Threats posed by xenoestrogenic chemicals to the aquatic ecosystem, fish reproduction and humans: a review

Badamasi, Inuwa; Odong, Robinson; Masembe, Charles

doi:10.2989/16085914.2020.1746233

Cited by 6 publications

(5 citation statements)

References 134 publications

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“…E2’s biological role is to regulate sexual differentiation and reproduction, though it also plays roles in tissue differentiation, inflammation control, and neurological functions [ 99 ]. These compounds that mimic E2 are called xenoestrogens (XEs) and impact normal estrogen signaling pathways, resulting in adverse health outcomes in aquatic and terrestrial species and humans [ 47 ].…”

Section: Environmental and Human Health Implications Of Edc Exposurementioning

confidence: 99%

“…Many of these chemicals enter rivers and the ocean, where they directly interact with aquatic life and disrupt endocrine responses. Humans are exposed to these EDCs from drinking water and dietary consumption of fish [ 47 ]. In this review, we explore the major classes of EDCs, their health and environmental impacts and the emergence and application of high-throughput (HT) genomics technologies and bioinformatics approaches in studying their adverse effects.…”

Section: Introductionmentioning

confidence: 99%

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Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Verga

Huff

Owens

et al. 2022

IJERPH

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Exposure to Endocrine Disrupting Chemicals (EDC) has been linked with several adverse outcomes. In this review, we examine EDCs that are pervasive in the environment and are of concern in the context of human, animal, and environmental health. We explore the consequences of EDC exposure on aquatic life, terrestrial animals, and humans. We focus on the exploitation of genomics technologies and in particular whole transcriptome sequencing. Genome-wide analyses using RNAseq provides snap shots of cellular, tissue and whole organism transcriptomes under normal physiological and EDC perturbed conditions. A global view of gene expression provides highly valuable information as it uncovers gene families or more specifically, pathways that are affected by EDC exposures, but also reveals those that are unaffected. Hypotheses about genes with unknown functions can also be formed by comparison of their expression levels with genes of known function. Risk assessment strategies leveraging genomic technologies and the development of toxicology databases are explored. Finally, we review how the Adverse Outcome Pathway (AOP) has exploited this high throughput data to provide a framework for toxicology studies.

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Section: Environmental and Human Health Implications Of Edc Exposurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Verga

Huff

Owens

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Risk of breast, endometrium, and ovary cancers in females and risk of prostate and testis cancers in males are estrogen-dependent to some extent [ 71 ]. Studies indicate a strong relation between exposure to estrogens as the principal risk factor in the development of these estrogen-mediated cancers [ 15 , 16 , 18 , 19 , 32 , 38 , 57 , 60 , 62 , 70 ].…”

Section: Association Of Xeno-estrogenic Pesticides With Endocrine-rel...mentioning

confidence: 99%

“…Amongst the harmful effects of these contaminants, xeno-estrogenicity remains one of the most enigmatic and widely reported ones to contribute towards higher morbidity and mortality [ 14 ]. These estrogen-mimicking chemicals are known to increase the transcriptional activity factors associated with the natural estrogens, thus enhancing the risk of various estrogen-mediated human disorders including cancer [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers

Kumar

Yadav

Banerjee

2022

JoX

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In recent decades, “environmental xenobiotic-mediated endocrine disruption”, especially by xeno-estrogens, has gained a lot of interest from toxicologists and environmental researchers. These estrogen-mimicking chemicals are known to cause various human disorders. Pesticides are the most heavily used harmful xenobiotic chemicals around the world. The estrogen-mimicking potential of the most widely used organochlorine pesticides is well established. However, their effect is not as clearly understood among the plethora of effects these persistent xenobiotics are known to pose on our physiological system. Estrogens are one of the principal risk modifiers of various disorders, including cancer, not only in women but in men as well. Despite the ban on these xenobiotics in some parts of the world, humans are still at apparent risk of exposure to these harmful chemicals as they are still widely persistent and likely to stay in our environment for a long time owing to their high chemical stability. The present work intends to understand how these harmful chemicals may affect the risk of the development of estrogen-mediated human cancer.

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“…Concentrations of E2 and EE2 in surface water are typically below 50 ng/L and 10 ng/L, respectively [ 1 ], but these values greatly exceed the European Union proposed annual average environmental quality standard (0.04 and 0.035 ng/L, respectively) [ 1 ]. When present in the environment, they can cause endocrine disruption and significant adverse effects on the physiological function and reproductive system in humans and animals [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Biodegradation and Metabolic Pathway of 17β-Estradiol by Rhodococcus sp. ED55

Moreira

Murgolo²,

Mascolo

et al. 2022

IJMS

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Endocrine disrupting compounds (EDCs) in the environment are considered a motif of concern, due to the widespread occurrence and potential adverse ecological and human health effects. The natural estrogen, 17β-estradiol (E2), is frequently detected in receiving water bodies after not being efficiently removed in conventional wastewater treatment plants (WWTPs), promoting a negative impact for both the aquatic ecosystem and human health. In this study, the biodegradation of E2 by Rhodococcus sp. ED55, a bacterial strain isolated from sediments of a discharge point of WWTP in Coloane, Macau, was investigated. Rhodococcus sp. ED55 was able to completely degrade 5 mg/L of E2 in 4 h in a synthetic medium. A similar degradation pattern was observed when the bacterial strain was used in wastewater collected from a WWTP, where a significant improvement in the degradation of the compound occurred. The detection and identification of 17 metabolites was achieved by means of UPLC/ESI/HRMS, which proposed a degradation pathway of E2. The acute test with luminescent marine bacterium Aliivibrio fischeri revealed the elimination of the toxicity of the treated effluent and the standardized yeast estrogenic (S-YES) assay with the recombinant strain of Saccharomyces cerevisiae revealed a decrease in the estrogenic activity of wastewater samples after biodegradation.

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Threats posed by xenoestrogenic chemicals to the aquatic ecosystem, fish reproduction and humans: a review

Cited by 6 publications

References 134 publications

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers

Biodegradation and Metabolic Pathway of 17β-Estradiol by Rhodococcus sp. ED55

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