Thorax: Low-Dose Contrast-enhanced Three-dimensional MR Angiography with Subsecond Temporal Resolution—Initial Results

Finn, J. Paul; Baskaran, Visveshwar; Carr, James C.; McCarthy, Richard M.; Pereles, F. Scott; Kroeker, Randall; Laub, Gerhard

doi:10.1148/radiol.2243010984

Cited by 99 publications

(60 citation statements)

References 36 publications

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“…Contrast-enhanced high-temporalresolution MR angiography of the pulmonary circulation at 3.0 T has been described previously, with results revealing that time-resolved contrastenhanced MR angiography at 3.0 T can depict the pulmonary vasculature in encouraging detail ( 14 ). Several technical approaches for acquiring time-resolved MR angiograms have been described ( 30,31 ). In our study, to increase the data acquisition speed, we used the sensitivity-encoding technique ( 32 ).…”

Section: Referencesmentioning

confidence: 97%

Combined Pulmonary Fibrosis and Emphysema: 3D Time-resolved MR Angiographic Evaluation of Pulmonary Arterial Mean Transit Time and Time to Peak Enhancement

Sergiacomi

Bolacchi²,

Cadioli³

et al. 2010

Radiology

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Purpose:To correlate conventional invasive pressure indexes of pulmonary circulation with pulmonary fi rst-order arterial mean transit time (MTT) and time to peak enhancement (TTP) measured by means of three-dimensional timeresolved magnetic resonance (MR) angiography in patients with combined pulmonary fi brosis and emphysema (CPFE). Materials and Methods:The study was institutional review board approved. All subjects involved in the study provided written informed consent. Eighteen patients with CPFE were enrolled in this study. Thirteen healthy individuals matched for age and sex served as control subjects. Three-dimensional timeresolved MR angiography was performed by using a 3.0-T MR imager. Regions of interest (ROIs) were drawn manually on fi rst-order pulmonary arteries. Within the ROIs, signal intensity-versus-time curves refl ecting the fi rst pass of the contrast agent bolus in the pulmonary vessels were obtained. MTT and TTP were calculated. Pulmonary arterial pressure and pulmonary capillary wedge pressure were measured with a double-lumen, balloon-tipped catheter that was positioned in the pulmonary artery. The mean pulmonary arterial pressure (mPAP) and the pulmonary vascular resistance (PVR) were determined. Results:MTT and TTP values were prolonged signifi cantly in patients with CPFE compared with those in the control subjects ( P , .001). Mean TTP and mean MTT correlated directly with mPAP and PVR index ( P , .005). At multiple linear regression analysis, MTT was the only factor independently associated with PVR index and mPAP. Conclusion:Three-dimensional time-resolved MR angiography enables determination of pulmonary hemodynamic parameters that correlate signifi cantly with the pulmonary hemodynamic parameters obtained with invasive methods and may represent a complementary tool for evaluating pulmonary hypertension in patients with CPFE.

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Section: Referencesmentioning

confidence: 97%

Combined Pulmonary Fibrosis and Emphysema: 3D Time-resolved MR Angiographic Evaluation of Pulmonary Arterial Mean Transit Time and Time to Peak Enhancement

Sergiacomi

Bolacchi²,

Cadioli³

et al. 2010

Radiology

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“…For applications such as pulmonary angiography, the temporally resolved volumetric approach offers a versatile set of tradeoffs to accommodate individuals with the most limited breath hold capacities. Although subsecond temporal resolution for the pulmonary arteries has been previously reported, this could only be achieved with a substantial sacrifice in through-plane resolution, such that offaxis maximum intensity projections were found not to be useful (20). Such a strategy has limited clinical utility as compared with a comprehensive volumetric approach.…”

Section: Discussionmentioning

confidence: 99%

Rapid Volumetric MRI Using Parallel Imaging With Order-of-Magnitude Accelerations and a 32-Element RF Coil Array

et al. 2005

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Rationale and Objectives-Many clinical applications of Magnetic Resonance Imaging are constrained by basic limits on imaging speed. Parallel MRI relaxes these limits by using the sensitivity patterns of arrays of radiofrequency receiver coils to encode spatial information in a manner complementary to traditional encoding with magnetic field gradients. Until now, parallel MRI has been used to achieve modest improvements in imaging speed; order-of-magnitude improvements have been elusive given fundamental losses in signal-to-noise ratio. The goal of this work was to demonstrate that, with appropriate hardware and careful SNR management, rapid volumetric imaging at high accelerations is in fact feasible.Materials and Methods-Contrast-enhanced MRI with an axial 3D spoiled gradient echo imaging sequence was performed in healthy adult subjects using a 32-element RF coil array and a prototype 32-channel MR imaging system. Large imaging volumes were prescribed, in place of traditional limited slabs targeted only to suspect regions.Results-As much as 16-fold net accelerations of imaging were achieved repeatably using this approach. The use of large 3D volumes allowed comprehensive anatomical coverage at clinically useful spatial and/or temporal resolution. The need for careful, time-consuming, and subject-specific scan prescription was also eliminated. Conclusion-The highly parallel imaging approach presented here allows previously inaccessible volumetric coverage for time-sensitive MRI examinations such as contrast-enhanced MRA, and simultaneously provides a substantially simplified imaging paradigm. The resulting capability for rapid volumetric imaging promises to combine the strengths of MRI with some of the advantages of alternative imaging modalities such as multidetector CT.

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“…Contrast-enhanced magnetic resonance angiography with gadolinium, which has comparable diagnostic accuracy to x-ray angiography in complex CHD (9), is valuable for 3D assessment of extracardiac structures such as the aorta, main and branch pulmonary arteries, pulmonary veins and collateral vessels ( Figure 1D). Time-resolved 3D contrast-enhanced magnetic resonance angiography is a newer angiographic technique that captures information about the dynamics of blood flow through the right and left heart using a small volume of contrast (10). Additionally, 3D static SSFP acquisitions may be obtained, either with single breathhold or diaphragmatic monitoring, for visualization of the coronary arteries or 3D anatomy of the whole heart and vessels.…”

Section: Abstract: Cardiovascular Magnetic Resonance; Clinical Cardimentioning

confidence: 99%

The emerging clinical role of cardiovascular magnetic resonance imaging

Kumar¹,

Patton²,

Friedrich³

2010

Canadian Journal of Cardiology

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Thorax: Low-Dose Contrast-enhanced Three-dimensional MR Angiography with Subsecond Temporal Resolution—Initial Results

Cited by 99 publications

References 36 publications

Combined Pulmonary Fibrosis and Emphysema: 3D Time-resolved MR Angiographic Evaluation of Pulmonary Arterial Mean Transit Time and Time to Peak Enhancement

Combined Pulmonary Fibrosis and Emphysema: 3D Time-resolved MR Angiographic Evaluation of Pulmonary Arterial Mean Transit Time and Time to Peak Enhancement

Rapid Volumetric MRI Using Parallel Imaging With Order-of-Magnitude Accelerations and a 32-Element RF Coil Array

The emerging clinical role of cardiovascular magnetic resonance imaging

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