“…One case report involved a patient with colonic ileus and air in bowel wall on abdominal CT [35]. Behzad et al similarly reported a patient that showed ileus pattern on abdominal radiograph, along with nonspecific stranding surrounding mildly distended fluid-filled ascending colon [49].…”

Section: Abnormal Abdominal Imaging Findingsmentioning

confidence: 99%

Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review

2020

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Purpose This scoping review evaluated the currently available data related to abdominal imaging in the SARS-CoV-2 infection. Method A systematic review of MEDLINE, EMBASE, SCOPUS, and Web of Science was performed from inception to July 15, 2020 using PRISMA-ScR guidelines. The review included case reports and series discussing radiologic manifestations of SARS-CoV-2 infection in abdominal imaging studies.

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Three Cases of COVID-19 Disease With Colonic Manifestations

Cited by 43 publications

References 7 publications

Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19

Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review

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