Third-line therapy for metastatic colorectal cancer

Gundgaard, Maria Gry; Soerensen, Jette Led; Ehrnrooth, Eva

doi:10.1007/s00280-007-0573-x

Cited by 11 publications

(7 citation statements)

References 61 publications

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“…For example, the objective response rate (ORR) for third-line treatment in lung cancer was only ~6–23% (6). The ORRs for the most common chemotherapy regimens used in third-line therapy for metastatic colorectal cancer vary from 5 to 36% (7).…”

Section: Intractable Cancermentioning

confidence: 99%

Basket Trials for Intractable Cancer

et al. 2019

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Currently, genomic characterization has become standard of care for tumor types such as non-small cell lung cancer, breast cancer, melanoma, and colorectal cancer. A deep understanding of genomic alterations in different tumor types would help identify potentially actionable genomic changes which occur across a wide variety of tumor types. A basket trial is a new type of clinical trial for which eligibility is based on the presence of a specific genomic alteration, irrespective of histology. Basket trials are phase II screening trials for the off-label use of a targeted drug in patients with the same genomic alterations for which it was approved. Intractable cancer refers to a type or condition of cancer which is unresponsive or resistant to treatment; intractable cancers may be classified into five subtypes as follows: hard-to-treat condition of common advanced cancer after multiple-line therapy, rare cancer in which no standard of care has been recommended, advanced cancer in which standard of care does not work well, cancer accompanied with organ dysfunction, and cancers in older or younger cancer patients. Previous studies have demonstrated that in basket trials, genomic-guided therapy yields clinical benefits in intractable cancer, thereby providing novel insights into the optimal clinical management of such cancers. In this review, we describe a novel way to classify intractable cancer, and summarize the current knowledge on such cancers. We additionally provide information on the role of basket trials in intractable cancer.

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Section: Intractable Cancermentioning

confidence: 99%

Basket Trials for Intractable Cancer

et al. 2019

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“…One could argue that it was the change in chemo regime rather than the surgical resection that helped the patient. In a recent review paper [ 10 ], Gundgaard et al reported median time to progression (mTTP) up to 7 months and a medium overall survival (mOS) of 16 months with third line chemotherapy. The highest mÔÔP, 9.8 months, was reported for the combination of cetuximab combined with irinotecan, the treatment our patient received.…”

Section: Discussionmentioning

confidence: 99%

Adrenalectomy for solitary adrenal metastasis from colorectal cancer: A case report

et al. 2008

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“…It is generally accepted that a solitary adrenal metastasis should be resected immediately to achieve good prognosis in some cancer types [14][15]. According to the histopathological diagnosis, chemoregimen might be changed [14].…”

Section: Discussionmentioning

confidence: 99%

“…In autopsy studies, the prevalence of incidentaloma is 1-9% [13] and the rate of metastasis ranges from 1.9-17.4% [1,9]. It is generally accepted that a solitary adrenal metastasis should be resected immediately to achieve good prognosis in some cancer types [14][15]. According to the histopathological diagnosis, chemoregimen might be changed [14].…”

Section: Discussionmentioning

confidence: 99%

Benign pheochromocytoma associated with colorectal cancer: Case report

Kaçan¹,

Kılıçkap²,

Babacan³

et al. 2013

CMJ

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Among all cancers, colorectal cancer is the second leading cause of cancer related death. Liver and lung are known as the main metastatic sites of colorectal cancer, on the other hand the metastasis of adrenal is clinically rare. Formerly, metastases were detected at autopsy, but due to improved imaging and diagnostic techniques, many of these lesions now can be detected on routine followup imaging. Patients with adrenal metastasis are considered having systemic spread and therefore unsuitable for surgical resection. That's why, isolated adrenal metastasis presents a therapeutic dilemma in colorectal cancer patients. In this case, we report an adrenal mass in a patient with colorectal cancer to whom rectosigmoidectomy, colectomy and adrenal metastasectomy were performed. The adrenal mass was benign. For solitary and resectable lesions adrenalectomy can be performed and prolonged survival can be achieved in selected patients. Also, this enables to achieve right histopathological diagnosis. Keywords: Colorectal cancer, adrenal mass, adrenalectomy ÖzetKolorektal kanser tüm kanserler arasında ölüme neden olan ikinci sıklıktaki kanserdir. Karaciğer ve akciğer kolorektal kanserlerin ana metastaz yerleri iken adrenal metastaz klinik olarak nadirdir. Eskiden metastazlar otopsilerde saptanırken, görüntüleme ve tanısal tekniklerin gelişmesi sayesinde rutin takiplerde fark edilebilir. Adrenal metastazı olan hastalar diffüz sistemik yayılım kabul edilir ve cerrahi rezeksiyona uygun değillerdir. Bu nedenle kolorektal kanserli hastalarda izole adrenal metastaz tedavide ikilem yaratmaktadır. Bu olguda hemikolektomi ve adrenal metastazektomi uygulanan kolorektal kanserli hastada adrenal kitleyi rapor etmekteyiz. Adrenal kitle iyi huylu idi. Rezeksiyona uygun klinik soliter lezyonlar seçili hastalarda yapılabilir ve uzun süreli sağkalım sağlar. Aynı zamanda doğru tanının konmasını sağlar. Anahtar sözcükler: Kolorektal kanser, adrenal kitle, adrenalektomiGeliş tarihi

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Third-line therapy for metastatic colorectal cancer

Abstract: Third-line therapy in advanced colorectal cancer may improve mOS for patients with MCRC. Therefore, randomized studies should be conducted in the future.

Cited by 11 publications

References 61 publications

Basket Trials for Intractable Cancer

Basket Trials for Intractable Cancer

Adrenalectomy for solitary adrenal metastasis from colorectal cancer: A case report

Benign pheochromocytoma associated with colorectal cancer: Case report

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