Thirteen-week inhalation toxicity study of 1-methylnaphthalene in F344 rats

Kim, Yong-Soon; Lee, Mi-Ju; Seo, Dong-Suk; Kim, Tae Hyun; Kim, Min-Ha; Lim, Changjin

doi:10.1007/s43188-019-00009-1

Cited by 5 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these chemicals, such as phthalates, have been linked to multiple chronic diseases, including reproductive disorders, diabetes, and thyroid function abnormality in epidemiological studies. Dibutyl phthalate has been recognized as a class 1B reproductive toxicant in the REACH authorization list, , and 1-methylnaphthalene has been reported as a neurotoxicant and lung carcinogen . Naphthalene and benzophenone classes are potential carcinogens due to radical formation after being transformed in humans …”

Section: Resultsmentioning

confidence: 99%

Disposable Polypropylene Face Masks: A Potential Source of Micro/Nanoparticles and Organic Contaminates in Humans

Guo

Liu

Xiang

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

We have been effectively protected by disposable propylene face masks during the COVID-19 pandemic; however, they may pose health risks due to the release of fine particles and chemicals. We measured micro/nanoparticles and organic chemicals in disposable medical masks, surgical masks, and (K)N95 respirators. In the breathing-simulation experiment, no notable differences were found in the total number of particles among mask types or between breathing intensities. However, when considering subranges, <2.5 μm particles accounted for ∼90% of the total number of micro/nanoparticles. GC-HRMS-based suspect screening tentatively revealed 79 (semi)volatile organic compounds in masks, with 18 being detected in ≥80% of samples and 44 in ≤20% of samples. Three synthetic phenolic antioxidants were quantified, and AO168 reached a median concentration of 2968 ng/g. By screening particles collected from bulk mask fabrics, we detected 18 chemicals, including four commonly detected in masks, suggesting chemical partition between the particles and the fabric fibers and chemical exposure via particle inhalation. These particles and chemicals are believed to originate from raw materials, intentionally and nonintentionally added substances in mask production, and their transformation products. This study highlights the need to study the long-term health risks associated with mask wearing and raises concerns over mask quality control.

show abstract

Section: Resultsmentioning

confidence: 99%

Disposable Polypropylene Face Masks: A Potential Source of Micro/Nanoparticles and Organic Contaminates in Humans

Guo

Liu

Xiang

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Similar activities of transaminases were noted after 4-week exposure to 2-methylnaphthalene (1-MN isomer) at a dose of 50 mg/m 3 and after 13 weeks (6 h daily, 5 days/week) exposure to 1-MN at a dose of 30 ppm (approx. 174 mg/m 3 ) in rats of both sexes [ 32 , 33 ]. Based on the results of histopathological examinations, it was found that 1-MN mainly affected the upper respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggested that the no observed adverse effect level (NOAEL) is 4 ppm (approx. 23 mg/m 3 ) [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolism and <i>in vitro</i> assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene

Świercz

Stępnik

Gromadzińska

et al. 2022

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: 1-Methylnaphthalene (1-MN) is composed of 2 benzene rings and belongs to polycyclic aromatic hydrocarbons. The metabolism of 1-MN in laboratory animals and bacteria leads to the formation of 1-naphthoic acid (1-NA). Material and Methods: In this study the distribution of 1-NA in lung, liver, spleen, kidney and urinary excretion of 1-NA in rats after single and repeated inhalation exposure to 1-MN vapors were investigated. The activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and cytochrome were measured of the rats. Genotoxic effects were evaluated with the in vitro micronucleus test on V79 hamster fibroblasts. Results: The concentrations of 1-NA in the tissues of rats after single and repeated exposure to 1-MN were dependent on the exposure dose. High levels of 1-NA were found in kidneys of animals after the single and repeated exposure to 1-MN. With an increase of 1-MN dose, an increase in the activity of cytochrome P450 (CYP1A1 and CYP1A2) was observed in the liver of rats. Compared to control animals, significantly higher ALT activity was noted in serum of rats exposed to 1-MN. The micronuclei frequency in V79 cells exposed to 1-MN (in the range of analyzable concentrations; i.e., 5-25 µg/ml) did not differ significantly from the vehicle control, whereas urine extracts from rats exposed to 1-MN induced a significant increase in the frequency of micronuclei compared to urine extracts from the group of control animals. Conclusions: Metabolism of 1-MN in rats after the inhalation exposure leading to 1-NA was mainly observed during the first day after the end of exposure. It is likely that 1-MN metabolites present in rat urine can induce the increased micronuclei frequency as was shown in V79 cells.

show abstract

“…Murata et al [23] reported no lung toxicity in mice in a 13-week repeated dose toxicity study. However, Kim et al [24] reported that in the rats exposed by inhalation to 1-MN, some toxic effects were observed in the upper respiratory system and the no-observed-adverse-effect level was suggested to be 4 ppm on the basis of histopathological findings. In addition, 1-MN showed lung carcinogenicity in the mice fed a diet containing 0.075% or 0.15% 1-MN [23].…”

Section: Animal Groups and The Collection Of Biological Materialsmentioning

confidence: 99%

The effects of 1-methylnaphthalene after inhalation exposure on the serum corticosterone levels in rats

Świercz

Stępnik

2020

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: This paper reports on the trend of the stressogenic stimulus caused by a repeated exposure to 1-methylnaphthalene (1-MN) vapors at the nominal concentrations of 0 mg/m 3 (the control restrainer), 50 mg/m 3 or 200 mg/m 3 in the nose-only inhalation system, by analyzing the serum corticosterone (CORT) levels in rats. Material and Methods: Three groups of rats were exposed in restrainers to 1-MN vapors at the nominal concentrations of 0 mg/m 3 , 50 mg/m 3 or 200 mg/m 3 for 5 days. One control group of animals spent all the time during the experiment in an individually ventilated plastic cage. The serum CORT concentrations were determined in all 4 groups of the rats. The blood samples drawn from the tail vein were collected every day after termination of the 6-h exposure. On the fifth day, blood samples were collected 15 min, 30 min, 45 min, 1 h, and 3 h after termination of the 6-h exposure. Results: On the fifth day of the study, no statistically significant changes in body weights between all groups of animals were found. After 5 days of the observation, increased food intake in the control groups was noted. Significantly higher CORT concentrations in the rats exposed to 1-MN at 200 mg/m 3 and in the animals from the control restrainer were found, comparing to the animals exposed to 1-MN at 50 mg/m 3 and the animals from the control cage. Conclusions: The application of 6-h restraining induced high concentrations of the stress hormone, CORT, in the blood of rats. The short-term exposure of rats to 1-MN non-linearly reduced the restraint stress measured with CORT concentration.

show abstract

Thirteen-week inhalation toxicity study of 1-methylnaphthalene in F344 rats

Cited by 5 publications

References 5 publications

Disposable Polypropylene Face Masks: A Potential Source of Micro/Nanoparticles and Organic Contaminates in Humans

Disposable Polypropylene Face Masks: A Potential Source of Micro/Nanoparticles and Organic Contaminates in Humans

Metabolism and <i>in vitro</i> assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene

The effects of 1-methylnaphthalene after inhalation exposure on the serum corticosterone levels in rats

Contact Info

Product

Resources

About