Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague–Dawley rats

MacKenzie, Susan A.; Lamb, Ian; Schmidt, Jean M.; Deege, Lora; Morrisey, Michael J.; Harper, Marc S.; Layton, Raymond J.; Prochaska, Lee M.; Sanders, C.; Locke, Mary; Mattsson, Joel L.; Fuentes, Angel; Delaney, Bryan

doi:10.1016/j.fct.2006.09.016

Cited by 81 publications

(34 citation statements)

References 19 publications

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“…Hammond et al found that overall health, body weight gain, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, and gross and microscopic appearance of tissues were comparable between rats fed Bt and conventional corn varieties for 90 days 26 . Furthermore, some research groups also reported similar results in their 90-day safety studies using rats 32,33,43 . In addition to these general toxicity tests, a special toxicity test has been published.…”

Section: Small Experiments Animalssupporting

confidence: 53%

Safety Evaluation of Bt Plants

Shimada

Murata

Miyazaki

2008

JARQ

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Bt plants are insect-resistant plants engineered to carry the gene coding the insecticidal protein of a soil bacterium, Bacillus thuringiensis. These transgenic plants provide a highly effective method of insect control and reduce dependence on pesticide chemicals. In consequence, they have provided higher yields, reduced crop mycotoxin levels because of the effective lowering of the insect damage, and have decreased the pesticide spraying work and cost. However, there are public concerns about the safety of Bt plants for humans, animals and the environment. This review describes recent research on the safety evaluation of Bt plants, focusing on our results in the toxicological studies of Bt11 corn.

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Section: Small Experiments Animalssupporting

confidence: 53%

Safety Evaluation of Bt Plants

Shimada

Murata

Miyazaki

2008

JARQ

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“…In the 90-day or 13-week feeding studies in rats, no statistical difference was uncovered in either the relative body and ovary weight of rats fed transgenic corns (Hammond et al, 2006;Healy et al, 2008), maize (MacKenzie et al, 2007;He et al, 2009;Appenzeller et al, 2009a and2009b), rice (Schroder et al, 2007) or soybeans (Appenzeller et al, 2008;Delaney et al, 2008b); and there were no histopathologic lesions in ovaries from rats fed DAS-59122-7 maize (Cry34Ab1 and Cry35Ab1 proteins; He et al, 2008). Furthermore, Malley et al (2007) reported higher mean uterus weight during the estrous stage of rats fed maize DAS-59122-7 (Cry34Ab1 and Cry35Ab1 proteins) or 5002B (commercial rodent diets) v. the 33R77 group (non-transgenic reference maize grain), 091 group (non-transgenic nearisogenic maize grain) or 5002A (commercial rodent diets); however, this might be due to the fact that the proportion of rats in proestrus and estrus in the 59122 and 5002B groups was greater than that in the 5002A, 091 and 33R77 maize grain groups, in which a greater proportion of rats were in metestrus and diestrus.…”

Section: Introductionmentioning

confidence: 94%

“…Long-term and multigenerational feeding studies Long-term feeding studies. In a 90-day or 13-weeks feeding studies on rats, several groups have reported that there were no effects on male reproductive organs such as testes, epididymides and prostate in rodents compared with rats receiving non-GM food in long-term study when the diet was treated with different GM foods (Hammond et al, 2006;MacKenzie et al, 2007;Schroder et al, 2007;Appenzeller et al, 2008Appenzeller et al, , 2009aAppenzeller et al, and 2009bDelaney et al, 2008b;Healy et al, 2008;He et al, 2008 and No apparent differences in percentages of testicular cell populations (haploid, diploid and tetraploid).…”

Section: Velimirov Et Al (2008)mentioning

confidence: 99%

Do genetically modified crops affect animal reproduction? A review of the ongoing debate

Zhang

Shi

2011

Animal

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In the past few years, genetically modified (GM) crops aimed at producing food/feed that became part of the regular agriculture in many areas of the world. However, we are uncertain whether GM food and feed can exert potential adverse effects on humans or animals. Of importance, the reproductive toxicology of GM crops has been studied using a number of methods, and by feeding GM crops to a number species of animals to ensure the safety assessment of GM food and feed. It appears that there are no adverse effects of GM crops on many species of animals in acute and short-term feeding studies, but serious debates of effects of long-term and multigenerational feeding studies remain. The aims of this review are to focus on the latest (last 3 to 4 years) findings and debates on reproduction of male and female animals after feeding daily diets containing the GM crops, and to present the possible mechanism(s) to explain their influences.

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“…Because people are worried about the potentially adverse effect of Bt rice and broiler chicken are extremely sensitive to changes in diet (MacKenzie et al 2007), it was evaluated whether diet comprised of transgenic Bt rice containing the Cry1Ab/1Ac had any adverse effects on broiler chickens when compared with diet containing the non-GM parental rice and to analyse residual of the Cry1Ab/1Ac gene in the chicken body.…”

Section: Introductionmentioning

confidence: 99%

Effects of a diet containing genetically modified rice expressing theCry1Ab/1Acprotein (Bacillus thuringiensistoxin) on broiler chickens

Gao

Zhang

et al. 2015

Archives of Animal Nutrition

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The aim of this study was to evaluate the effect of feeding Bacillus thuringiensis (Bt) rice expressing the Cry1Ab/1Ac protein on broiler chicken. The genetically modified (GM) Bt rice was compared with the corresponding non-GM rice regarding performance of feeding groups, their health status, relative organ weights, biochemical serum parameters and occurrence of Cry1Ab/1Ac gene fragments. One hundred and eighty day-old Arbor Acres female broilers with the same health condition were randomly allocated to the two treatments (6 replicate cages with 15 broilers in each cage per treatment). They received diets containing GM rice (GM group) or its parental non-GM rice (non-GM group) at 52-57% of the air-dried diet for 42 days. The results show that the transgenic rice had a similar nutrient composition as the non-GM rice and had no adverse effects on chicken growth, biochemical serum parameters and necropsy during the 42-day feeding period. In birds fed the GM rice, no transgenic gene fragments were detected in the samples of blood, liver, kidneys, spleen, jejunum, ileum, duodenum and muscle tissue. In conclusion, the results suggest that Bt rice expressing Cry1Ab/1Ac protein has no adverse effects on broiler chicken. Therefore, it can be considered as safe and used as feed source for broiler chicken.

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Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague–Dawley rats

Cited by 81 publications

References 19 publications

Safety Evaluation of Bt Plants

Safety Evaluation of Bt Plants

Do genetically modified crops affect animal reproduction? A review of the ongoing debate

Effects of a diet containing genetically modified rice expressing theCry1Ab/1Acprotein (Bacillus thuringiensistoxin) on broiler chickens

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