“…The evidence described here derives from four single-center observational studies (16,135,142,143) that compared the safety, diagnostic yield, operative time, and postoperative course of lung biopsy via VATS with lung biopsy via open thoracotomy in patients with chILD syndrome. Our confidence in the findings is limited by the study design, risk for bias (i.e., nonconsecutive patient selection and single-center enrollment), and small sample size with few events.…”