Thoracic spinal cord injury without major bone injury associated with ossification of the ligamentum flavum

Machino, Masaaki; Imagama, Shiro; Ito, Keigo; Ando, Kei; Kato, Fumihiko; Nishida, Yoshihiro; Ishiguro, Naoki

doi:10.1016/j.jos.2016.10.002

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…OLF occurs frequently at lower thoracic levels due to certain factors: increased mechanical stress caused by the thoracic spine’s position at the intersection of the lumbar spine’s elasticity and rib cage’s rigidity, a direct link between increased spinal mobility and recurrent mild trauma, and the posterior column’s high tensile force. Three cases of thoracic spinal cord injury without major bone injury associated with OLF were reported [ 10 ]. Furthermore, following injury by a low-energy method, spinal cord injury without significant bone injury of the lower thoracic spine should be suspected in geriatric populations, especially in patients with OLF.…”

Section: Thoracic Ossification Of the Ligamentum Flavum (T-olf)mentioning

confidence: 99%

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Treatment for the Thoracic Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum

Machino

Sakai²,

Yoshii

et al. 2022

JCM

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Section: Thoracic Ossification Of the Ligamentum Flavum (T-olf)mentioning

confidence: 99%

“…Decompression surgery should therefore be considered to prevent subsequent injuries. Due to the compressive etiology in the previous study, decompression surgery was performed on all patients with T-OLF, and postoperative neurological symptoms improved [ 10 ].…”

Section: Thoracic Ossification Of the Ligamentum Flavum (T-olf)mentioning

confidence: 99%

Treatment for the Thoracic Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum

Machino

Sakai²,

Yoshii

et al. 2022

JCM

Self Cite

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“…During tension stimulation and OLF progression, skin injuries, epidermal infections, and spinal cord dysfunction may occur. 9 Before specimen collection, limb motor function of rats was assessed using the BBB (Basso DM, Beattie MS, Bresnahan JC) locomotor rating scale. 10 In short, the rats could move freely for 4 minutes in a circular field while closely observing the movement of the limbs.…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Cyclic Tensile Stress to Rat Thoracolumbar Ligamentum Flavum Inducing the Ossification of Ligamentum Flavum

Zhao

Yuan²,

Cheng³

et al. 2021

Spine

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Study Design. Western blot, reverse transcription-polymerase chain reaction (RT-PCR), radiological, and histological analyses of the rat ossification of ligamentum flavum (OLF) induced by cyclic tensile stress.Objective. The aim of this study was to induce the OLF using cyclic tensile stress to rat thoracolumbar ligamentum flavum, and to investigate the possible molecular mechanism of tensioninduced OLF. Summary of Background Data. Tensile stress has been considered as an important factor leading to the OLF. So far, however, no OLF induced by tension has been reported. Methods. Forty rats were randomly divided into five equal groups. For control groups, the blank and anesthesia groups were not subjected to tension. For experimental groups, the 4-, 8-, and 12-week groups were subjected to cyclic tensile stress of ligamentum flavum after abdominal anesthesia for 4 weeks, 8 weeks, and 12 weeks, respectively, using an original stress apparatus for rats. The radiological and morphological changes of rat spine, as well as the protein and mRNA expressions of CD44, bone morphogenetic protein-2 (BMP-2), integrin b3, collagen protein type I (COL1), osteopontin (OPN), runt-related transcription factor 2 (RUNX-2), and vascular endothelial growth factor (VEGF), were concerned. Results. The micro-CT showed OLF in the 4-, 8-, and 12-week group. The axial maximum occupied area of ossifications was 1.42 mm 2 , 3.35 mm 2 , and 7.28 mm 2 , respectively. In histopathology, chondrocytes proliferated in the experimental model; woven bone arose in the 8-and 12-week groups, and was more noticeable in the 12-week group. According to western blot and RT-PCR, the expressions of seven osteogenesis-related molecules were all increased in three experimental groups. Conclusion. Cyclic tensile stress to the ligamentum flavum in rats can induce the OLF, and the longer the duration, the more visible the osteogenesis. The upregulation and synergism of osteogenesis-related molecules may contribute to the OLF induced by tensile stress.

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Clinical progression of ossification of the ligamentum flavum in thoracic spine: a 10- to 11-year follow-up study

Fan

Sun

Chen³

et al. 2022

Eur Spine J

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Thoracic spinal cord injury without major bone injury associated with ossification of the ligamentum flavum

Cited by 5 publications

References 13 publications

Treatment for the Thoracic Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum

Treatment for the Thoracic Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum

Cyclic Tensile Stress to Rat Thoracolumbar Ligamentum Flavum Inducing the Ossification of Ligamentum Flavum

Clinical progression of ossification of the ligamentum flavum in thoracic spine: a 10- to 11-year follow-up study

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