This letter was referred to Charles Osterman who, with Willie Andersen, wrote the following reply

Abstract

of Prescribing Information DESCRIPTION Hepatitis B Immune Globulin (Human)-HyperHep*"-is a sterile solution of immunoglobulin (15-18% protein) which is prepared by cold alcohol fractionation from pooled venous plasma of individuals with high titers of antibody to the hepatitis B surface antigen (anti-HBs). The product is stabilized with 0.3 M glycine and contains 1:10,000 Thimerosal (a mercury derivative) as a preservative. The solution has a pH of 6.B ±0.4 adjusted with sodium carbonate. Each vial contains anti-HBs antibody equivalent to or exceeding the potency of anti-HBs in a U.S. reference hepatitis B immune'globulin (Bureau of Biologies, FDA). The product is prepared from units of human plasma that have been tested and found non-reactive for hepatitis B surface antigen.