Thoracic and Pulmonary Abnormalities in Multiple Myeloma

Kintzer, John S.

doi:10.1001/archinte.1978.03630290039015

Cited by 143 publications

(33 citation statements)

References 31 publications

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“…Neoplastic infiltration of the thoracic skeleton, particularly of the ribs, may interfere with chest wall mechanics. Infiltration of the lung or pleu ra by neoplastic cells has been occasionally reported [10]. Our patient did not have significant involvement of ribs and dorsal vertebrae, nor had chest x-ray and CT scan shown lung or pleural involvement.…”

Section: Discussionmentioning

confidence: 40%

Reversible Bronchial Hyperresponsiveness Induced by OK-T3/IL-2 Administration in a Patient with Multiple Myeloma

Rolla

Bucca²,

Brussino³

et al. 1995

Respiration

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Severe bronchial hyperresponsiveness to methacholine developed after intravenous therapy with OK-T3 and IL-2 in a patient with multiple myeloma, in whom no factors known to be associated with bronchial hyperresponsiveness were present. A substantial increase and activation of peripheral T-lymphocytes was observed after immunotherapy. Bronchial responsiveness and lymphocyte subsets both returned to normal baseline values 2 months after the patient was shifted to subcutaneous low dose administration of IL-2. The strict association between peripheral T-lymphocytes activation and the development of bronchial hyperresponsiveness suggests a causal relationship.

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Section: Discussionmentioning

confidence: 40%

Reversible Bronchial Hyperresponsiveness Induced by OK-T3/IL-2 Administration in a Patient with Multiple Myeloma

Rolla

Bucca²,

Brussino³

et al. 1995

Respiration

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“…10) Malignant pleural effusion in MM is extremely rare, occurring in less than 1% of patients. 4) In Korea, only two cases of myeloma with associated MPE have been reported to date, one IgG-kappa and one IgD-lambda, 3,9) and its prevalence has not been reported. In the present study, myelomatous effusion was diagnosed by detection of IgA-lambda type monoclonal immunoglobulin and atypical plasma cells in the pleural fluid.…”

Section: Discussionmentioning

confidence: 99%

“…2,3) Pleural effusion in MM has been reported in less than 6% of cases and myelomatous pleural effusion (MPE) is extremely rare (＜1%). 4,5) MPE is most commonly associated with IgA or IgG myeloma and very rarely with IgD or light chain myeloma. [6][7][8][9] Only two cases of MPE associated with MM have been reported in Korea to date: one with IgG-kappa and the other with IgD-lambda myeloma.…”

Section: Introductionmentioning

confidence: 99%

A Patient with IgA Monoclonal Gammopathy Presenting as Myelomatous Pleural Effusion with Axillary Node Involvement

Park

Sung²,

Kim

et al. 2006

Korean J Hematol

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Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin, and the neoplastic plasma cells typically accumulate in the bone marrow with occasional involvement of other organs. Pleural effusion that is associated with multiple myeloma has been infrequently reported (＜6%) and myelomatous pleural effusion is extremely rare (＜1%). A 73-year-old woman was admitted to the department of dermatology for skin lesions on both arms and both ankles. A chest radiograph taken on admission showed a nodular lesion in the right upper lung and pleural effusion. Analysis of the pleural fluid revealed many atypical plasma cells, elevated levels of IgA (27.95g/L) and lambda light chain (9.16g/L), and monoclonal IgA-lambda paraprotein on immunofixation. The serum concentrations of IgA were elevated (33.08g/L) while the concentrations of IgG and IgM were decreased. Bone marrow aspirate smears contained increased levels of immature-appearing atypical plasma cells. This is only the third case of myelomatous pleural effusion that has been reported in Korea.

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“…Extramedullary plasmacytoma (EMP) is a rare type of tumor, comprising about 4-6% of plasma cell malignancies [1,2] and occurring mostly in the neck and head regions. EMP should be differentiated from other groups of plasmacytic neoplasms, such as solitary mye- loma of bone (SMB) and multiple myeloma (MM), which are similar histologically but clinically dissimilar to EMP [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Response of the extramedullary lung plasmacytoma with pleural effusion to chemotherapy

Nagai

Ando

Yoshida

et al. 1997

Annals of Hematology

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An elderly patient with extramedullary lung plasmacytoma and subsequent pleural effusion is described. The presence of abnormal plasma cells in the pleural fluid led to diagnosis. Histologically similar conditions such as multiple myeloma and solitary myeloma of bone were ruled out by clinical evaluation. These neoplasms usually occur in the head and neck area and are not characterized by paraprotein accumulation. Few cases in the lung have been reported. We describe a case of extramedullary plasmacytoma of the lung with plasmacytoma-induced pleural effusion and the presence of monoclonal paraprotein in both the serum and urine. Chemotherapy with melphalan was effective in reducing the size of the plasmacytoma, and pleurodesis was used to manage the pleural effusion.

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Thoracic and Pulmonary Abnormalities in Multiple Myeloma

Cited by 143 publications

References 31 publications

Reversible Bronchial Hyperresponsiveness Induced by OK-T3/IL-2 Administration in a Patient with Multiple Myeloma

Reversible Bronchial Hyperresponsiveness Induced by OK-T3/IL-2 Administration in a Patient with Multiple Myeloma

A Patient with IgA Monoclonal Gammopathy Presenting as Myelomatous Pleural Effusion with Axillary Node Involvement

Response of the extramedullary lung plasmacytoma with pleural effusion to chemotherapy

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