Three Cases of Corneal Melting After Instillation of a New Nonsteroidal Anti-Inflammatory Drug

Asai, Tatsuhiko; Nakagami, T; Mochizuki, M.; Hata, Norimasa; Tsuchiya, Takaaki; Hotta, Yoshihiro

doi:10.1097/01.ico.0000177835.93130.d4

Cited by 86 publications

(46 citation statements)

References 10 publications

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“…Subsequent case reports and case series reported severe corneal complications after topical NSAID treatment. [16][17][18][19][20][21][22] A possible concurrent effect of flurbiprofen in our patient cannot be excluded.…”

Section: Discussionmentioning

confidence: 96%

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Rama¹,

Matteo²,

Matuška³

et al. 2009

Journal of Cataract and Refractive Surgery

141

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A 32-year-old man with keratoconus developed corneal melting 5 days after riboflavin/ultraviolet-A corneal collagen crosslinking (CXL). Corneal scraping was positive for Acanthamoeba. The patient was unaware that he was wearing a bandage contact lens and repeatedly rinsed his face and eyelids with tap water. Because of corneal perforation, a large therapeutic keratoplasty à chaud was performed. Although CXL is considered a safe procedure, this case emphasizes the potential risks. We discuss the potential effects of deepithelialization, contact lens placement, instillation of topical nonsteroidal antiinflammatory drugs and anesthetic agents, and the possible role of apoptosis when performing CXL treatment for keratoconus.

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Section: Discussionmentioning

confidence: 96%

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Rama¹,

Matteo²,

Matuška³

et al. 2009

Journal of Cataract and Refractive Surgery

141

View full text Add to dashboard Cite

show abstract

“…[3][4][5][6] Three cases attributed to the use of bromfenac sodium (Xibrom), a newer NSAID, were reported in Japan. 7 We report a case of corneal perforation in a patient with Stevens Johnson syndrome (SJS) following instillation of topical Xibrom on a twice-daily regimen.…”

Section: J Cataract Refract Surg 2007; 33:1644-1646 Q 2007 Ascrs and mentioning

confidence: 99%

Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use

Isawi

Dhaliwal

2007

Journal of Cataract and Refractive Surgery

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We report a case of a 20-year-old woman with tear deficiency secondary to Stevens Johnson syndrome who developed bilateral corneal melting following use of bromfenac (Xibrom), a nonsteroidal antiinflammatory drug (NSAID), for 2 weeks. The patient presented with complaints of light sensitivity and pain in the right eye. The slitlamp examination revealed a corneal perforation with iris plug in the right eye and an 85% thinned cornea in the left eye. She was admitted to the hospital, where Xibrom was discontinued, therapeutic contact lenses were placed, and a regimen of topical antibiotic agents was instituted. One day after admission, penetrating keratoplasty was performed in the right eye, an amniotic membrane was placed in the left eye, and tarsorrhaphy was performed bilaterally. The clinical features of this case highlight the importance of being selective when administering NSAIDs in patients with a compromised ocular surface.

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“…The important factors in these cases were the old age of the patients and the presence of previous ocular surgery or corneal disease, such as bullous keratopathy and bacterial corneal ulcer. Thus, careful observation is required when using bromfenac sodium in the long-term treatment of VKC [31]. …”

Section: Discussionmentioning

confidence: 99%

Topical Bromfenac Sodium for Long-Term Management of Vernal Keratoconjunctivitis

Uchio

Itoh²,

Kadonosono³

2007

Ophthalmologica

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Background/Aims: We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops. Methods: Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period. Results: The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A. Conclusion: These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.

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Three Cases of Corneal Melting After Instillation of a New Nonsteroidal Anti-Inflammatory Drug

Abstract: A new NSAID, bromfenac sodium, can lead to severe corneal melting. These findings, together with similar previous reports concerning diclofenac sodium and ketorolac, suggest that careful observation is required when using topical NSAIDs in the treatment of corneal disease.

Cited by 86 publications

References 10 publications

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use

Topical Bromfenac Sodium for Long-Term Management of Vernal Keratoconjunctivitis

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