Thoracic ultrasound in the diagnosis of malignant pleural effusion

Qureshi, Nagmi R.; Rahman, Najib M.; Gleeson, Fergus

doi:10.1136/thx.2008.100545

Cited by 254 publications

(203 citation statements)

References 21 publications

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“…Advances in high-throughput techniques ( proteomics, genomics) have triggered developments in the discovery of biomarkers for the disease. The use of thoracic ultrasound (TUS) in everyday practice has enhanced the diagnosis of MPE and assisted in the refinement of pleural procedures [8]. Additionally, clinical research in MPE has progressed and high-quality, suitably powered, randomised controlled trials have begun to provide a more robust evidence base for some of the treatment approaches in the field [9,10].…”

Section: Introductionmentioning

confidence: 99%

Malignant pleural effusion: from bench to bedside

et al. 2016

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Malignant pleural effusion (MPE) is a common but serious condition that is related with poor quality of life, morbidity and mortality. Its incidence and associated healthcare costs are rising and its management remains palliative, with median survival ranging from 3 to 12 months. During the last decade there has been significant progress in unravelling the pathophysiology of MPE, as well as its diagnostics, imaging, and management. Nowadays, formerly bed-ridden patients are genotyped, phenotyped, and treated on an ambulatory basis. This article attempts to provide a comprehensive overview of current advances in MPE from bench to bedside. In addition, it highlights unanswered questions in current clinical practice and suggests future directions for basic and clinical research in the field. @ERSpublications This review provides up to date knowledge for malignant pleural effusion covering aspects from bench to bedside http://ow.ly/10w7vN

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Section: Introductionmentioning

confidence: 99%

Malignant pleural effusion: from bench to bedside

et al. 2016

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“…Visualization of internal echoes, either of mobile particles or septa, is highly suggestive of exudate or hemothorax [72][73][74][75][76]. However, when faced with an anechoic effusion, the only way to differentiate between transudate and exudate is to use thoracentesis or alternatively to evaluate effusion in the clinical context [71,[77][78][79].…”

Section: Rl-d4-s2 (Strong: Level B)mentioning

confidence: 99%

International evidence-based recommendations for point-of-care lung ultrasound

et al. 2012

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Background: The purpose of this study is to provide evidence-based and expert consensus recommendations for lung ultrasound with focus on emergency and critical care settings. Methods: A multidisciplinary panel of 28 experts from eight countries was involved. Literature was reviewed from January 1966 to June 2011. Consensus members searched multiple databases including Pubmed, Medline, OVID, Embase, and others. The process used to develop these evidence-based recommendations involved two phases: determining the level of quality of evidence and developing the recommendation. The quality of evidence is assessed by the grading of recommendation, assessment, development, and evaluation (GRADE) method. However, the GRADE system does not enforce a specific method on how the panel should reach decisions during the consensus process. Our methodology committee decided to utilize the RAND appropriateness method for panel judgment and decisions/consensus. Results: Seventythree proposed statements were examined and discussed in three conferences held in Bologna, Pisa, and Rome. Each conference included two rounds of face-to-face modified Delphi technique. Anonymous panel voting followed each round. The panel did not reach an agreement and therefore did not adopt any recommendations for six statements. Weak/ conditional recommendations were made for 2 statements, and strong recommendations were made for the remaining 65 statements. The statements were then recategorized and grouped to their current format. Internal and external peer-review processes took place before submission of the recommendations. Updates will occur at least every 4 years or whenever significant major changes in evidence appear. Conclusions: This document reflects the overall results of the first consensus conference on ''point-of-care'' lung ultrasound. Statements were discussed and elaborated by experts who published the vast majority of papers on clinical use of lung ultrasound in the last 20 years. Recommendations were produced to guide implementation, development, and standardization of lung ultrasound in all relevant settings.

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“…The number was also reduced further when case reports were excluded. From May 2003 through June 2009, a total of 1 guideline, 3 2 meta-analyses, 4,5 9 literature reviews, 6-14 1 randomized controlled trial, 15 and 9 clinical studies [16][17][18][19][20][21][22][23][24] on the practical investigation and diagnosis of pleural effusion were published in peer-reviewed journals.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of Pleural Effusion: A Systematic Approach

McGrath

Anderson

2011

American Journal of Critical Care

121

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In most diseases related to pleural effusion, the fluid analysis yields important diagnostic information, and in certain cases, fluid analysis alone is enough for diagnosis. The many important characteristics of pleural fluid are described, as are other complementary investigations that can assist with the diagnosis of common and rare pleural effusions. For a systematic review of pleural effusion, a literature search for articles on the practical investigation and diagnosis of pleural effusion was done. Articles included guidelines, expert opinion, experimental and nonexperimental studies, literature reviews, and systematic reviews published from May 2003 through June 2009. The search yielded 1 guideline, 2 meta-analyses, 9 literature reviews, 1 randomized control trial, and 9 clinical studies. On the basis of class IIa or class I evidence from these articles, a step by step approach is recommended for investigating a pleural effusion, beginning with assessment of the medical history, clinical examination, radiology, pleural fluid evaluation, and finally, if no diagnosis is forthcoming, a pleural biopsy under image guidance or thoracoscopy.

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Thoracic ultrasound in the diagnosis of malignant pleural effusion

Abstract: NRQ and NMR are joint first authors with equal roles in design, delivery and publication.

Cited by 254 publications

References 21 publications

Malignant pleural effusion: from bench to bedside

Malignant pleural effusion: from bench to bedside

International evidence-based recommendations for point-of-care lung ultrasound

Diagnosis of Pleural Effusion: A Systematic Approach

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