Thoracoscopic intercostal to phrenic nerve transfer for diaphragmatic reanimation in a child with tetraplegia

Latreille, Jacob; Lindholm, Erika; Zlotolow, Dan A.; Grewal, Harsh

doi:10.1080/10790268.2019.1585706

Cited by 1 publication

(1 citation statement)

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“…Many children become successful at hemidiaphragm ventilation as they age [11,12]. Additionally, early implantation to maintain diaphragm muscle allows for the possibility of intercostal nerve transfer if there is no recovery of the right hemidiaphragm as has been done in the traumatic pediatric SCI population [13]. It is our hope that through skeletal maturation, axonal sprouting, and active diaphragmatic pacing, this patient could potentially achieve some level of ventilator independence.…”

Section: Discussionmentioning

confidence: 99%

Early use of an implantable diaphragm pacing stimulator for a child with severe acute flaccid myelitis—a case report

Edmiston

Elrick²,

Kovler³

et al. 2019

Spinal Cord Ser Cases

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Introduction Acute Flaccid Myelitis (AFM) is a recently recognized, polio-like illness of children that can be functionally devastating. Severe cases can lead to ventilatory failure. Incomplete phrenic nerve injuries in other populations has been shown to respond to diaphragmatic stimulation. We therefore proposed an early assessment for incomplete denervation by laparoscopic direct stimulation of the diaphragm and placement of a diaphragmatic pacing system to enhance diaphragm function. Case presentation A 3 year-old girl presented with AFM with clinically and electrodiagnostically severe involvement of all four limbs and muscles of respiration. Direct stimulation of the diaphragm demonstrated contraction and a diaphragmatic stimulator was placed at 3 weeks post presentation. The patient was immediately able to tolerate short bouts of reduced ventilation settings. Electromyography via the pacing wires demonstrated intact motor units consistent with partial denervation/reinnervation in the left hemidiaphragm, and no motor units in the right hemidiaphragm. At three months, she tolerated 6 h of pacing on pressure support setting. At 5 months she demonstrated larger tidal volumes with active pacing than without. Discussion In our experience, AFM patients who require chronic ventilator support are rarely able to be weaned. Despite clinical and surface electrodiagnostic evidence of complete phrenic nerve involvement, the patient’s diaphragm responded to direct stimulation. The patient preferred pacing over non-pacing times and showed improved ventilatory ability with pacing as opposed to without, though remains ventilator-dependent. These findings support augmentation of diaphragm function and possible enhanced recovery of spontaneous function.

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Section: Discussionmentioning

confidence: 99%