Thirty-day operative mortality for thoracotomy in lung cancer

Wada, Hiromi; Nakamura, Takayuki; Nakamoto, Kenbu; Maeda, Masazumi; Watanabe, Yoh

doi:10.1016/s0022-5223(98)70444-1

Cited by 213 publications

(112 citation statements)

References 13 publications

(29 reference statements)

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“…Such complications are significant as they prolong hospitalization and have a major adverse impact on patients [13]. Similarly, a retrospective multicenter series from Japan by Wada et al [14] on 7,000 resections showed a 1.3% mortality rate overall and a 3.2% mortality rate after pneumonectomy.…”

Section: Surgery Mortalitymentioning

confidence: 98%

Critical Review of Nonsurgical Treatment Options for Stage I Non-Small Cell Lung Cancer

et al. 2008

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After completing this course, the reader will be able to:1. Discuss the current results obtained with primary resection in stage I NSCLC.2. Describe clinical outcomes with nonsurgical techniques such as stereotactic radiation therapy and radiofrequency ablation.3. Identify potential advantages and drawbacks of these nonsurgical techniques.4. Assess which patients would benefit most from these techniques.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTSurgery has traditionally been regarded as the treatment of choice for patients with stage I non-small cell lung cancer. However, the morbidity and mortality associated with surgery in elderly patients with considerable comorbidity remains of concern, as are the poor 5-year survival rates. Until recently, conventional radiation therapy was the only alternative curative treatment option for patients who were unfit for surgery, but with lower local control rates that were inferior to those with surgery. However, a growing body of clinical data on outcomes with newer nonsurgical treatment options such as stereotactic radiation therapy (SRT) and radiofrequency ablation (RFA) is now available.SRT is a noninvasive method showing a 2-year local control rate in excess of 85% in both T1 and T2 tumors after three to eight fractions of high-precision radiotherapy. Despite the use of very high radiation doses, high-grade toxicity is limited to approximately 5% of patients. Percutaneous RFA is an invasive method showing 2-year local control rates of approximately 64% in smaller tumors, but results are poorer in lesions >3 cm. Compared with SRT, a higher procedure-related morbidity and mortality rate has been reported, mainly caused by pneumothorax and hemorrhage. Although data from randomized trials of conventional radiotherapy versus SRT or RFA are not available, the use of SRT is becoming widespread

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Section: Surgery Mortalitymentioning

confidence: 98%

Critical Review of Nonsurgical Treatment Options for Stage I Non-Small Cell Lung Cancer

et al. 2008

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“…[15,16] In this study, although the overall lung resection mortality rate in our hospital was not included in the data, the mortality rates for lobectomies and pneumonectomies in the ICU were 18.9% and 30.0%, respectively. We previously found that postoperative respiratory failure was affected independently by the type of surgery and that the demand for mechanical ventilation was correlated with advanced disease and lower PFT scores.…”

Section: Discussionmentioning

confidence: 91%

A comparison of the intensive care unit outcomes of pneumonectomy and lobectomy patients with lung cancer

Moçin¹

2015

Turk Gogus Kalp Dama

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“…Elderly patients usually had poorly medical and physiological status. [17][18] Differences in surgical morbidity and mortality for elderly patients might be due of increased incidence of coexisting cardiopulmonary or cerebrovascular diseases [19][20][21] and resultant compromised pulmonary and cardiovascular function. 1) Age-related deterioration of pulmonary function does not usually produce symptoms in unstressed individuals.…”

Section: Discussionmentioning

confidence: 99%

“…34) Given that the average life expectancy of a person at 75 years of age exceeds 8 years, 3,20) life limiting factor for patients with early stage lung cancer at the age of 75 years or even older may not be their age, but, instead, the cancer status. Several studies had ever demonstrated benefits of active therapy in elderly population and comparable results between two cohort patients.…”

Section: Discussionmentioning

confidence: 99%

Surgery for Elderly Lung Cancer

Liu

Huang

et al. 2013

ATCS

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Objective: There are still controversies about the surgical benefits for elderly lung cancer. The aims of this study were to assess impacts of aging for non-small cell lung cancer (NSCLC) following pulmonary resection. Methods: A retrospective study was undertaken for patients operated at a curative intent from January 1998 to October 2008. Patients were divided into two groups: Group 1 consisted of patients aged at least 75 years old, and group 2 were patients less than 75 years old. Perioperative characteristics and details, hospital courses, surgery-related morbidities, surgical mortality, and survival were compared between groups. Results: Of 442 eligible patients, 73 patients (16.5%) were in group 1 (mean age 78.3 years) and 369 (83.5%) patients were in group 2 (mean age 62.5 years). The following data were compared with statistical significance: hospital stay (17.8 vs. 8.9 days), mortality rate (8.2 vs. 2.2%), morbidity rate (26.0 vs. 13.3%), and length in intensive care unit (5.7 vs. 3.2 days). The main causes for morbidities in group 1 showed cardiopulmonaryrelated. Tumor stage without considering age had statistically significant influence on survival. Survivals of two groups were comparative. (p = 0.10) Intriguingly, the disease-related survival (28.3 months; p = 0.008) and progression-free survival (25.0 months; p <0.001) in group 1 were significantly better than group 2 (20.2 and 12.2 months). Conclusions: Although operation for NSCLC in the elderly patients causes more complications, especially in the cardiopulmonary system, their outcome showed better than their younger counterparts. Pulmonary resection for elderly patients may get longer disease control. Elderly patients with physical fit for surgery should not be considered as a contraindication to pulmonary resection based on age alone.

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Thirty-day operative mortality for thoracotomy in lung cancer

Abstract: The operative mortality in Japan for thoracotomy in lung cancer was satisfactorily low. The results of this study on a large population could serve as a standard when discussing the operative outcome of lung cancer.

Cited by 213 publications

References 13 publications

Critical Review of Nonsurgical Treatment Options for Stage I Non-Small Cell Lung Cancer

Critical Review of Nonsurgical Treatment Options for Stage I Non-Small Cell Lung Cancer

A comparison of the intensive care unit outcomes of pneumonectomy and lobectomy patients with lung cancer

Surgery for Elderly Lung Cancer

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