Thoracic Epidural Anesthesia Reversed Myocardial Fibrosis in Patients With Heart Failure Caused by Dilated Cardiomyopathy

Ma, Daifu; Лю, Лэй; Zhao, Hongwei; Zhang, Ruiying; Yun, Fengxiang; Liu, Lulu; Wang, Yang; Qu, Renhai; Liu, Pengfei; Liu, Fengqi

doi:10.1053/j.jvca.2017.05.014

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…27) In addition, according to reports about the effect of neuromodulation on severe HF, TEA over conventional medical treatment could reduce the chamber dimensions and improve systolic function. 29,30) Recently, Fossay, et al reported a very interesting relationship between heart function and spinal cord injury. 31) They found that activation of the sympathetic circuitry below the level of spinal cord injury causes an increase in heart systolic function.…”

Section: Article P814mentioning

confidence: 99%

Non-Cardiac Organs Metamorphose Heart

Oshima

Fujiu

2022

Int. Heart J.

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Section: Article P814mentioning

confidence: 99%

Non-Cardiac Organs Metamorphose Heart

Oshima

Fujiu

2022

Int. Heart J.

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“…In patients with severe chronic heart failure due to dilated cardiomyopathy, the use of high TEA as an adjunct to medical treatment was associated with reduced chamber dimensions, improved systolic cardiac function and reversed myocardial fibrosis (Ma et al, 2017;Guo et al, 2012).…”

Section: Modulation Of the Cardiac Sympathetic Nervous System As A Trmentioning

confidence: 99%

“…Several arrhythmias are related to an imbalance of autonomic innervation. Blockade of cardiac sympathetic innervation improves myocardial blood flow and oxygen balance during stress https://doi.org/10.1016/j.autneu.2020.102674 Received 19 September 2019; Received in revised form 13 March 2020; Accepted 21 April 2020 (Nygard et al, 2005), and is a novel therapeutic approach for arrhythmias and heart failure (Nygard et al, 2005;Ogawa et al, 2007;Olausson et al, 1997;Do et al, 2017;Ma et al, 2017;Ajijola et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Human adult cardiac autonomic innervation: Controversies in anatomical knowledge and relevance for cardiac neuromodulation

Wink

Delft

Notenboom

et al. 2020

Autonomic Neuroscience

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Background: Cardiac sympathetic blockade is a therapeutic approach for arrhythmias and heart failure and may be a beneficial effect of high thoracic epidural anesthesia. These treatments require detailed knowledge of the spatial location and distribution of cardiac autonomic nerves, however, there are controversies on this subject in humans. Objective: To provide a systematic overview of current knowledge on human anatomy of the cardiac autonomic nervous system. Results: In contrast to the often claimed assumption that human preganglionic sympathetic cardiac neurons originate mainly from thoracic spinal segments T1-T4 or T5, there is ample evidence indicating involvement of cervical spinal segment C8 and thoracic spinal segments below T5. Whether cervical ganglia besides the stellate ganglion play a role in transmission of cardiac sympathetic signals is unclear. Similarly, there is debate on the origin of cardiac nerves from different thoracic ganglia. Most human studies report thoracic cardiac nerves emerging from the first to fourth thoracic paravertebral ganglia; others report contributions from the fifth, sixth and even the seventh thoracic ganglia. There is no agreement on the precise composition of nerve plexuses at the cardiac level. After years of debate, it is generally accepted that the vagal nerve contributes to ventricular innervation. Vagal distribution appears higher in atria, whereas adrenergic fibers exceed the number of vagal fibers in the ventricles. Conclusion: Anatomy of the human cardiac autonomic nervous system is highly variable and likely extends beyond generally assumed boundaries. This information is relevant for thoracic epidural anesthesia and procedures targeting neuronal modulation of cardiac sympathetic innervation.

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