Thomas K. Jeffers: pioneer of coccidiosis research

Chapman, H. D.

doi:10.1080/03079457.2012.657608

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…The work of poultry coccidia and coccidiosis was started in 1920s and at the beginning of 1930s. The scientists paved the basis for primary knowledge as in the form of speciation, pathogenicity, lifecycles, host specificity, introduction of protective immunity and prophylaxis by vaccination and chemotherapy [6]. About 50 years ago, a live vaccine was introduced in the USA of wild type.…”

Section: Introductionmentioning

confidence: 99%

Brief History and Advancements of Vaccination Against Avian Coccidiosis: A Review

2021

Sci. Lett.

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Coccidiosis is a major protozoal disease that severely affects livestock and other animals, especially poultry. Seven species of Eimeria cause avian coccidiosis in poultry and evolve from the epithelial cells of intestine, readily induce illness and cause death to a varying extent. Prophylactic chemotherapy was a dominant choice for the control of coccidiosis but resistance to the drug was a major factor of therapy failure. Protective immunity was produced in chickens with any of Eimeria species as only species-specific immunity can be produced by recently used vaccines. Attenuation can be achieved by the serial passages in all seven Eimeria species. In chicken, the first attempt against coccidiosis caused the introduction of live oocysts, the basis of which led to the discovery of ﬁrst live attenuated commercial vaccine, Paracox1. As the emerged recombinant vaccines were replaced as a first choice, there is still a dire need to do more work on new techniques like DNA vaccine formulation along with the role of dendritic cells to produce immunity and cross-protection against avian coccidiosis. This article describes step-by-step developments in the vaccination process from the last 70 years along with a brief discussion on novel techniques to induce immunity against coccidiosis.

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Section: Introductionmentioning

confidence: 99%

Brief History and Advancements of Vaccination Against Avian Coccidiosis: A Review

2021

Sci. Lett.

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“…These innovative studies laid the basis for the subsequent extensive work on all seven species of avian Eimeria done elsewhere in the 1980s and for the introduction of the first live attenuated vaccines that are used so successfully today. The pioneering contributions of Tom Jeffers to studies on Eimeria biology and control are described by Chapman in an accompanying review (Chapman, 2012).…”

Section: Setting the Scenementioning

confidence: 99%

The long view: a selective review of 40 years of coccidiosis research

Shirley¹,

Lillehoj

2012

Avian Pathology

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This selective review of 40 years of coccidiosis research is one of a number on important diseases of poultry to celebrate the 40th anniversary of the birth of Avian Pathology, the journal of the World Veterinary Poultry Association, and is written for the non-specialist. The intention is to provide a flavour of the field problems and intellectual challenges, with emphasis in the areas of immunology and vaccinology that drove research in the 1970s, and to reflect on research progress since.

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Effect of diclazuril on intestinal morphology and SIgA expression in chicken infected with Eimeria tenella

et al. 2014

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Secretory immunoglobulin A (SIgA), as a vital actor involving in the mucosal immunity, plays a key role in defending a variety of pathogenic infections, such as bacteria, viruses and parasites. Eimeria tenella is an obligate intracellular apicomplexan parasite contacting with the digestive tract mucosa and specially parasitizes chicken caecum, causing a severe form of coccidiosis. Coccidiosis is currently mainly controlled using chemotherapeutic agents. Diclazuril, a classic coccidiostat, was used widely in the poultry industry. Because of the rising problem of drug resistance, it is therefore crucial to understand the pattern of the SIgA expression in the action of diclazuril against E. tenella. In this study, the intestinal morphology in the caecum was analyzed by haematoxylin-eosin (HE) staining, and the SIgA expression was examined by immunohistochemical technique. At the same time, the duodenum, jejunum and ileum tissues have also been evaluated. HE staining results showed that E. tenella infection caused severe damage characterized by structural disorder, haemorrhage, inflammatory cell infiltration, serous and fibrinous exudation in chicken caecum and invisible damage in the duodenum, jejunum and ileum. With the treatment of diclazuril, the damage in the caecum was alleviated obviously. Immunohistochemical analysis demonstrated that the SIgA level in the infected group was increased in the duodenum (p < 0.05), jejunum and ileum, respectively, but decreased (p < 0.01) in the caecum, compared with the control group. Interestingly, the SIgA level was decreased in the duodenum (p < 0.05), jejunum and ileum but increased (p < 0.05) in the caecum in the infected/diclazuril group in comparison to the infected group. The results showed that diclazuril effectively alleviated the damage in the caecum induced by E. tenella and provided a cure for coccidiosis by improving the immune function in chickens.

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Thomas K. Jeffers: pioneer of coccidiosis research

Cited by 4 publications

References 38 publications

Brief History and Advancements of Vaccination Against Avian Coccidiosis: A Review

Brief History and Advancements of Vaccination Against Avian Coccidiosis: A Review

The long view: a selective review of 40 years of coccidiosis research

Effect of diclazuril on intestinal morphology and SIgA expression in chicken infected with Eimeria tenella

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