Thoracodorsal artery aneurysm caused by fibromuscular dysplasia

Brantley, S. D.; Spies, JB

doi:10.2214/ajr.149.5.1067

Cited by 5 publications

(2 citation statements)

References 1 publication

(1 reference statement)

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“…Small molecule metabolites play a significant role in the breast tumor expansion. Warburg-like metabolism is influenced by changes in stromal-epithelial cell interactions, including metabolism related genes and epigenome [46]. Preliminary assays for metabolites has shown that EVs from hMSCs contain glutamic acid and lactic acid both of which are associated with tumor proliferation [47].…”

Section: Discussionmentioning

confidence: 99%

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

et al. 2014

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Human mesenchymal stem/stromal cells (hMSCs) have been shown to support breast cancer cell proliferation and metastasis, partly through their secretome. hMSCs have a remarkable ability to survive for long periods under stress, and their secretome is tumor supportive. In this study, we have characterized the cargo of extracellular vesicular (EV) fraction (that is in the size range of 40-150nm) of serum deprived hMSCs (SD-MSCs). Next Generation Sequencing assays were used to identify small RNA secreted in the EVs, which indicated presence of tumor supportive miRNA. Further assays demonstrated the role of miRNA-21 and 34a as tumor supportive miRNAs. Next, proteomic assays revealed the presence of ≈150 different proteins, most of which are known tumor supportive factors such as PDGFR-β, TIMP-1, and TIMP-2. Lipidomic assays verified presence of bioactive lipids such as sphingomyelin. Furthermore, metabolite assays identified the presence of lactic acid and glutamic acid in EVs. The co-injection xenograft assays using MCF-7 breast cancer cells demonstrated the tumor supportive function of these EVs. To our knowledge this is the first comprehensive -omics based study that characterized the complex cargo of extracellular vesicles secreted by hMSCs and their role in supporting breast cancers.

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Section: Discussionmentioning

confidence: 99%

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

et al. 2014

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“…Interestingly, two non-thoracoscopic related cases of TDAP have been previously described. One resulted from bromuscular dysplasia 15 while the other occurred after latissimus dorsi free ap surgery 16 .…”

Section: Discussionmentioning

confidence: 99%

Delayed Thoracodorsal Artery Pseudoaneurysm After Thoracoscopic Sympathectomy for Hyperhidrosis in an Adolescent: A Case Report

Khelif¹,

Laureys²,

Khelif³

2020

Preprint

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Background: Conversely to intercostal artery false aneurysm, thoracodorsal artery pseudoaneurysm after thoracoscopy has never been reported previously.Case presentation: We report the case of a 15-year-old male presenting a delayed thoracodorsal artery pseudoaneurysm after bilateral thoracospic sympathectomy. Diagnosis was made by Doppler Ultrasound and confirmed by computed tomography angiography. Angiographic embolization was successfully performed. Conclusion: Thoracodorsal artery pseudoaneurysm should be considered in patients presenting with a parietal thoracic mass following thoracoscopy. This is to the best of our knowledge the first report of thoracodorsal artery pseudoaneurysm after thoracoscopy.

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