Thioridazine plasma levels and clinical response

Gottschalk, Louis A.; Biener, R; Noble, Ernest P.; Birch, Herman; Wilbert, Donald E.; Heiser, Jon F.

doi:10.1016/s0010-440x(75)80002-2

Cited by 43 publications

(14 citation statements)

References 12 publications

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“…Drugs able to enter the CNS are obvious candidates as potential CNS antitumor agents. Psychotropic drugs in general (5)(6)(7)(8) and phenothiazine derivatives in particular (5-20) have been investigated for their antitumor properties. The possibility that phenothiazine derivatives may have had a favorable effect on human carcinomas has been discussed (19).…”

Section: Results Andmentioning

confidence: 99%

“…This study explored the relationship of the plasma concentration of thioridazine and its metabolites during chronic thioridazine administration (4 mg/kg PO) to the appearance of ECG abnormalities in schizophrenic patients. This investigation was one facet of ongoing studies on the pharmacokinetics of thioridazine (7) and mesoridazine (8) and clinical responses in acute schizophrenic patients. EXPERIMENTAL Subjects-The acute schizophrenic patients' selected were 21-55 years of age.…”

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confidence: 99%

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Plasma Concentrations of Thioridazine Metabolites and ECG Abnormalities

Gottschalk

Dinovo

Biener

et al. 1978

Journal of Pharmaceutical Sciences

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Section: Results Andmentioning

confidence: 99%

mentioning

confidence: 99%

Plasma Concentrations of Thioridazine Metabolites and ECG Abnormalities

Gottschalk

Dinovo

Biener

et al. 1978

Journal of Pharmaceutical Sciences

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“…Mean social alienation-personal disorganization scores from groups of acute and chronic schizophrenic patients who are not receiving psychoactive drugs remain quite elevated and stable (Gottschalk et al, 1970(Gottschalk et al, , 1975.…”

Section: Discussionmentioning

confidence: 99%

Profiles of children's psychological states derived from the Gottschalk-Gleser content analysis of speech

Gottschalk

Uliana

1979

J Youth Adolescence

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Comparison of 17 different scores, obtained with the Gottschalk-Gleser content analysis scales, with norms for White and Black children has now been made easily possible by the development of two types of profile forms. The scores derived by this method are transformed by plotting them, on a grid, to standard scores. Form 1 provides a nonlinear transformation that does correct for skewness of the score distribution. Form 2 provides a linear transformation that does not correct for skewness. These forms can be used to examine patterns and trends pictorially in psychological state or trait scores derived from speech by this method.

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“…Typescripts of these tape-recorded verbal samples were scored blindly on the Gottschalk Cognitive Impairment Scale, on which previous vali dation studies have been carried out [15,17,[19][20][21][22][23][24][25]. The verbal Gottschalk-Gleser Social Alienation-Per sonal Disorganization Scale measures the severity of the schizophrenic syndrome [15,[26][27][28][29][30][31][32], Within 1 week of the above testing, the subjects were administered a computerized EEG. The EEG data were scored blindly for major power spectra, abnormal frequencies, anterior versus posterior pa thology, and right versus left-sided pathological phe nomena.…”

Section: Methods and Proceduresmentioning

confidence: 99%

Comparative Neurobiological and Neuropsychological Deficits in Adolescent and Adult Schizophrenic and Nonschizophrenic Patients

Gottschalk¹,

Selin²

1991

Psychother Psychosom

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A group of 24 adolescents and young adults were classified according to four measures using Research Diagnostic Criteria on the dimension of the severity of their schizophrenic syndrome. Independent assessments by the Gottschalk-Gleser Social Alienation-Personal Disorganization Scale and the Abrams-Taylor Emotional Blunting Scale corroborated that the definite schizophrenic group (n = 7) was significantly more schizophrenic than the not schizophrenic group (n = 12), but not more so than the probably schizophrenic group (n = 5). The Halstead-Reitan Category Test and Rhythm Test significantly differentiated the definite schizophrenic group from the not schizophrenic group with respect to cognitive impairment. The Gottschalk-Gleser Cognitive Impairment Scale did not indicate a significant difference in cognitive function between these patient groups. The computerized EEG revealed a significantly higher percent of EEG abnormalities among the definite and probably schizophrenic groups than the not schizophrenic group of patients. These findings are analyzed and discussed.

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Thioridazine plasma levels and clinical response

Cited by 43 publications

References 12 publications

Plasma Concentrations of Thioridazine Metabolites and ECG Abnormalities

Plasma Concentrations of Thioridazine Metabolites and ECG Abnormalities

Profiles of children's psychological states derived from the Gottschalk-Gleser content analysis of speech

Comparative Neurobiological and Neuropsychological Deficits in Adolescent and Adult Schizophrenic and Nonschizophrenic Patients

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