Thoracic aortic computed tomography angiography in swine: establishment of a baseline for endovascular evaluation of the ascending aorta

Abstract

OBJECTIVES Our goal was to establish a baseline of computed tomography (CT) angiographic data for the porcine ascending thoracic aorta for endovascular evaluation of animal experiments and device development. METHODS Thoracic aortic CT angiography was conducted on 49 pigs with an average body weight of 60–65 kg. The CT angiographic scans were done on an imaging reconstruction workstation to obtain the specific aortic geometric data, including the diameters of the planes, the heights among the planes and the clock positions of target arteries. RESULTS Fourteen important planes were defined in the study for endograft customizing reference. The diameters of the planes were measured, and the heights among the planes were recorded. For endograft fenestrations, the right coronary artery ostium clock position was 100.11 ± 7.29°, and the brachiocephalic trunk ostium clock position was 74.72 ± 6.45°. The best projection angle of the tangent position of the left coronary artery was the right anterior oblique 17 ± 7° position. A pig with a rare congenital giant dilated aorta was found among the candidate experimental animals. CONCLUSIONS For experimental porcine models, CT angiography has proved to be a suitable imaging technique. The established baseline angiography of the swine can provide reference values for future animal experiments and device development.

Assessment of Large Animal Vascular Dimensions for Intra-Aortic Device Research and Development: A Systematic Review

“…Of the 46 selected studies, 30, 15, and 1 reported swine, ovine, and bovine data, respectively. 2 , 10 – 53 In the 1 paper we found describing bovine arterial dimensions, only thoracic aorta measurements were determined to be relevant in this study. We found no study describing aortic arch branch diameters in calves and only 1 study in sheep reporting brachiocephalic trunk diameters.…”

Impact of thoracic endovascular aortic repair on aortic biomechanics: Integration of in silico and ex vivo analysis using porcine model

“…Such an analysis can have indeed implications in the field of 3R (replacement, reduction, refinement) 42 using this in silico analysis as surrogate the porcine model used for pre-clinical tests of TEVAR endograft. 43 At the same time, the present study provides further insights on the TEVAR biomechanics. The developed experimental framework allows to measure the PWV and the corresponding results highlight that the presence of the stent-graft induces an increase of PWV underlining the stiffening of the aortic structure.…”

“…Secondly, at the best our knowledge, the present study is the first one that addresses the FEA analysis of endograft deployment in a porcine aorta. Such an analysis can have indeed implications in the field of 3R (replacement, reduction, refinement) 42 using this in silico analysis as surrogate the porcine model used for pre‐clinical tests of TEVAR endograft 43 . At the same time, the present study provides further insights on the TEVAR biomechanics.…”

Study on the Relationship between the Fluidity of Paste in Stope and the Rheological Properties of Paste

“…For plastic viscosity, when the pumping agent content exceeds 2%, the decrease begins to slow down obviously. Tao et al [6], aiming at the problems of poor rheological stability, delamination in slurry and pipe blockage caused by coarse aggregate settlement in longdistance filling slurry of pumped large double line in coal mine filling mining, measured the fluidity value and fluidity loss with time of four groups of filling slurry by using the fluidity loss experiment method. On the basis of diffusion theory, Li [7] deduced the vertical distribution formula of coarse aggregate filling slurry concentration, considering the factors of solid particle size, particle shape and density, slurry density, and yield stress.…”