Thiourea-Assisted Chiral Bicyclic Imidazole Organocatalysts: Design, Synthesis, and Application in Asymmetric Acylative Desymmetrization of Bisphenols for the Construction of P-Stereocenters

Palladium-Catalyzed Asymmetric Desymmetrization for the Simultaneous Construction of Chiral Phosphorus and Quaternary Carbon Stereocenters

“…Furthermore, this approach facilitates the simultaneous formation of multiple chiral centers in a single step, enhancing its versatility and efficiency. Over the past few decades, the asymmetric desymmetrization of dialkynyl-, diaryl-, and bisphenol-phosphine oxides, phosphoric esters, and phosphoryl dichlorides have been well explored to construct P-chiral phosphorus compounds. In 2009, Gouverneur and co-workers described a Mo-catalyzed desymmetrization ring-closing metathesis (RCM) reaction of divinylphosphine oxides to generate P-chiral phosphinates and phosphine oxides (Scheme b) .…”