Thoracic Chordoma: An Unusual Presentation of the Spinal Tumor

Wang, Tsai-Jung; Shu, Shu-Hsien; Chen, Lung-Fang; Lin, Ting-Chao; Chien, Hsih-Shin Chang; Lin, Chun–Wei; Lee, Ming-Yuan; Wang, Yong Alison; Huang, Chung-Jen; Liu, Chia‐Chuan

doi:10.1097/maj.0b013e3180ebeac3

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…The initial symptoms of thoracic chordoma are subtle and nonspecific. Usually, symptoms are seen with spinal cord compression or thoracic viscera compression (1,9,11,15). The second tumor of our case was at the thoracal region, T3 level.…”

Section: Discussionmentioning

confidence: 67%

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A case of chordoma invading multiple neuroaxial bones:report of ten years follow up

Aydın¹,

Sasani²,

Öktenoğlu³

et al. 2012

Turkish Neurosurgery

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AIm: Chordoma is a rare, slow-growing primary malignant tumor of the axial skeleton, arising from the embryonic cells of primitive notochord. Chordomas may arise at different sites of the vertebral column simultaneously or more probably they may metastasise along the neural axis insidiously. Recurrence despite radical surgery and following adjuvant therapy is possible. mAterIAl and methOds:A 46-year-old female patient presented weakness and numbness of the lower extremities. She was operated for clivus chordoma five years ago at another institute.results: First the patient underwent surgery for resection of the tumor at the cervical region. a second surgery was performed to resect tumor on the foramen magnum and at the C1 level. Histologic examination of the removed vertebra confirmed the diagnosis of chordoma involving the vertebral body. Radiotherapy was administered after the second surgery. Follow-up neurological and radiological examinations revealed no abnormal neurological symptoms 2,5 years after second surgery. There were no distant organ metastases.COnClusIOn: A patient with diagnosed chordoma of the spine must be investigated with MRI of other regions of the neuraxis to exclude second or even third source of chordoma metastases. In metastatic chordoma cases, radical or gross total resection should be performed for each lesion but if complete surgical resections are impossible, preoperative or postoperative radiation therapy should be planned to improve life expectancy.KeywOrds: Chordoma, Cervical tumor, Thoracal tumor, Spinal tumor, Metastasis ÖZ AmAÇ: Kordoma, omurganın ender rastlanan, yavaş ilerleyen malign karakterli bir tümörüdür. Primitif notokordun embryo hücrelerinden köken alır. Omurganın farklı bölgelerinde, birbirinden bağımsız kordoma odakları eş zamanlı olarak gelişmeye başlayabilir. Fakat daha sıklıkla, birinci tümör odağından kaynaklanan metastatik kordoma lezyonları tüm nöral aks boyunca yayılabilir. Radikal cerrahiye ve ek onkolojik tedaviye rağmen rekürens sık görülür. yÖntem ve GereÇler: Bu sunumda tartışılan 46 yaşındaki kadın hasta, bacaklarında kuvvet ve his kaybı şikayetiyle kliniğimize başvurmuştur. Hasta, beş yıl önce, ayrı bir merkezde klivus kordoması tanısıyla opere edilmiştir.BulGulAr: Hasta öncelikle servikal bölgedeki tümör için opere edilmiştir. İkinci seansta foramen magnum ve C1 seviyesindeki tümör çıkarılmıştır. Patolojik inceleme sonucunda, omurga cismini tutan kordoma lezyonu tanısı konmuştur. İkinci cerrahi seansından sonra hasta radyoterapiye yönlendirilmiştir. Bu tedaviden ikibuçuk yıl sonra yapılan değerlendirmede, hastanın nörolojik muayenesinde progresyon gözlenmemiştir.sOnuÇ: Omurganın herhangi bir lokalizasyonunda kordoma tanısı konulan bir hastada, tüm spinal bölge manyetik rezonans görüntüleme (MRG) tetkiki ile incelenmelidir. Bu hastalarda birden fazla kordoma odağına rastlanabilir. Birden fazla odak tespit edilmesi durumunda, her ayrı tümör odağı için rezeksiyon planlanmalıdır. Total rezeksiyonun mümkün olmaması durumunda, yaşam süresini uzatmak...

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Section: Discussionmentioning

confidence: 67%

“…Only imatinib mesylate has been found to have antitumor activity in patients with chordomas in a small study (3,4,15). Postoperative chemotherapy was not used in the presented case.…”

Section: Aydin Al Et Al: a Case Of Chordoma Invading Multiple Neuroamentioning

confidence: 83%

A case of chordoma invading multiple neuroaxial bones:report of ten years follow up

Aydın¹,

Sasani²,

Öktenoğlu³

et al. 2012

Turkish Neurosurgery

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“…2,5) Radiological diagnosis based on the location was gastric mucosal tumor, schwannoma, neurofibroma, ganglioneuroma, chondrosarcoma. 2) Our patient also had a slow and delayed growth in the lesion which is seen in conditions aforementioned. 2,4) .…”

Section: Discussionmentioning

confidence: 99%

“…Chordoma a rare malignant tumor of primitive notochordal origin accounts for 1-4% of all the bone malignancies. 1,2) Surveillance, Epidemiology, and End Results(SEER) database report an incidence of 0.08/100,000 population with predominance in men by 2.7/1-1.6/1 in the age group of 50-70 year. 3,4,5) Chordomas mainly involve the axial skeleton with skull base (32%), sacrum (29.2%) and mobile spine (32.8%) of which thoracic chordoma form 2-5%.…”

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confidence: 99%

Thoracic Chordoma in an Atypical Location Mimicking an Esophageal Adenocarcinoma: A Case Report

Supreeth

Cho

Kim

et al. 2020

J Korean Soc Spine Surg

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Case report. Objectives: To report a case of chordoma mimicking adenocarcinoma in a 52-year-old woman. Summary of Literature Review: Chordoma, a rare malignant tumor of primitive notochordal origin, accounts for 1-4% of all bone malignancies. Chordoma mimicking esophageal adenocarcinoma in the posterior mediastinum is unique. Materials and Methods: A 52-year-old asymptomatic woman was referred to our center with an incidentally detected posterior mediastinal mass and no significant medical history. The mass was diagnosed on a routine medical screening by esophagogastroduodenoscopy and the patient was receiving yearly follow-up. An increase in size was noticed during the second year of follow-up on endoscopic ultrasonography and the patient was referred to the Department of Gastrointestinal Surgery of our hospital. This paper was written after receiving institutional review board (IRB) approval (KC20ZASI0214). Results: En bloc resection was performed for the growing thoracic mass and pathologic findings confirmed it to be chordoma. A followup computed tomography examination was conducted at 8 months, as well as magnetic resonance imaging at 1 year, and there was no local recurrence. Conclusions: Posterior mediastinal chordoma at the thoracic level is very rare. Furthermore, it is difficult to diagnose because its immunohistochemical characteristics mimic those of esophageal adenocarcinoma, meaning that it can be missed. Management is a challenge due to its anatomical location and additional local invasion. Therefore, a multidisciplinary approach is needed, including careful consultation with the patient to provide the optimal treatment for the best possible outcome.

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“…Chordoma occurs in the sacrococcygeal spine in about 50-60% of cases. and in the base of the skull in about 15-40% of cases ( 2 , 3 ). It is a slow-growing tumor, which makes it difficult to diagnose and follow up after treatment ( 4 ).…”

Section: Discussionmentioning

confidence: 99%