Thorium colloid analysis by single particle inductively coupled plasma-mass spectrometry

Degueldre, C.

doi:10.1016/j.talanta.2003.10.016

Cited by 125 publications

(77 citation statements)

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“…The application of spICP-MS as a possible means to characterize these materials was first proposed by McCarthy and Degueldre, who cite the prior aerosol literature as well as a personal communication with B. Wernli [21]. This led a decade later to a series of key papers by Degueldre et al [1,[22][23][24][25] that established the basic methodology of the spICP-MS technique as we know it now. It was some years between the publication of these papers and the renewed interest in spICP-MS as a stand-alone method for characterizing NPs [26] and as a powerful means to further characterize size fractionated NPs [27].…”

Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

“…Considerations for the application of single particle ICP-MS for routine nanomaterial analysis Works of Kawaguchi [11], and of Degueldre [1,[22][23][24], demonstrated the feasibility of using ICP-MS for the analysis of colloids, but more work was needed to develop a technique that could provide additional meaningful information about the particles analyzed. In order to characterize and quantify unknown particles samples, several aspects of signal acquisition, data processing, and calibration must be addressed.…”

Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

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Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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From its early beginnings in characterizing aerosol particles to its recent applications for investigating natural waters and waste streams, single particle inductively coupled plasma-mass spectrometry (spICP-MS) has proven to be a powerful technique for the detection and characterization of aqueous dispersions of metal-containing nanomaterials. Combining the high-throughput of an ensemble technique with the specificity of a single particle counting technique and the elemental specificity of ICP-MS, spICP-MS is capable of rapidly providing researchers with information pertaining to size, size distribution, particle number concentration, and major elemental composition with minimal sample perturbation. Recently, advances in data acquisition, signal processing, and the implementation of alternative mass analyzers (e.g., time-of-flight) has resulted in a wider breadth of particle analyses and made significant progress toward overcoming many of the challenges in the quantitative analysis of nanoparticles. This review provides an overview of spICP-MS development from a niche technique to application for routine analysis, a discussion of the key issues for quantitative analysis, and examples of its further advancement for analysis of increasingly complex environmental and biological samples. Graphical Abstract Single particle ICP-MS workflow for the analysis of suspended nanoparticles.

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Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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“…Versions of the SP-ICP-MS concept have been used to measure metals in airborne particles [27] and to measure aerosols directly [31]. Degueldre and colleagues [32][33][34] measured laboratory-synthesized colloids in suspension and additionally developed a theoretical link between intensity and particle size. This relationship involves several poorly known parameters.…”

Section: Introductionmentioning

confidence: 99%

Detecting nanoparticulate silver using single‐particle inductively coupled plasma–mass spectrometry

Mitrano

Lesher

Bednar

et al. 2011

Enviro Toxic and Chemistry

297

226

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The environmental prevalence of engineered nanomaterials, particularly nanoparticulate silver (AgNP), is expected to increase substantially. The ubiquitous use of commercial products containing AgNP may result in their release to the environment, and the potential for ecological effects is unknown. Detecting engineered nanomaterials is one of the greatest challenges in quantifying their risks. Thus, it is imperative to develop techniques capable of measuring and characterizing exposures, while dealing with the innate difficulties of nanomaterial detection in environmental samples, such as low-engineered nanomaterial concentrations, aggregation, and complex matrices. Here the authors demonstrate the use of inductively coupled plasma-mass spectrometry, operated in a single-particle counting mode (SP-ICP-MS), to detect and quantify AgNP. In the present study, two AgNP products were measured by SP-ICP-MS, including one of precisely manufactured size and shape, as well as a commercial AgNP-containing health food product. Serial dilutions, filtration, and acidification were applied to confirm that the method detected particles. Differentiation of dissolved and particulate silver (Ag) is a feature of the technique. Analysis of two wastewater samples demonstrated the applicability of SP-ICP-MS at nanograms per liter Ag concentrations. In this pilot study, AgNP was found at 100 to 200 ng/L in the presence of 50 to 500 ng/L dissolved Ag. The method provides the analytical capability to monitor Ag and other metal and metal oxide nanoparticles in fate, transport, stability, and toxicity studies using a commonly available laboratory instrument. Rapid throughput and element specificity are additional benefits of SP-ICP-MS as a measurement tool for metal and metal oxide engineered nanoparticles.

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“…SP-ICP-MS employs the well-established, widespread, and highly sensitive method for elemental analysis, ICP-MS, but is carried out by a time-resolved analysis with shorter dwell times than that of typical ICP-MS analysis 20, 21 . Single particles enter the ICP-MS plasma and, once ionised, move through the mass analyser to the detector, detect pulse signals; each pulse represents a single-particle event that can provide valuable information about particle size and size distribution 14, 15, 22 .…”

Section: Resultsmentioning

confidence: 99%

Imaging gold nanoparticles in mouse liver by laser ablation inductively coupled plasma mass spectrometry

Wang

et al. 2017

Sci Rep

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Imaging the size distribution of metal nanoparticles (NPs) in a tissue has important implications in terms of evaluating NP toxicity. Microscopy techniques used to image tissue NPs are limited by complicated sample preparation or poor resolution. In this study, we developed a laser ablation (LA) system coupled to single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) for quantitative imaging of gold (G)NPs in tissue samples. In this system, GNPs were ablated but did not disintegrate and integrate under optimised operation conditions, which were verified by characterising LA particles by scanning electron microscopy. The feasibility of imaging size distributions in tissue was validated using reference GNPs 60 and 80 nm in size on matrix-matched kidney. A transport efficiency of 6.07% was obtained by LA-SP-ICP-MS under optimal conditions. We used this system to image 80-nm GNPs in mouse liver and the size distribution thus obtained was in accordance with that determined by nebuliser SP-ICP-MS. The images revealed that 80-nm GNPs mainly accumulate in the liver and did not obviously aggregate. Our results demonstrate that LA-SP-ICP-MS is an effective tool for evaluating the size distribution of metal NPs in tissue.

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Thorium colloid analysis by single particle inductively coupled plasma-mass spectrometry

Cited by 125 publications

References 0 publications

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Detecting nanoparticulate silver using single‐particle inductively coupled plasma–mass spectrometry

Imaging gold nanoparticles in mouse liver by laser ablation inductively coupled plasma mass spectrometry

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