Three advantages of using traditional Chinese medicine to prevent and treat tumor

Ling, Changquan; Yue, Xiao-Qiang; Chen, Ling

doi:10.1016/s2095-4964(14)60038-8

Cited by 167 publications

(120 citation statements)

References 26 publications

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“…In addition, to investigate the effect of Huang-Qi injection on shortterm prognosis in childhood with acute lymphoblastic leukemia (ALL), a retrospective analysis was performed circulation and removing blood stasis, and the third with properties of clearing heat and detoxifying (11). Numerous studies have shown that many TCMs (e.g., Ginseng Radix, Radix astragali, Radix Codonopsis, and Poria cocos) with properties of spiriting vital energy play important roles in cancer treatment with the basis summarized as follows: (i) improving immune system function; (ii) protecting hematopoiesis of bone marrow; (iii) harmonizing gastrointestinal function (12,13). In addition, numerous studies have shown that many TCMs with properties of promoting blood circulation and removing blood stasis (e.g., Angelica sinensis Radix, and Curcuma longa), or clearing heat and detoxifying (e.g., Hedyotis diffusa willd, and Scutellaria barbata), also play important roles in cancer treatment involving antiproliferation, anti-inflammation, anti-oxidation, antiangiogenesis, anti-thrombotic, immune-modulation and so on (7,11,12,14).…”

Section: Radix Astragalimentioning

confidence: 99%

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Zhao

Zhou

et al. 2015

BST

365

268

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Section: Radix Astragalimentioning

confidence: 99%

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Zhao

Zhou

et al. 2015

BST

365

268

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“…Franquet (Cucurbitaceae). TBMS1 has been shown to have potent cytotoxicity against several cancer cell lines, including human glioma U87 [13] , HepG2, esophageal squamous cell carcinoma EC109 [14] , ovarian cancer SKOV-3 [15] , CDDP-resistant A2780 [16] , choriocarcinoma JEG-3 [17] , lung cancer A549 [18] , cervical carcinoma HeLa [19] and BGC823 gastric cancer cells [20] . However, its effect on human prostate cancer remains unexplored.…”

Section: Original Articlementioning

confidence: 99%

Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro

Yang

Khan

et al. 2016

Acta Pharmacol Sin

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Aim: Tubeimoside-1 (TBMS1), a triterpenoid saponin extracted from the Chinese herbal medicine Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae), has shown anticancer activities in various cancer cell lines. The aim of this study was to investigate the anticancer activity and molecular targets of TBMS1 in human prostate cancer cells in vitro. Methods: DU145 and P3 human prostate cancer cells were treated with TBMS1. Cell viability and apoptosis were detected. ROS generation, mitochondrial membrane potential and cell cycle profile were examined. Western blotting was used to measure the expression of relevant proteins in the cells. Results: TBMS1 (5-100 μmol/L) significantly suppressed the viability of DU145 and P3 cells with IC 50 values of approximately 10 and 20 μmol/L, respectively. Furthermore, TBMS1 dose-dependently induced apoptosis and cell cycle arrest at G 0 /G 1 phase in DU145 and P3 cells. In DU145 cells, TBMS1 induced mitochondrial apoptosis, evidenced by ROS generation, mitochondrial dysfunction, endoplasmic reticulum stress, modulated Bcl-2 family protein and cleaved caspase-3, and activated ASK-1 and its downstream targets p38 and JNK. The G 0 /G 1 phase arrest was linked to increased expression of p53 and p21 and decreased expression of cyclin E and cdk2. Co-treatment with Z-VAD-FMK (pan-caspase inhibitor) could attenuate TBMS1-induced apoptosis but did not prevent G 0 /G 1 arrest. Moreover, co-treatment with NAC (ROS scavenger), SB203580 (p38 inhibitor), SP600125 (JNK inhibitor) or salubrinal (ER stress inhibitor) significantly attenuated TBMS1-induced apoptosis. Conclusion: TBMS1 induces oxidative stress-mediated apoptosis in DU145 human prostate cancer cells in vitro via the mitochondrial pathway.

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Section: Introductionmentioning

confidence: 99%

“…However, this treatment remains ineffective due to its toxicity to normal cells and the rapid development of resistance. Therefore, to further explore the biology of metastasis and develop novel therapeutics that specifically target metastasis and metastatic progression are required (7,8).Increasing attention has been paid to drugs among traditional Chinese medicines, since these materials typically share high safety profiles and can effectively prevent and control metastasis (9,10). Rheum palmatum L. is a plant that has been widely used in Chinese medicine as a laxative for thousands of years.…”

mentioning

confidence: 99%

Emodin inhibits migration and invasion of MHCC-97H human hepatocellular carcinoma cells

Lin

Zhong

Liang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Emodin, an anthraquinone derivative from the root and rhizome of Rheum palmatum L., was found to have antitumor effects in different types of cancer by regulating multi-molecular targets. The aim of the present study was to explore the effect of emodin on the migration and invasion of MHCC-97H human hepatocellular carcinoma cells and the underlying molecular mechanisms. Firstly, it was demonstrated that emodin can inhibit cell proliferation and induce apoptosis of cells in a time-and dose-dependent manner, using a MTT assay and flow cytometry, respectively. However, when emodin concentration was <50 µmol/l, it had little effect on the inhibition of proliferation or the induction of apoptosis. Then, it was observed that emodin can significantly suppress cell migration and invasion with a treatment dose <50 µmol/l compared with the control (P<0.05), which was not attributed to a decrease in cell number. Further study demonstrated that emodin significantly suppressed the expression levels of matrix metalloproteinase (MMP)-2 and MMP-9 compared with the control, which may be mediated by the activation of the p38 mitogen-activated protein kinases (MAPK) signaling pathway and suppression of extracellular signal regulated kinase (ERK)/MAPK and phosphatidylinositol 3-kinase/Akt signaling pathways. Therefore, the present study, for the first time, used MHCC-97H cells, which have the high potential of malignant invasion, to demonstrate that emodin may inhibit cell migration and invasion. IntroductionHepatocellular carcinoma (HCC) is one of the most frequent malignancies worldwide, representing the fifth most common cause of cancer in men and the seventh in women, and the third most frequent cause of cancer-related mortality (1-3). Globally, there are ~750,000 new cases of liver cancer reported per year (4). Although surgical resection provides better results in patients with HCC in early stages, the long-term prognosis remains unsatisfactory because many patients are diagnosed at the advanced stage, and tumors have an inherent capacity for invasiveness and metastasis (5,6). At present, chemotherapy is commonly used in the treatment of metastatic HCC. However, this treatment remains ineffective due to its toxicity to normal cells and the rapid development of resistance. Therefore, to further explore the biology of metastasis and develop novel therapeutics that specifically target metastasis and metastatic progression are required (7,8).Increasing attention has been paid to drugs among traditional Chinese medicines, since these materials typically share high safety profiles and can effectively prevent and control metastasis (9,10). Rheum palmatum L. is a plant that has been widely used in Chinese medicine as a laxative for thousands of years. Emodin is an anthraquinone derivative from its root and rhizome (11). It has been reported that emodin possesses a number of biological properties such as anti-inflammatory, antiviral and anti-proliferative effects (12). In the context of cancer, several studies have indicated...

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Three advantages of using traditional Chinese medicine to prevent and treat tumor

Cited by 167 publications

References 26 publications

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro

Emodin inhibits migration and invasion of MHCC-97H human hepatocellular carcinoma cells

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