Third degree atrio-ventricular-block caused by malignant non-Hodgkin's lymphoma: an unusual indication for epicardial pacing

Aleksić, Ivan; Herse, B.; Busch, T.; Lotfi, S.; Sı̂rbu, Horia; Dalichau, H.

doi:10.1016/s0967-2109(98)00160-4

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…In the same study, patients with lymphoma dying with cardiac involvement revealed that 16% of patients with Hodgkin's disease, 25% with non-Hodgkin's lymphoma, and 33% of cases of mycosis fungoides had cardiac involvement [6]. There have been about 20 reported cases of patients with lymphomas infiltrating the heart presenting with AV block [7], complete heart block was described in a very few cases [6–8]. Sudden appearance of heart block in a patient with lymphoma and no underlying cardiac disease should lead to a suspicion of cardiac involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Sudden appearance of heart block in a patient with lymphoma and no underlying cardiac disease should lead to a suspicion of cardiac involvement. In general, malignant lymphoma which is initially presenting with cardiac symptoms is rarely diagnosed premortally, and has a poor prognosis [8]. …”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation range greatly depends upon the subtype of lymphoma and body organ involved and can vary from indolent to very aggressive type. Cardiac infiltration of lymphoma is well recognized and remains asymptomatic in majority of the cases but there are some reports of lymphoma involving the heart presenting with third degree heart block [6–8]. Lactic acidosis is very frequently seen in intensive care unit (ICU) as a cause of anion gap metabolic acidosis and is a significant marker of mortality.…”

Section: Introductionmentioning

confidence: 99%

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Complete Heart Block and Persistent Lactic Acidosis as an Initial Presentation of Non-Hodgkin Lymphoma in a Critically Ill Newly Diagnosed AIDS Patient

Ijaz

Tariq

Niazi

et al. 2014

Case Reports in Critical Care

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A 66-year-old male with newly diagnosed untreated acquired immunodeficiency syndrome (AIDS) presented with chronic nonspecific complaints of weakness, fatigue, myalgia, and weight loss. His initial EKG showed complete heart block necessitating temporary pacemaker placement. He had no previous history of cardiac disease. He was also found to have a persistent lactic acidosis and imaging studies showed abdominal lymphadenopathy. The patient underwent biopsy of these lymph nodes and was found to have diffuse large B-cell lymphoma. The hospital course was complicated by respiratory failure requiring mechanical ventilator support and cardiac arrest. Patient remained critically ill; he was not a candidate for chemotherapy and, after a month of hospitalization, he died. Lactic acidosis and heart block as an initial presentation of non-Hodgkin lymphoma in an AIDS patient are an unusual and unique presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complete Heart Block and Persistent Lactic Acidosis as an Initial Presentation of Non-Hodgkin Lymphoma in a Critically Ill Newly Diagnosed AIDS Patient

Ijaz

Tariq

Niazi

et al. 2014

Case Reports in Critical Care

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“…In addition to the risk of pulmonary tumor embolism during dual-chamber pacemaker insertion (13), manipulation of the transvenous lead by passing through the partially occluded SVC seemed challenging. Although epicardial pacemaker implantation has been reported as an alternative treatment for sick sinus syndrome or atrioventricular conduction disturbances caused by cardiac lymphoma (5,14), the procedure is highly invasive. Leadless pacemaker is a capsule-shaped device with a small battery possessing surface electrodes capable of endocardial sensing and pacing, and can be implanted non-surgically via the femoral vein.…”

Section: Leadless Pacemaker Implantationmentioning

confidence: 99%

Secondary Cardiac Lymphoma Presenting as Sick Sinus Syndrome and Atrial Fibrillation Which Required Leadless Pacemaker Implantation

et al. 2021

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Cardiac involvement of malignant lymphoma is relatively common, although such a phenomenon has subclinical manifestations that are difficult to detect. We herein describe a patient with atrial fibrillation and sick sinus syndrome as the main symptoms. Computed tomography showed a mass in the right atrium extending into the superior vena cava (SVC). We implanted the patient with a leadless pacemaker. Transvenous biopsy revealed a diffuse large B-cell lymphoma. The patient was treated successfully with chemotherapy including rituximab. This case suggested that cardiac lymphoma may cause sick sinus syndrome, and leadless pacemaker implantation is a safe treatment option in patients with partial SVC obstruction.

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Primary Breast Lymphoma With Sudden Death

Florez¹,

Gutiérrez²,

Haden-Pinneri³

et al. 2011

American Journal of Forensic Medicine &Amp; Pathology

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Primary breast lymphoma is a rare form of extranodal lymphoma. B cells constitute the most common type involving the breast. T cells represents only 3%. Even though lymphomas have a high predilection to metastasize to the heart, there are no specific clinical or radiological findings, and most of the cases are diagnosed at autopsy. We discuss the case of a 49-year-old woman with primary breast lymphoma who presented with sudden death. Autopsy revealed a primary T-cell lymphoma of the breast with tumoral infiltration of the atrioventricular node and transmural myocardial permeation with focal necrosis.

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Third degree atrio-ventricular-block caused by malignant non-Hodgkin's lymphoma: an unusual indication for epicardial pacing

Cited by 3 publications

References 10 publications

Complete Heart Block and Persistent Lactic Acidosis as an Initial Presentation of Non-Hodgkin Lymphoma in a Critically Ill Newly Diagnosed AIDS Patient

Complete Heart Block and Persistent Lactic Acidosis as an Initial Presentation of Non-Hodgkin Lymphoma in a Critically Ill Newly Diagnosed AIDS Patient

Secondary Cardiac Lymphoma Presenting as Sick Sinus Syndrome and Atrial Fibrillation Which Required Leadless Pacemaker Implantation

Primary Breast Lymphoma With Sudden Death

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