Thoracic and Abdominal Lymphatic Pump Techniques Inhibit the Growth ofS. pneumoniaeBacteria in the Lungs of Rats

Abstract

Our data demonstrate that LPT may protect against pneumonia by inhibiting bacterial growth in the lung; however, the mechanism of protection is unclear. Once these mechanisms are understood, LPT can be optimally applied to patients with pneumonia, which may substantially reduce morbidity, mortality, and frequency of hospitalization.

Integrating osteopathic approaches based on biopsychosocial therapeutic mechanisms. Part 2: Clinical approach

“…It is important to realise that, while basic or primary experimental research may support the plausibility of a variety of mechanisms that produce changes to the tissues or nervous system, there remains a lack of clinical evidence that establishes these changes as relevant and meaningful to clinical outcomes in patients. Some of these plausible, but speculative, therapeutic mechanisms affecting the tissues include drainage of tissue fluids and pro-inflammatory metabolites from injured joints and tissues [21][22][23], short-term changes in joint pressure and motion due to joint tribonucleation and cavitation [24,25], manipulation of extrapped zygapophyseal meniscoid folds [24,26], promotion of tissue healing and collagen remodelling following injury [27][28][29], reduced thickness (densification) and improved viscosity of the loose connective tissue layer in deep fascia [30,31], mechanotransduction 5 and anti-inflammatory cellular responses of fibroblasts [32][33][34][35][36], improvement in sensory motor integration [37][38][39] and proprioception [40][41][42][43], parasympathetic responses following gentle techniques to the neck and head [44][45][46], and increased lymph flux, circulating lymphocytes, and immunity from abdominal lymphatic pump techniques [47][48][49][50].…”

Osteopathic Manipulative Therapy Induces Early Plasma Cytokine Release and Mobilization of a Population of Blood Dendritic Cells

“…By using an animal experimental dog model, these researchers showed that OMT can exert a mechanotransduction stimulus that is capable of modifying immune parameters. In addition, a recent publication from the same lab showed that thoracic and abdominal lymphatic pump techniques were able to reduce Streptococcus pneumoniae colony-forming units in the lungs of rats with acute pneumonia [25] . Although no identification of the particular mechanism responsible for this effect has yet been determined, this data clearly highlights the capability of OMT to enhance protection against infection.…”

An Osteopathic Modular Approach to Asthma: A Narrative Review

“…BLT and the other OMT techniques may be performed several times, as needed, when the patient remains dyspneic and struggles to breathe. 51 Guiney et al 28 conducted an RCT using rib raising, muscle energy, and myofascial release in an OMT sequence that resulted in notable improvements (25%-70%) in patients' peak expiratory flow (PEF) rates in 90 female pediatric patients' peak expiratory flow rates and, ultimately, chest wall motion. 34 Direct and indirect inhibition of parasympathetic tone has been described by osteopathic physicians for over a century as an asthma management.…”

“…63 Although OMT did not change vital capacity or residual volume in preliminary studies reported by Allen and D'Alonzo, 23 improved work capacity, arterial carbon dioxide tension, oxygen saturation, total lung capacity, and residual volume, as well as reduced dyspnea and fewer upper respiratory tract infections, have been demonstrated from OMT elsewhere. Creasy et al 51 demonstrated that diaphragmatic movement is a crucial element in maintaining lymph and vascular flow in the thoracic and abdominal spaces. In the supplemental videos accompanying this manuscript, we demonstrate thoracic pump and diaphragm doming techniques for addressing these mechanisms.…”