Thixotropic properties of whole blood from healthy human subjects

Huang, Ching‐Rong; Pan, W.D.; Chen, H.Q.; Copley, Alfred L.

doi:10.3233/bir-1987-24630

Cited by 29 publications

(18 citation statements)

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“…However, the non-Newtonian behavior is most evident at very low shear rates when the red blood cells clump together into larger particles. According to Berger and Jou [1] and Huang et al [18], the shear rates fall below that asymptotic level when the viscosity of blood increases and the non-Newtonian properties of blood are exhibited, especially when the shear rates drop below 10 s −1 . Blood also exhibits non-Newtonian behavior in small branches and capillaries, where the cells squeeze through microvasculature and a cell-free skimming layer reduces the effective viscosity through the tube.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile Non-Newtonian Laminar Blood Flows through Arterial Double Stenoses

2014

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The paper presents a numerical investigation of non-Newtonian modeling effects on unsteady periodic flows in a two-dimensional (2D) pipe with two idealized stenoses of 75% and 50% degrees, respectively. The governing Navier-Stokes equations have been modified using the Cartesian curvilinear coordinates to handle complex geometries. The investigation has been carried out to characterize four different non-Newtonian constitutive equations of blood, namely, the (i) Carreau, (ii) Cross, (iii) Modified Casson, and (iv) Quemada models. The Newtonian model has also been analyzed to study the physics of fluid and the results are compared with the non-Newtonian viscosity models. The numerical results are represented in terms of streamwise velocity, pressure distribution, and wall shear stress (WSS) as well as the vorticity, streamlines, and vector plots indicating recirculation zones at the poststenotic region. The results of this study demonstrate a lower risk of thrombogenesis at the downstream of stenoses and inadequate blood supply to different organs of human body in the Newtonian model compared to the non-Newtonian ones.

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Section: Introductionmentioning

confidence: 99%

Pulsatile Non-Newtonian Laminar Blood Flows through Arterial Double Stenoses

2014

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“…The matrix inversion process can be computationally intense, and if deconvolution is employed, it can amplify noise in the image [14]. Moreover, the system matrix estimate is often acquired from nanoparticles in water, which may not match the viscosity of blood, a thixotropic fluid [15]. Further, blood viscosity is known to decrease by about 35% [16] from larger vessels (0.5 mm in diameter) to capillaries (40 microns in diameter) due to the Fåhræus–Lindqvist effect.…”

Section: Introductionmentioning

confidence: 99%

Linearity and Shift Invariance for Quantitative Magnetic Particle Imaging

Goodwill

Sarıtaş

et al. 2013

IEEE Trans. Med. Imaging

131

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Magnetic Particle Imaging (MPI) is a promising tracer imaging modality that employs a kidney-safe contrast agent and does not use ionizing radiation. MPI already shows high contrast and sensitivity in small animal imaging, with great potential for many clinical applications, including angiography, cancer detection, inflammation imaging, and treatment monitoring. Currently, almost all clinically relevant imaging techniques can be modeled as systems with linearity and shift invariance (LSI), characteristics crucial for quantification and diagnostic utility. In theory, MPI has been proven to be LSI. However, in practice, high-pass filters designed to remove unavoidable direct feedthrough interference also remove information crucial to ensuring LSI in MPI scans. In this work, we present a complete theoretical and experimental description of the image artifacts from filtering. We then propose and validate a robust algorithm to completely restore the lost information for the x-space MPI method. We provide the theoretical, simulated, and experimental proof that our algorithm indeed restores the LSI properties of MPI.

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“…The thixotropic nature of blood stems from the aggregation/disaggregation of rouleaux which is governed by its own time scales affected by the concentration of plasma proteins [42] and hematocrit [9]. In particular, the yield stress in dense, soft colloidal suspensions such as blood is typically attributed to an internal structure that develops, deforms, and decays in a way that depends critically not only on the current flow kinematics but also on its deformation history, thus giving rise to thixotropy [9,21,43,44]. Some of the first reports were those of Lacombe and Quemada [21,45], who focused on the description of these transient blood flow phenomena.…”

Section: Introductionmentioning

confidence: 99%

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions

et al. 2020

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This work focuses on the advanced modeling of the thixotropic nature of blood, coupled with an elasto-visco-plastic formulation by invoking a consistent and validated model for TEVP materials. The proposed model has been verified for the adequate description of the rheological behavior of suspensions, introducing a scalar variable that describes dynamically the level of internal microstructure of rouleaux at any instance, capturing accurately the aggregation and disaggregation mechanisms of the RBCs. Also, a non-linear fitting is adopted for the definition of the model’s parameters on limited available experimental data of steady and transient rheometric flows of blood samples. We present the predictability of the new model in various steady and transient rheometric flows, including startup shear, rectangular shear steps, shear cessation, triangular shear steps and LAOS tests. Our model provides predictions for the elasto-thixotropic mechanism in startup shear flows, demonstrating a non-monotonic relationship of the thixotropic index on the shear-rate. The intermittent shear step test reveals the dynamics of the structural reconstruction, which in turn is associated with the aggregation process. Moreover, our model offers robust predictions for less examined tests such as uniaxial elongation, in which normal stress was found to have considerable contribution. Apart from the integrated modeling of blood rheological complexity, our implementation is adequate for multi-dimensional simulations due to its tensorial formalism accomplished with a single time scale for the thixotropic effects, resulting in a low computational cost compared to other TEVP models.

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Thixotropic properties of whole blood from healthy human subjects

Cited by 29 publications

References 0 publications

Pulsatile Non-Newtonian Laminar Blood Flows through Arterial Double Stenoses

Pulsatile Non-Newtonian Laminar Blood Flows through Arterial Double Stenoses

Linearity and Shift Invariance for Quantitative Magnetic Particle Imaging

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions

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