Thorotrast-induced cancer in man

Baserga, Renato; Yokoo, Hidejiro; Henegar, George C.

doi:10.1002/1097-0142(196009/10)13:5<1021::aid-cncr2820130524>3.0.co;2-f

Cited by 79 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This experiment was designed like that described in a. Cells were labeled with L-valine- 1 C contents of cell pellets were determined (curve C). Glucose content of medium on day 3 was 45 % that of fresh medium.…”

Section: Incorporation Of Isotope Into Surface Membranes and Cell Parmentioning

confidence: 99%

Membranes of Animal Cells

Warren

Glick

1968

The Journal of Cell Biology

233

View full text Add to dashboard Cite

Turnover studies of the surface membrane and of cell particulate matter of L cells in tissue culture in logarithmic and plateau phase of growth have been made. The rate of incorporation of isotope into these fractions and the rate of fall of specific activities of labeled L-cell fractions have been observed. The following interpretation of the data appears most likely although other interpretations are possible. Growing and nongrowing cells synthesize approximately similar amounts of surface membrane and particulate material. In the growing cell the material is incorporated with net increases in substance. There is relatively little turnover. In the nongrowing cell newly synthesized material is incorporated, but a corresponding amount of material is eliminated so that there is turnover without net increase of substance. Our results suggest that there is no gross differential turnover between the protein, lipid, and carbohydrate of the surface membrane under the conditions of our experiments. Metabolic inhibitors or omission of amino acids in the culture medium lead to a decrease in synthesis of surface membrane and cell particulates and cause an equivalent decrease in the rate of degradation of surface membrane and of particulates; therefore the synthetic and degradative aspects of turnover appear to be coupled. As cultures of nongrowing cells in suspension or on a glass surface age, their synthetic and turnover capacities diminish. Our results suggest that the cell may exist in a nongrowing state with a level of synthesis similar to that of a growing cell. It can exist in this state with a high level of turnover.

show abstract

Section: Incorporation Of Isotope Into Surface Membranes and Cell Parmentioning

confidence: 99%

Membranes of Animal Cells

Warren

Glick

1968

The Journal of Cell Biology

233

View full text Add to dashboard Cite

show abstract

“…Hence, the possibility of genetic damage should a t least be considered. Baserga et al (9) give an extensive bibliography and a compilation of 36 known cases of malignancy in man following administration of thorotrast. The fact of the carcinogenic action of thorotrast, and its relation to the radioactivity of a2Th and decay products thereof can hardly be doubted.…”

Section: Toxicology: Radioactive Metals 249mentioning

confidence: 99%

Toxicology: Radioactive Metals

Catsch¹

1963

Annu. Rev. Pharmacol.

View full text Add to dashboard Cite

“…It can be traced to the discoveries of Marie and Pierre Curie in the late 1800s and to a publication and correspondence by Alexander Graham Bell circa 1903 (1). The ensuing quackery involving bottled radium solutions (e.g., Radithor) as the cure for almost any ailment (2), as well as associated carcinogenicity and death resulting from the casual use of radium for watch dials (3) and of thorium as a contrast agent in radiographic examinations (4), placed a stigma on the use of α-particle emitters that, to a substantial extent, persists today.…”

Section: Introductionmentioning

confidence: 99%

Targeted and Nontargeted α-Particle Therapies

McDevitt

Sgouros

Sofou

2018

Annu. Rev. Biomed. Eng.

View full text Add to dashboard Cite

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical α-particle therapy delivered by antibodies, other small molecules, and nanometer-sized particles. In addition to their unique radiopharmaceutical characteristics, the increased availability and improved radiochemistry of α-particle radionuclides have contributed to the growing recent interest in α-particle radiotherapy. Targeted therapy strategies have presented novel possibilities for the use of α-particles in the treatment of cancer. Clinical experience has already demonstrated the safe and effective use of α-particle emitters as potent tumor-selective drugs for the treatment of leukemia and metastatic disease.

show abstract

Thorotrast-induced cancer in man

Cited by 79 publications

References 17 publications

Membranes of Animal Cells

Membranes of Animal Cells

Toxicology: Radioactive Metals

Targeted and Nontargeted α-Particle Therapies

Contact Info

Product

Resources

About