Thirteen-week dietary intake of rapeseed oil or soybean oil as the only dietary fat in Wistar Kyoto rats—change in blood pressure

Naito, Yukiko; Kasama, Kikuko; Yoshida, Hiromichi; Ohara, Naoki

doi:10.1016/s0278-6915(00)00076-4

Cited by 31 publications

(32 citation statements)

References 23 publications

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“…These results indicate that canola oil ingestion alone for 25 days affects antioxidant enzyme activity. Previous studies have shown that the in the canola oil feeding (with no added salt) reduced the activities of SOD and catalase in the hepatic cytosol of SHR and WKY rats [11,24]. The present study has also shown that in the presence of salt, both canola oil and soybean oil ingestion reduced the activity of GPx compared with the soybean oil group without salt.…”

Section: Discussionsupporting

confidence: 72%

“…Previous studies have reported an increase in plasma lipids due to canola oil ingestion [11,12,24]. In the present study, canola oil ingestion alone increased the concentration of total cholesterol and LDL-C compared with soybean oil alone.…”

Section: Discussionsupporting

confidence: 57%

“…HDL-C in both the canola oil and soybean oil groups with salt was higher compared with the non salt groups. Previous studies in SHR and WKY rats have shown increases in total cholesterol and HDL-C with administration of canola oil compared to soybean oil [11,12,24]. Research has found an association between oxidised LDL-C and the pathogenesis of atherosclerosis [29].…”

Section: Discussionmentioning

confidence: 99%

“…The association between salt intake and hypertension is well known [32], which is evident in the present the study. Evidence indicates that canola oil intake has an effect on blood pressure in the SHRSP rat and its related strains [3,24]. However, the blood pressure in the canola oil groups was not consistently different from soybean oil.…”

Section: Discussionmentioning

confidence: 99%

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The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

et al. 2011

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BackgroundThis study aimed to determine if 25 days of canola oil intake in the absence of excess dietary salt or together with salt loading affects antioxidant and oxidative stress markers in the circulation. A further aim was to determine the mRNA expression of NADPH oxidase subunits and superoxide dismutase (SOD) isoforms in the aorta of stroke-prone spontaneously hypertensive (SHRSP) rats.MethodsMale SHRSP rats, were fed a defatted control diet containing 10% wt/wt soybean oil or a defatted treatment diet containing 10% wt/wt canola oil, and given tap water or water containing 1% NaCl. Blood was collected at the end of study for analysis of red blood cell (RBC) antioxidant enzymes, RBC and plasma malondialdehyde (MDA), plasma 8-isoprostane and plasma lipids. The aorta was removed and the mRNA expression of NOX2, p22phox, CuZn-SOD, Mn-SOD and EC-SOD were determined.ResultsIn the absence of salt, canola oil reduced RBC SOD and glutathione peroxidase, and increased total cholesterol and LDL cholesterol compared with soybean oil. RBC glutathione peroxidase activity was significantly lower in both the salt loaded groups compared to the soybean oil only group. In addition, RBC MDA and plasma HDL cholesterol were significantly higher in both the salt loaded groups compared to the no salt groups. Plasma MDA concentration was higher and LDL cholesterol concentration lower in the canola oil group loaded with salt compared to the canola oil group without salt. The mRNA expression of NADPH oxidase subunits and SOD isoforms were significantly reduced in the canola oil group with salt compared to canola oil group without salt.ConclusionIn conclusion, these results indicate that canola oil reduces antioxidant status and increases plasma lipids, which are risk factors for cardiovascular disease. However, canola oil in combination with salt intake increased MDA, a marker of lipid peroxidation and decreased NAPDH oxidase subunits and aortic SOD gene expression.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

et al. 2011

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“…Hydrogenated soybean oil and hydrogenated canola oil shorten the survival of SHRSP similarly (Huang et al, 1997;Miyazaki et al, 1998). Decreased platelet counts (Naito et al, 2000a), increased erythrocyte fragility, severe renal injury involving lesions in blood vessels (Miyazaki et al, 2000) and elevated blood pressure (Naito et al, 2000b) are associated with dietary canola oil. Similar anti-nutritional activities of canola oil have been observed in rats of other strains (Naito et al, 2000b), mice (Kameyama et al, 1996) and pigs (Sauer et al, 1997;Innis and Dyer, 1999).…”

Section: Introductionmentioning

confidence: 99%

Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

et al. 2010

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-Canola and some other types of oil unusually shorten the survival of stroke-prone spontaneously hypertensive rats (SHRSP), compared with soybean oil, perilla oil and animal fats. Since differential effects of canola and soybean oil on steroid hormone metabolism were suggested by a preliminary DNA microarray analysis as a reason for this, the steroid hormone levels in the serum and tissues of SHR-SP fed different oils were investigated. The testosterone levels in the serum and the testes were found to be significantly lower in the canola oil group than in the soybean oil group, while no significant differences were detected in the corticosterone and estradiol levels in tissues. In a second experiment, it was found that hydrogenated soybean oil, with a survival-shortening activity comparable to that of canola oil, also decreased the testosterone level in testes to a similar degree. The testosterone-lowering activity of canola and hydrogenated soybean oil observed in SHRSP was considered in relation to other factors possibly affecting the physiology of SHRSP.

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Toxicity and Safety of Fats and Oils

Kitts

2005

Bailey's Industrial Oil and Fat Products

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The past two decades has produced an ever increasing awareness of the role of dietary fat in the etiology of different chronic diseases (e.g. diabetes, coronary heart disease and cancer). In addition, advances in food technology methods for preserving and processing food lipids for retained nutritional and sensory appeal has coincided with increased awareness concerning the safety of dietary fats and oil sources, as they relate to both the visible and non‐visible components of the total crude lipid fraction. Increased calorie consumed from fat sources not only provides consumer exposure to natural fat and oil components (e.g. fatty acids, sterols etc.), but also derived products of oxidation and hydrogenation and the presence of natural, environmental (pollutants) or intentional (e.g. additives) xenobiotics which co‐exist, or accumulate, in the crude lipid fraction. Thus, understanding the safety of dietary fats and oils requires not only an awareness of the elements of lipid chemistry of soluble constituents in the lipid phase, but also the associated reaction conditions that may convert them to toxic products. Moreover, by predicting a risk from the combined relative toxicity and the level of exposure to the organism will enable assessment of a hazard to exposure to these chemicals. In this chapter, a number of reactive and labile fat soluble constituents are assessed for safety and potential toxicity in regard to both initiating and propagating the cascade of events that may lead to a toxic end‐point measure. Endogenous (e.g. co‐oxidation reactions) as well as exposure to exogenous (e.g. photoxidation or presence of man made pollutants) xenobiotics are analyzed in respect to the potential for inducing adverse health effects.

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Thirteen-week dietary intake of rapeseed oil or soybean oil as the only dietary fat in Wistar Kyoto rats—change in blood pressure

Cited by 31 publications

References 23 publications

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

Toxicity and Safety of Fats and Oils

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