Third Case of Chronic Lymphocytic Leukaemia in a Carrier of the Inherited Ch1 Chromosome

Abstract

Termination of Pregnancy-Steptoe and Imran MEDICf=mNALThe mean duration of stay in hospital for patients undergoing abdominal hysterotomy was 101 days. The average stay after aspiration and laparoscopic sterilization was 2-4 days, the shortest being nine hours. In this latter group the mean age of the patients was 32-6-syears and the average number of children 3-5.Complications occurred in only seven cases of the series, and there were no maternal deaths. The details of these complications are as follows:Three cases of chronic nephritis and one case of mitral valve disease developed mild pyrexia, and were treated with penicillin.One case of incomplete aspiration of the uterus needed a repeat evacuation of retained products, blood transfusion, and antibiotics.One case required readmission because of a pelvic abscess; this was drained through a posterior colpotomy incision.One case had damage to vessels of the mesosalpinx which was not readily controlled, and laparotomy was immediately performed with suture of the damaged vessels.As a rule antibiotics were not prescribed without first taking swabs from the cervix and vagina for bacteriological examination, identification, and sensitivity. In the pyrexial cases the urine was also examined for possible infection as a routine. Blood grouping and haemoglobin estimations were also carried out in all cases. The amount of blood loss was always measured. Blood transfusion was used in only two patients in whom the preoperative haemoglobin level was below 73 %.The criteria for choosing to carry out the procedures on a day-patient basis were the absence of a complicating medical disease or signs of pelvic infection, the presence of a preoperative haemoglobin of 80%, and no occurrence of any complication during the operation. The procedure should be carried out only where full hospital facilities are available, and where preparation for a laparotomy has previously been made. The day cases received atropine 0 6 mg. only half an hour before operation. A short-acting general anaesthetic was always used, and full resuscitation facilities and equipment were available in a large recovery bay next to the theatre which could accommodate six patients. Intramuscular ergometrine 0 5 mg. was given half an hour before discharge to the patient's home. The patient's general practitioner was informed of the proposed plan of discharge from the hospital, and was also contacted during the morning of the operation on the day patients.In these circumstances it is believed that this combined procedure has a definite place in the gynaecological repertory, being safe, economic in usage of beds, and without disturbance of patients (Steptoe, 1969).

Genetic Heterogeneity in Familial Acute Myelogenous Leukemia: Evidence for a Second Locus at Chromosome 16q21-23.2

“…However, in a family with multiple siblings with chronic lymphocytic leukemia (CLL) (Schweitzer et al 1973) and a multigenerational AML family (Gunz et al 1978), HLA types differed among affected individuals. Three siblings developing CLL had a constitutional deletion of the short arm of chromosome 22 (Fitzgerald and Hamer 1969). Two brothers with childhood myelodysplasia with monosomy 7, a disorder that appears to be autosomal recessive (Horwitz 1997), had constitutional inversion of chromosome lp22q23 (Paul et al 1987).…”

Chromosome studies in a “cancer family”

“…Data from the literature4J' and from our own laboratory would suggest that PIC. 8. Karyotype of a cell coiltaining 45 chromosomes from the bone marrow culture from caw 1\31 carried out in 1968, after she had developed acute mycloblastic leakcmia.…”

Genetic susceptibility to chronic lymphocytic leukemia

“…The established relationship between HLA and Hodgkin's 51 Sibs M, M Sib M LK Videbaek 1958 52 Uncle, nephew Hudson et al 1960 53 Sibs M, M; Sibs M, M Gunz et al 1962 54 Sibs F, M, M Fitzgerald et al 55 Furbetta et al 1963 56 Grandparent M, parent F, offspring F Wisniewski 1966 57 Parent M, offspring M Rigby 1966 58 2 half-sibs Ardizzone et al 1968 59 Sibs M, M Magaraggia et al 1968 60 Sibs M, M McPhedran et al 1969 61 Sibs F, M, F, cousins F, M, M Fraumeni et al; 62 Blattner et al 1969 63 Sibs F, M, M Gunz et al 1969 64 Sibs M, F Sib CGL Sibs M, M Undritz et al 1971 65 Sibs M, M, M, F Potolosky et al 1971 66 Sibs F, F Sib LY, sib LY, sib acute LK Schweitzer et al 1973 67 Sibs F, M, M, F, F Blattner et al; 68 Neuland et al; 69 Shen et al; 70 Parent M, offspring M, M, F, F Caporaso et al 1991 71 Gunz 1975 72 3 first degree; 3 others Petzholdt 1976 73 Sibs M, M, M Fazekas et al 1978 74 Sibs, M, M, M Branda et al 1978 75 Parent F; offspring M Conley et al 1980 76 Sibs F, F Sibs M, M Nephew, maternal aunt; Nephew M; greataunt Alfinito et al 1982 77 Sibs F, F Vanni et al 1983 78 Sibs F, F Brok-Simoni et al 79 MZ twins F, F, sib F Hakim et al 1987 80 Eriksson et al 1987 81 Sibs M, M; Sibs M, F; Sibs M, F; MZ twins M; Parent M, offspring M; Parent M, offspring M Shah et al 1992 82 Sibs F, M, F Cuttner 1993 83 Sibs M, M; Sib M NHL Parent M, offspring M; MZ twins M, M Fernhout et al 1997 84 Sibs F, F, F, F Yuille et al 2000 9 Parent …”