Thoracoscopic Findings of Malignant Melanoma

Sanno, Ken; Sugawa, Kayo; Nakano, Chihiro; Kashiwa, Kumiko

doi:10.2169/internalmedicine.49.4050

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…Of note, the thoracic CT findings in our case showed dense pleural thickening that encompassed the left hemithorax, reminiscent of malignant mesothelioma. However, as described in previous reports (13,14), this pattern of growth is rarely observed in malignant melanoma. This can lead to diagnostic challenges, especially in cases of amelanotic melanoma.…”

Section: Discussionsupporting

confidence: 70%

Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma

et al. 2019

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A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial malignant mesothelioma or lung adenocarcinoma cells; these cells were positive for melanoma-associated antigen recognized by T cells (MART-1)/Melan-A, HMB-45, and S-100 on immunocytochemistry. Thoracic computed tomography (CT) revealed marked diffuse pleural thickening in the left hemithorax that mimicked malignant mesothelioma; thus, the present report describes the unique cytological and radiological findings of this case.

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Section: Discussionsupporting

confidence: 70%

Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma

et al. 2019

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“…Most metastatic relapses occur within three years, and late metastases can occur even after ten years [6,7]. Pleural involvement, although rare, can present as pleural thickening, mimicking mesothelioma, or pleural effusion, as in the case of our patient [8].…”

Section: Discussionmentioning

confidence: 57%

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

Gomez¹,

Jospeh²,

Arangan³

et al. 2022

Cureus

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Although melanoma starts as a local disease, it can metastasize to other sites of the body including the lung, brain, liver, and intestines. However, pleural involvement is a rare presentation. Here, we present a case of a 57-year-old man with a history of stage IIA cutaneous melanoma, that relapsed 3 years after cutaneous resection, presenting with a non-resolving pleural effusion. Pleural fluid analysis was consistent with an exudative effusion, and pleural biopsy confirmed metastatic melanoma. The patient was treated with dual therapy of ipilimumab and nivolumab, as per National Comprehensive Cancer Network guidelines, with good response. Thus, we recommend having a high index of clinical suspicion for metastatic pleural melanoma when a patient with a history of cutaneous melanoma presents with a non-resolving pleural effusion.

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“…There are few reports of recurrent malignant melanoma mainly presenting with pleural effusions in the literature (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) (Table 1); all were con rmed by pathology.…”

Section: Discussionmentioning

confidence: 99%

Pleural effusion as the initial manifestation of metastatic melanoma: a case report and literature review

Quan

Qiu

et al. 2020

Preprint

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Background: Malignant melanoma (MM) is a highly invasive form of skin cancer with poor prognosis. Pleural metastatic melanoma is rare, with only a few reported cases.Case presentation: A 47-year-old woman with a medical history of right heel melanoma was diagnosed with left-sided pleural effusion, with pleural thickening and calcified mediastinal lymph nodes, using chest computed tomography (CT). A video-assisted thoracoscopic biopsy was performed which revealed numerous pink lumps arising from the parietal pleura and viscera along the diaphragmatic surface. The pathological diagnosis was pleural metastatic melanoma and the tumor cells were immunocytochemically positive for S100, SOX10, and Melan-A.Conclusions: The clinical manifestations of metastatic pleural melanoma are nonspecific. Pleural effusion cytology combined with thoracoscopy is an effective diagnostic method. The presence of melanocytes has improved the diagnosis of this condition.

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Thoracoscopic Findings of Malignant Melanoma

Cited by 3 publications

References 1 publication

Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma

Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

Pleural effusion as the initial manifestation of metastatic melanoma: a case report and literature review

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