“…To complete the picture, therapeutic monoclonal antibodies also failed to make a significant medical impact when they were first developed in the 1970s [5]. Their advent gave rise to various new tools in biomedical research and created an expectation that antibodies would provide an immediate and major breakthrough in the treatment of cancer, but then a number of drawbacks were identified and confidence was shaken.…”
We all failed because, despite generating promising results, these first-generation concepts followed a monocausal approach that used artificial models and underestimated the versatility of tumor metabolism, as well as pharmacokinetic requirements."
“…To complete the picture, therapeutic monoclonal antibodies also failed to make a significant medical impact when they were first developed in the 1970s [5]. Their advent gave rise to various new tools in biomedical research and created an expectation that antibodies would provide an immediate and major breakthrough in the treatment of cancer, but then a number of drawbacks were identified and confidence was shaken.…”
We all failed because, despite generating promising results, these first-generation concepts followed a monocausal approach that used artificial models and underestimated the versatility of tumor metabolism, as well as pharmacokinetic requirements."
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