Threat Responsiveness as a Function of Cannabis and Alcohol Use Disorder Severity

Blair, R. J. R.; White, Stuart F.; Tyler, Patrick M.; Johnson, Kimberly; Lukoff, Jennie; Thornton, Laura C.; Leiker, Emily; Filbey, Francesca M.; Dobbertin, Matt; Blair, Karina S.

doi:10.1089/cap.2019.0004

Cited by 20 publications

(22 citation statements)

References 45 publications

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“…In short, there were no indications that AUD severity relates to disruption in either the ability to represent the emotional intensity of future events or the emotional valence of future events. This is consistent with prior work from our group that has also shown that AUDIT scores were not associated with differential mPFC or PCC responsivity to emotional stimuli 26,27 . However, as a caveat to this, it is worth remembering that there was a significant AUDIT‐by‐valence‐by‐intensity interaction in the behavioral RT data; greater AUDIT scores were associated with significantly longer RTs for high‐intensity, negative valence future events than all other future events.…”

Section: Discussionsupporting

confidence: 89%

“…This is consistent with prior work from our group that has also shown that AUDIT scores were not associated with differential mPFC or PCC responsivity to emotional stimuli. 26,27 However, as a caveat to this, it is worth remembering that there was a significant AUDIT-by-valence-by-intensity interaction in the behavioral RT data; greater AUDIT scores were associated with significantly longer RTs for high-intensity, negative valence future events than all other future events. This suggests some association between greater AUD severity and issues processing at least some types of future event.…”

Section: Discussionmentioning

confidence: 91%

“…38,42,43 Indeed, recent work in a partially overlapping sample has shown that CUD symptom severity was negatively related to rmFC responsivity to looming emotional stimuli during a looming threat task. 27 Additionally, dysfunction within rmFC has been implicated in increased risky decision-making. 44 Risky decision-making is well documented in both adults and adolescents with SUDs.…”

Section: Discussionmentioning

confidence: 99%

“…For example, differential associations between AUD versus CUD symptoms in adolescents have been reported with respect to the functional integrity of neural systems engaged in reward processing, 25 executive attention, 26 and emotional responsiveness. 27 In the current study, we used a version of a comparative optimism (CO) task, developed by our group, 28,29 to examine the relationship between AUD and/or CUD symptomatology and affect-based neural representation of future events in an adolescent population. In this task, participants rate how likely they believe positively and negatively highand low-intensity valenced future events are to happen to them in the future (e.g, high-intensity positive event: winning the lottery; low intensity negative event: getting teased).…”

Section: Introductionmentioning

confidence: 99%

“…Although AUD and CUD are highly comorbid in adolescent populations, 24 recent work has begun to delineate differences in the functional impairments associated with each within adolescents. For example, differential associations between AUD versus CUD symptoms in adolescents have been reported with respect to the functional integrity of neural systems engaged in reward processing, 25 executive attention, 26 and emotional responsiveness 27 …”

Section: Introductionmentioning

confidence: 99%

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Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events

et al. 2020

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Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis use disorder (CUD) and alcohol use disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. In the current study involving 112 adolescents, we used a comparative optimism task to examine the relationship between relative severity of CUD/AUD (as indexed by the CUD/AUD Identification Tests [CUDIT/AUDIT]) and atypical function within neural systems underlying affect-based neural represenation future events. Greater CUDIT scores were negatively related to responses within subgenual anterior and posterior cingulate cortex when processing high-intensity potential future positive and negative events. There was also a particularly marked negative relationship between CUD symptoms and blood oxygen level-dependent (BOLD) responses within visual and premotor cortices to high-intensity, negatively valenced potential future events. However, AUD symptom severity was not associated with dysfunction within these brain regions. These data indicate that relative risk/severity of CUD is associated with reduced responsiveness to future high-intensity events. This may impair decisionmaking where future significant consequences should guide response choice.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 91%