Thoughts on cartilage tissue engineering: A 21st century perspective

Stampoultzis, Theofanis; Karami, Peyman; Pioletti, Dominique P.

doi:10.1016/j.retram.2021.103299

Cited by 44 publications

(37 citation statements)

References 150 publications

(130 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 In cases of acute trauma and chronic wear, articular cartilage will suffer from varying degrees of damage, oen causing joint pain, limited mobility, and even loss of function. [3][4][5] Due to the low degree of vascularization, the nutrition of cartilage tissue mainly comes from the joint uid, and its ability to regenerate is very limited if a traumatic or pathological event occurs. 6,7 Currently, the methods used to treat cartilage defects include surgeries contain microfractures, autologous osteochondral transplantation, and autologous chondrocyte implantation.…”

Section: Introductionmentioning

confidence: 99%

“…For example, collagen bers are parallel to the articular surface in the supercial regions of the articular cartilage and even perpendicular to the articular surface in the deep regions. 2,3,17 Therefore, the ideal biological material should have the ability to rebuild three-dimensional tissue and have the structure of mimicking natural cartilage tissue.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Repairing cartilage tissue remains a serious clinical challenge. The global prevalence of cartilage problems has risen rapidly in recent years, and it is expected to quadruple by 2040 (Stampoultzis et al, 2021). With the rapid breakthroughs in tissue engineering, cartilage regeneration via transplantation of artificial constructs has become a viable approach.…”

Section: Discussionmentioning

confidence: 99%

Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion

Szustak

Gendaszewska‐Darmach

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Nanocellulose deserves special attention among the large group of biocompatible biomaterials. It exhibits good mechanical properties, which qualifies it for potential use as a scaffold imitating cartilage. However, the reconstruction of cartilage is a big challenge due to this tissue's limited regenerative capacity resulting from its lack of vascularization, innervations, and sparsely distributed chondrocytes. This feature restricts the infiltration of progenitor cells into damaged sites. Unfortunately, differentiated chondrocytes are challenging to obtain, and mesenchymal stem cells have become an alternative approach to promote chondrogenesis. Importantly, nanocellulose scaffolds induce the differentiation of stem cells into chondrocyte phenotypes. In this review, we present the recent progress of nanocellulose-based scaffolds promoting the development of cartilage tissue, especially within the emphasis on chondrogenic differentiation and expansion.

show abstract

“…They are small enough to be delivered in a minimally invasive way through a syringe and needle, such as with the microspheres used for controlled release of drugs, but they are also large enough to provide a surface for cells to grow on, particularly in the case of microcarriers, or to build up 3D structures in the case of granular hydrogels. In the context of cartilage TE, the use of biomaterial scaffolds, including those based on hydrogels [24][25][26], as well as the use of nanomaterials, particularly nanoparticles used for controlled delivery [27,28], have been extensively and recently reviewed elsewhere.…”

Section: Background On Microspheres Microcarriers and Granular Hydrogelsmentioning

confidence: 99%

A Review of the Use of Microparticles for Cartilage Tissue Engineering

Kulchar

Denzer

Chavre

et al. 2021

IJMS

View full text Add to dashboard Cite

Tissue and organ failure has induced immense economic and healthcare concerns across the world. Tissue engineering is an interdisciplinary biomedical approach which aims to address the issues intrinsic to organ donation by providing an alternative strategy to tissue and organ transplantation. This review is specifically focused on cartilage tissue. Cartilage defects cannot readily regenerate, and thus research into tissue engineering approaches is relevant as a potential treatment option. Cells, scaffolds, and growth factors are three components that can be utilized to regenerate new tissue, and in particular recent advances in microparticle technology have excellent potential to revolutionize cartilage tissue regeneration. First, microspheres can be used for drug delivery by injecting them into the cartilage tissue or joint space to reduce pain and stimulate regeneration. They can also be used as controlled release systems within tissue engineering constructs. Additionally, microcarriers can act as a surface for stem cells or chondrocytes to adhere to and expand, generating large amounts of cells, which are necessary for clinically relevant cell therapies. Finally, a newer application of microparticles is to form them together into granular hydrogels to act as scaffolds for tissue engineering or to use in bioprinting. Tissue engineering has the potential to revolutionize the space of cartilage regeneration, but additional research is needed to allow for clinical translation. Microparticles are a key enabling technology in this regard.

show abstract

Thoughts on cartilage tissue engineering: A 21st century perspective

Cited by 44 publications

References 150 publications

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion

A Review of the Use of Microparticles for Cartilage Tissue Engineering

Contact Info

Product

Resources

About