Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activities

Abbas, Samir Y.; El‐Sharief, Marwa A. M. Sh.; Basyouni, Wahid M.; Fakhr, I. M. I.; El-Gammal, Eman W.

doi:10.1016/j.ejmech.2013.04.002

Cited by 76 publications

(35 citation statements)

References 11 publications

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“…The search for newer antibacterial and antifungal agents continues due to the rapid development the resistance among bacteria and fungi to the existing antimicrobial agents [17][18][19][20]. Even though novel broad spectrum antimicrobial agents were reported in recent years, the emergence of resistance has become an obstacle.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities

Moussa

El‐Sharief

Abbas

2016

European Journal of Medicinal Chemistry

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Section: A N U S C R I P Tmentioning

confidence: 99%

New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities

Moussa

El‐Sharief

Abbas

2016

European Journal of Medicinal Chemistry

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“…Compound 6 showed moderate activity against all the tested organisms. Surprising, incorporating 1H-benzo[d] [1,2,3]triazol-1-ylsulfonyl moiety in position 9 of visnagine as in structure 8 did not showed remarkable improvement on the antimicrobial activity. Compound 8 showed moderately activity against all the tested bacteria and no activity against all the tested fungi.…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

“…[1] A 1 mg/mL solution in dimethylformamide was used. The bacteria and fungi were maintained on nutrient agar and Czapek's-Dox agar media, respectively.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

“…[1][2][3] Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g] chromen-5-one) is one of the essential chemical constituents of the fruits and seeds of Ammi visnaga, family Umbelliferae and it is known to possess antispasmodic properties to the ureter and bile duct, treats angina, whooping cough, gall bladder and renal colic. [4] It is considered as a potent coronary vasodilator as well as its role in treating bronchial asthma.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Antimicrobial Activity of Furochromone, Benzofuran and Furocoumarin Derivatives Bearing Sulfonyl Moiety

Hessein¹,

El‐Sharief²,

Abbas³

et al. 2016

Croat. Chem. Acta

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New visnagin-9-sulfonamide derivatives 3 and 4a−c were synthesized through the reaction of visnagin-9-sulfonyl chloride 2 with amino compounds. Acetylation of compounds 4b and 4c gave the monoacetyl and diacetyl derivatives 5 and 6, respectively. Diazotization reaction of compound 4b afforded the corresponding benzotriazole derivative 8. Pyrazole and thiopyrimidine derivatives 9 and 10 were obtained via the opening of pyrone ring upon reaction of compound 3 with hydrazine hydrate and thiourea, respectively. In addition, hydrolysis of compound 3 with potassium hydroxide furnished the visnaginone derivative 11 which used as starting material for synthesize benzofuran derivatives 12−14 and bergaptene derivatives 15−17. The synthesized compounds were tested for antimicrobial activity. Furochromone derivatives 3, 4a−c, 5, 6 and 8 (visnagin-9-sulfonamide derivatives) demonstrate moderate antibacterial and antifungal activities compared with the antibacterial and antifungal activites of the standard drugs. Benzofuran derivatives 11−14 (visnaginone derivatives) showed the lowest antimicrobial activity among all the compounds investigated in this study. Furocoumarin derivatives 15a,b, 16 and 17 (furobenzopyransulfonamide [bergaptensulfonamides]) are moderately active against all the tested strains.

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“…So, the medical community faces a serious problem against infections caused by the pathogenic microbes and needs effective therapies and search for novel antimicrobial agents. The quest for new and effective antimicrobial agents, resistant to the mechanisms of defense of these bacteria, is of paramount importance [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new imidazolidineiminothione and bis-imidazolidineiminothione derivatives as potential antimicrobial agents

et al. 2017

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A series of new imidazolidineiminothiones (2-4) and bis-imidazolidineiminothiones (5) were synthesized through the cycloaddition reaction of N-arylcyanothioformamides (1) with some electrophilic reagents. Structure of imidazolidineiminothione derivatives were established based on spectroscopic IR, 1 H NMR, 13 C NMR, MS and elemental analyses data. These compounds were screened for their antibacterial and antifungal activities. Among the synthesized compounds, imidazolidineiminothione derivative 3a showed about 25% less potent effect than Ampicillin against S. epidermidis and B. subtilis (MIC, 0.49 μg/mL) and about 50 % less potent effect than Amphotericin B against A. clavatus and G. Candidum. Bisimidazolidineiminothione derivative 5a was equipotent to the Gentamycin in inhibiting the growth of N. gonorrhoeae (MIC, 0.49 μg/mL), and displayed 50% less active than Amphotericin B against A. clavatus.

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Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activities

Cited by 76 publications

References 11 publications

New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities

New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities

Synthesis and Antimicrobial Activity of Furochromone, Benzofuran and Furocoumarin Derivatives Bearing Sulfonyl Moiety

Synthesis and characterization of new imidazolidineiminothione and bis-imidazolidineiminothione derivatives as potential antimicrobial agents

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