Thirty-day postoperative outcome of patients with non-traumatic gastroduodenal perforations in southwestern Uganda

Okidi, Ronald; Sambo, Vanusa Da Consolação; Ogwang, Martin D.; Mutiibwa, David; Benitez, Noralis Portal; Bongomin, Felix

doi:10.1177/0049475519887654

Cited by 6 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies by Pescatore et al [7] and Tokunaga et al [8] showed the highest H. pylori prevalence among patients with GDP and ranged from 92% to 100% (n = 119 patients), compared to the other studies that showed a prevalence of infection between 20 and 84.6% (n = 1457) [9][10][11][12][13][14][15][16]. Two of the studies reported the lowest prevalence of H. pylori infection, with 12.5% among a total number of 48 patients and 13.8% among 29 patients with a perforated peptic ulcer, which could be due to the small sample size of both studies [3,17]. 2020) [3] The association between H. pylori and a perforated gastroduodenal ulcer.…”

Section: The Prevalence Of H Pylori Infection Among Patients With Gas...mentioning

confidence: 87%

The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

Amalia,

Vidyani,

I’tishom

et al. 2024

JCM

View full text Add to dashboard Cite

(1) Background: Gastroduodenal perforation (GDP) is a life-threatening condition caused by a spontaneous or traumatic event. Treatment should be based on the mechanism of damage, timing, location, extent of the injury, and the patient’s clinical condition. We aimed to examine several etiologic factors associated with gastroduodenal perforation and to search for the best method(s) for its prevention and treatment. (2) Methods: We conducted extensive literature reviews by searching numerous studies obtained from PubMed, Science Direct, and Cochrane for the following keywords: gastroduodenal perforation, Helicobacter pylori, NSAIDs’ use, side effects of GDP, laparoscopy, and surgery. The primary outcome was the reported occurrence of GDP. (3) Results: Using keywords, 883 articles were identified. After applying the inclusion and exclusion criteria, 53 studies were eligible for the current analyses, with a total number of 34,692 gastroduodenal perforation cases. Even though the risk factors of gastroduodenal perforation are various, the prevalence of H. pylori among patients with perforation is considerably high. As technology develops, the treatment for gastric perforation will also improve, with laparoscopic surgery having a lower mortality and complication rate compared to open surgery for GDP treatment. (4) Conclusions: H. pylori infection plays the most significant role in GDP, more than NSAIDs, surgery, chemotherapy, or transplantation. Treatment of H. pylori infection is essential to decrease the prevalence of GDP and speed up its recovery. However, urgent cases require immediate intervention, such as laparoscopic or open surgery.

show abstract

Section: The Prevalence Of H Pylori Infection Among Patients With Gas...mentioning

confidence: 87%

The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

Amalia,

Vidyani,

I’tishom

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…The fluid prescriptions that follow, will be according to fluid balance chart. Other post-operative instructions will include; IV ceftriaxone 2g once a day (OD) for 5 days, IV metronidazole 500mg 8 hourly for 5 days, IV Omeprazole 40mg OD till oral feeding is initiated, IV Paracetamol 1g 8 hourly till oral feeding is initiated, Oral warm water will be started on first POD, early removal of NGT will be done, ambulation will be encouraged from first POD [ 14 25 ]. In addition to the above, patients in group A will receive chewing gum and below is a clear instruction on how they will use it.…”

Section: Methodsmentioning

confidence: 99%

“…ERAS protocols have been proven to reduce POI duration in elective surgeries but data about such protocols in emergency surgeries is lacking [ 24 ]. The elements of ERAS recommended for reduction of POI in emergency surgeries, have been based on law risk patients [ 5 24 ], yet most of the patients in resource limited countries present late with a high risk of peritonitis and morbidity [ 25 ]. More so, some doctors avoid early feeding in fear of the complications since up to 20% of the patients do not tolerate it [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chewing Gum on Duration of Postoperative Ileus Following Laparotomy for Gastroduodenal Perforations: Protocol for a Randomized Controlled Trial

Muhumuza¹,

Molen²,

Mauricio³

et al. 2023

International Journal of Surgery Protocols

View full text Add to dashboard Cite

Background: Prolonged post-operative ileus is associated with increased risk of other complications, length of hospital stays and health care related costs. Chewing gum has been shown to reduce duration of ileus in many elective surgeries, but there is a paucity of randomised controlled trials (RCTs) on its effect on duration of ileus among patients undergoing emergency surgery, specifically patients with peritonitis. The aim of this study is to determine the effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations.Methods: This will be a randomised controlled trial done in 3 hospitals. Fifty-two patients will be randomised to 2 groups. Group A will receive chewing gum in addition to routine care, whereas group B will receive routine care only. The duration of postoperative ileus in the two groups which is the primary outcome, will be compared using the independent samples t-test in SPSS version 22. The length of hospital stay, in-hospital morbidity and mortality will be the secondary outcomes. This trial has been approved by Kampala International University research and Ethics committee (Ref No. KIU-2021-60) and Uganda national council of science and technology (Ref No. HS1665ES). Retrospective registration with the research registry has also been done (UIN: researchregistry8565). Highlights• Prolonged post-operative ileus significantly contributes to adverse surgical outcomes• Chewing gum has been shown to reduce duration of ileus in many elective surgeries• There is paucity of RCTs on role of chewing gum following surgery for peritonitis

show abstract

“…Secondary peritonitis is associated with complications such as surgical sites infection, bust abdomen, re-laparotomy, prolonged hospitalization, morbidity and mortality (2,7).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial susceptibility patterns and factors associated with secondary peritonitis among patients with acute abdomen: a cross-sectional study

Godefroy

Muhumuza

Molen

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: Secondary peritonitis is the second leading cause of sepsis worldwide. Drug-resistance to peritoneal cavity bacterial infection remains a public health threat especially in resource limited settings of Africa including Uganda. This study was aimed at determining the antibacterial susceptibility patterns and factors associated with secondary peritonitis among patients with acute abdomen who underwent surgery at a Regional Referral Hospital in Uganda. Methods: This was a cross sectional study conducted at Hoima Regional Referral Hospital (HRRH) that enrolled 126 patients with acute abdomen. After laparotomy, clinical samples were aseptically collected from patients with secondary peritonitis for culture and sensitivity using standard Microbiological methods. Binary logistic regression was used to identify factors associated with secondary peritonitis among patients with acute abdomen. Results: Majority of the patients were males (61.9%) with a mean age of 37.9(SD +/- 21.8). Secondary peritonitis was found in 57(45.2%) of the patients. Gram-negative bacteria were the most commonly isolated organisms with Escherichia coli (35.8%) and Klebsiella spp (17.0%) predominating. Imipenem 88.8%(8/9), Amikacin 88.8%(8/9), Ciprofloxacin 44.4%(4/9) and Gentamicin 44.4%(4/9) demonstrated sensitivity to the different isolated organism at varying degrees. Being a male (AOR = 3.658; 95% CI = 1.570–8.519, p = 0.003) and presenting 3 days after onset of symptoms (AOR = 2.957; 95%CI = 1.232–7.099, p = 0.015) were independently associated with secondary peritonitis. Conclusion Imipenem, Amikacin, Ciprofloxacin and Gentamicin should be considered for empirical therapy in cases of secondary peritonitis. Patients, more especially males with abdominal pain should be encouraged to present early to the hospital in order to minimise progression to secondary peritonitis.

show abstract

Thirty-day postoperative outcome of patients with non-traumatic gastroduodenal perforations in southwestern Uganda

Cited by 6 publications

References 12 publications

The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

Effect of Chewing Gum on Duration of Postoperative Ileus Following Laparotomy for Gastroduodenal Perforations: Protocol for a Randomized Controlled Trial

Antibacterial susceptibility patterns and factors associated with secondary peritonitis among patients with acute abdomen: a cross-sectional study

Contact Info

Product

Resources

About